Pharmacologic Substance
tapentadol
Brand Names:
Nucynta
Effect:
Analgesia; Decreased Organized Electrical Activity
May Treat:
Pain
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to tapentadol:
  • An opioid analgesic, MU OPIOID RECEPTOR agonist, and noradrenaline reuptake inhibitor that is used in the treatment of moderate to severe pain, and of pain associated with DIABETIC NEUROPATHIES.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • An orally available, synthetic benzenoid that acts as an agonist for the mu-opioid receptor (MOR) and inhibits the reuptake of noradrenaline, with potential anti-nociceptive activity. Upon oral administration, tapentadol binds to the MOR which enhances MOR-mediated signaling, interferes with the sensation of pain and results in an analgesic effect. Tapentadol also inhibits the reuptake of noradrenaline, which increases the levels of noradrenaline (NA), activates the inhibitory alpha-2 receptors and results in an analgesic effect.
    NCI
    U.S. National Cancer Institute, 2021
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