Hormone
thyrotropin alfa Audio
[ thahy-ruh-troh-pin, thahy-ro-truh- al-fuh ]
Brand Names:
Thyrogen
Effect:
Increased Thyroid Hormone Iodination; Increased Thyroid Stimulating Hormone Secretion
May Treat:
Thyroid Neoplasms
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to thyrotropin alfa:
  • A form of thyroid-stimulating hormone (TSH) that is made in the laboratory. It is used to test for remaining or recurring cancer cells in patients who have been treated for thyroid cancer.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • A highly purified recombinant glycoprotein form of human THYROID-STIMULATING HORMONE, produced by recombinant DNA technology comprising two non-covalently linked subunits, an alpha subunit of 92 amino acid residues containing two N-linked glycosylation sites, and a beta subunit of 118 residues containing one N-linked glycosylation site. The amino acid sequence of thyrotropin alfa is identical to that of human pituitary thyroid stimulating hormone.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • (recombinant thyrotropin alfa) A recombinant form of the human anterior pituitary glycoprotein thyroid stimulating hormone (TSH) with use in the diagnostic setting. With an amino acid sequence identical to that of human TSH, thyrotropin alfa binds to TSH receptors on normal thyroid epithelial cells or well-differentiated thyroid cancer cells, stimulating iodine uptake and organification, synthesis and secretion of thyroglobulin (Tg), triiodothyronine (T3), and thyroxine (T4).
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
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