Pharmacologic Substance
tirapazamine Audio
[ teer-uh-pa-zuh-meen ]
Subclass of:
Triazines
Definitions related to tirapazamine:
  • A benzotriazine di-N-oxide with potential antineoplastic activity. Tirapazamine is selectively activated by multiple reductases to form free radicals in hypoxic cells, thereby inducing single-and double-strand breaks in DNA, base damage, and cell death. This agent also sensitizes hypoxic cells to ionizing radiation and inhibits the repair of radiation-induced DNA strand breaks via inhibition of topoisomerase II. (NCI04)
    NCI
    U.S. National Cancer Institute, 2021
  • A drug that makes tumor cells more sensitive to radiation therapy.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • A triazine derivative that introduces breaks into DNA strands in hypoxic cells, sensitizing tumor cells to the cytotoxic activity of other drugs and radiation.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • Antineoplastic, radiation sensitizing agent; 3-amino1,2,4-benzotriazine 1,4-dioxide.
    CRISP Thesaurus
    National Institutes of Health, 2006
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