Antibiotic
tigecycline
Brand Names:
Tygacil
Effect:
Decreased Mitosis; Decreased Protein Synthesis; Increased Cellular Death
May Treat:
Bacteremia; Bacteroides Infections; Clostridium Infections; Escherichia coli Infections; Haemophilus Infections; Intraabdominal Infections; Klebsiella Infections; Legionellosis; Pneumonia, Bacterial; Skin Diseases, Bacterial; Staphylococcal Infections; Streptococcal Infections
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to tigecycline:
  • A broad-spectrum glycylcycline antibiotic derived from tetracycline. Tigecycline binds to the 30S ribosomal subunit, thereby interfering with the binding of aminoacyl-tRNA to the mRNA-ribosome complex. This prevents the incorporation of amino acid residues into the elongating peptide chain, inhibiting protein synthesis and eventually bacterial cell growth.
    NCI
    U.S. National Cancer Institute, 2021
  • A tetracycline derivative that acts as a protein synthesis inhibitor. It is used as an antibacterial agent for the systemic treatment of complicated skin and intra-abdominal infections. It is also used for the treatment of community-acquired pneumonia.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • Tigecycline, a derivative of the tetracycline minocycline, is the first available glycylcycline antibiotic. Tigecycline inhibits protein synthesis by binding to the 30S ribosomal subunit. It is bacteriostatic.
    Merck Manuals
    Merck & Co., Inc., 2025
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