Pharmacologic Substance
sulfinpyrazone
[ suhl-fin-pir-uh-zohn ]
Effect:
Decreased Platelet Aggregation; Decreased Renal Organic Ion Excretion; Uricosuric Activity
May Prevent:
Thrombosis
May Treat:
Angina Pectoris;
Coronary Disease;
Gout;
Myocardial Infarction
Definitions related to sulfinpyrazone:
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A phenylbutazone derivative with uricosuric and antithrombotic properties. Sulfinpyrazone competitively inhibits reabsorption of urate at the proximal renal tubule in the kidney. This agent acts on the organic anion transport exchanger, thereby increasing uric acid excretion and decreasing serum uric acid levels resulting in the prevention of urate deposition. Sulfinpyrazone also blocks tubular excretion of various acidic drugs, resulting in increased serum concentration of the drugs. In addition, sulfinpyrazone and its active metabolite inhibit the synthesis of thromboxane A2, by competitively inhibiting the activity of cyclooxygenase, thereby preventing platelet aggregation through restoration of platelet survival time to normal, and decreasing platelet adhesiveness to subendothelial cells.NCI ThesaurusU.S. National Cancer Institute, 2021
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A uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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