Pharmacologic Substance
sulindac Audio
[ suh-lin-dak ]
Effect:
Decreased Prostaglandin Production
May Treat:
Arthritis, Gouty; Arthritis, Rheumatoid; Bursitis; Inflammation; Osteoarthritis; Shoulder Pain; Spondylitis, Ankylosing; Tendinopathy
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to sulindac:
  • A nonsteroidal anti-inflammatory drug (NSAID) that is being studied as a treatment for cancer.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • A sulfinylindene derivative prodrug whose sulfinyl moiety is converted in vivo to an active NSAID analgesic. Specifically, the prodrug is converted by liver enzymes to a sulfide which is excreted in the bile and then reabsorbed from the intestine. This helps to maintain constant blood levels with reduced gastrointestinal side effects.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • A sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cyclic guanosine monophosphate-phosphodiesterase (cGMP-PDE), an enzyme that inhibits the normal apoptosis signal pathway; this inhibition permits the apoptotic signal pathway to proceed unopposed, resulting in apoptotic cell death. (NCI04)
    NCI
    U.S. National Cancer Institute, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.