Pharmacologic Substance
tirapazamine
[ teer-uh-pa-zuh-meen ]
Subclass of:
Triazines
Definitions related to tirapazamine:
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A benzotriazine di-N-oxide with potential antineoplastic activity. Tirapazamine is selectively activated by multiple reductases to form free radicals in hypoxic cells, thereby inducing single-and double-strand breaks in DNA, base damage, and cell death. This agent also sensitizes hypoxic cells to ionizing radiation and inhibits the repair of radiation-induced DNA strand breaks via inhibition of topoisomerase II. (NCI04)NCI ThesaurusU.S. National Cancer Institute, 2021
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A drug that makes tumor cells more sensitive to radiation therapy.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A triazine derivative that introduces breaks into DNA strands in hypoxic cells, sensitizing tumor cells to the cytotoxic activity of other drugs and radiation.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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Antineoplastic, radiation sensitizing agent; 3-amino1,2,4-benzotriazine 1,4-dioxide.CRISP ThesaurusNational Institutes of Health, 2006
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