Quantitative Concept
therapeutic index
ther·a·peu·tic in·dex
Subclass of:
Treatment outcome
Definitions related to therapeutic index:
-
An indicator of the benefits and risks of treatment.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
-
The difference between the concentration at which clinical benefit is seen and that at which toxicity occurs. It is expressed as the range between the median effective dose and the median toxic dose.The larger the therapeutic index the safer a drug is.NCI ThesaurusU.S. National Cancer Institute, 2021
-
The ratio of the dose that produces toxicity (denominator) to the dose that produces a clinically desired or effective response (numerator). NOTE: The therapeutic index is a measure of a drug's safety, because a larger value indicates a wide margin between doses that are effective and doses that are toxic.CDISC TerminologyClinical Data Interchange Standards Consortium (CDISC), 2021
-
Therapeutic index, margin of safety that exists between the dose of a drug that produces the desired effect and the dose that produces unwanted and possibly dangerous side effects. This relationship is defined as the ratio LD50:ED50, where LD50 is the dose at which a drug kills 50 percent of a test...Encyclopedia Britannica, Inc., 2020
Return to OpenMD Medical Dictionary
> T
This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.