Immunologic Factor
tositumomab Audio
[ tah-sih-too-moh-mab ]
Effect:
Increased B Lymphocyte Destruction
May Treat:
Lymphoma, Non-Hodgkin
Definitions related to tositumomab:
  • A monoclonal antibody that is used in the treatment of certain types of non-Hodgkin lymphoma. When tositumomab and iodine I 131 tositumomab (a form of tositumomab that has been chemically changed by adding radioactive iodine) are given together, the combination is called the Bexxar regimen.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • A murine IgG2 monoclonal antibody directed against the CD20 antigen, found on the surface of B-cells. Tositumomab binds to the CD20 surface membrane antigen, resulting in apoptosis, and may stimulate antitumoral cell-mediated and/or antibody-dependent cytotoxicity. (NCI04)
    NCI
    U.S. National Cancer Institute, 2021
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