Pharmacologic Substance
tinzaparin
Effect:
Decreased Coagulation Factor Activity
May Treat:
Pulmonary Embolism;
Thromboembolism;
Venous Thrombosis
More Information:
Definitions related to tinzaparin:
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A drug that is used with another drug, warfarin, to treat blood clots that form deep in the veins and to prevent new blood clots from forming. It is a type of anticoagulant.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A low molecular weight heparin (LMWH), obtained by controlled enzymatic depolymerization of heparin from porcine intestinal mucosa, with antithrombotic properties. Tinzaparin is a potent inhibitor of several activated coagulation factors, especially Factors Xa and IIa (thrombin); its primary activity is mediated through the plasma protease inhibitor antithrombin. In addition, this agent may inhibit angiogenesis through: 1) competitive binding of the heparin-binding sites on endothelial cells for the proangiogenic cytokines vascular endothelial growth factor (VEGF) and beta-fibroblast growth factor (beta-FGF) and 2) increasing the release of tissue factor pathway inhibitor (TFPI), a negative regulator of angiogenesis.NCI ThesaurusU.S. National Cancer Institute, 2021
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A low-molecular-weight heparin with anticoagulant properties that is used in the prevention and treatment of VENOUS THROMBOEMBOLISM, and to prevent clotting during EXTRACORPOREAL CIRCULATION.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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