Antibiotic
tigecycline
Brand Names:
Tygacil
Effect:
Decreased Mitosis; Decreased Protein Synthesis; Increased Cellular Death
May Treat:
Bacteremia;
Bacteroides Infections;
Clostridium Infections;
Escherichia coli Infections;
Haemophilus Infections;
Intraabdominal Infections;
Klebsiella Infections;
Legionellosis;
Pneumonia, Bacterial;
Skin Diseases, Bacterial;
Staphylococcal Infections;
Streptococcal Infections
More Information:
Definitions related to tigecycline:
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A broad-spectrum glycylcycline antibiotic derived from tetracycline. Tigecycline binds to the 30S ribosomal subunit, thereby interfering with the binding of aminoacyl-tRNA to the mRNA-ribosome complex. This prevents the incorporation of amino acid residues into the elongating peptide chain, inhibiting protein synthesis and eventually bacterial cell growth.NCI ThesaurusU.S. National Cancer Institute, 2021
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A tetracycline derivative that acts as a protein synthesis inhibitor. It is used as an antibacterial agent for the systemic treatment of complicated skin and intra-abdominal infections. It is also used for the treatment of community-acquired pneumonia.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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Tigecycline, a derivative of the tetracycline minocycline, is the first available glycylcycline antibiotic. Tigecycline inhibits protein synthesis by binding to the 30S ribosomal subunit. It is bacteriostatic.Merck & Co., Inc., 2020
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