Pharmacologic Substance
treosulfan Audio
[ tree-oh-sul-fan ]
Definitions related to treosulfan:
  • A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called alkylating agents.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • The prodrug of a bifunctional sulfonate alkylating agent with myeloablative, immunosuppressive, and antineoplastic activities. Under physiological conditions, treosulfan converts nonenzymatically to L-diepoxybutane via a monoepoxide intermediate. The monoepoxide intermediate and L-diepoxybutane alkylate DNA at guanine residues and produce DNA interstrand crosslinks, resulting in DNA fragmentation and apoptosis. In escalated doses, this agent also exhibits myeloablative and immunosuppressive activities.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
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