Pharmacologic Substance
sunitinib malate
[ soo-nih-tih-nib ma-layt ]
Effect:
Vascular Growth Decrease
May Treat:
Carcinoma, Renal Cell;
Gastrointestinal Stromal Tumors;
Neuroendocrine Tumors;
Pancreatic Neoplasms
More Information:
Definitions related to sunitinib malate:
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A drug used to treat gastrointestinal stromal tumors (GIST) that have not responded to treatment with imatinib mesylate (Gleevec). SU011248 is also used to treat advanced kidney cancer and is being studied in the treatment of other types of cancer. It is a type of tyrosine kinase inhibitor, a type of vascular endothelial growth factor (VEGF) receptor inhibitor, and a type of angiogenesis inhibitor.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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The orally bioavailable malate salt of an indolinone-based tyrosine kinase inhibitor with potential antineoplastic activity. Sunitinib blocks the tyrosine kinase activities of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor b (PDGFRb), and c-kit, thereby inhibiting angiogenesis and cell proliferation. This agent also inhibits the phosphorylation of Fms-related tyrosine kinase 3 (FLT3), another receptor tyrosine kinase expressed by some leukemic cells.NCI ThesaurusU.S. National Cancer Institute, 2021
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