Antibiotic
streptonigrin
Subclass of:
Picolinic Acids
Definitions related to streptonigrin:
  • An aminoquinone antineoplastic antibiotic isolated from the bacterium Streptomyces flocculus. Streptonigrin complexes with DNA and topoisomerase II, resulting in DNA cleavage and inhibition of DNA replication and RNA synthesis. This agent also acts as a reverse transcriptase inhibitor and causes free radical-mediated cellular damage. (NCI04)
    NCI
    U.S. National Cancer Institute, 2021
  • Complex cytotoxic antibiotic obtained from Streptomyces flocculus or S. rufochronmogenus. It is used in advanced carcinoma and causes leukopenia.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
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