Pharmacologic Substance
sulfadoxine
Effect:
Cellular Synthetic Activity Alteration
May Prevent:
Malaria
May Treat:
Malaria, Falciparum;
Pneumonia, Pneumocystis
Definitions related to sulfadoxine:
-
A broad-spectrum sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with bacteriostatic and antimalarial properties. Sulfadoxine competes with PABA for the bacterial enzyme dihydropteroate synthase, thereby preventing the incorporation of PABA into dihydrofolic acid, the immediate precursor of folic acid. This leads to an inhibition of parasitic folic acid synthesis and de novo synthesis of purines and pyrimidines, ultimately resulting in cell growth arrest and cell death.NCI ThesaurusU.S. National Cancer Institute, 2021
-
A long acting sulfonamide that is used, usually in combination with other drugs, for respiratory, urinary tract, and malarial infections.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
Return to OpenMD Medical Dictionary
> S
This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.