Pharmacologic Substance
triamterene
Brand Names:
Dyazide; Dyrenium; Maxzide
Effect:
Decreased Blood Pressure; Decreased Collecting Duct K+ Excretion; Decreased Distal Tubule K+ Excretion; Decreased Renal Ca++ Excretion; Increased Collecting Duct Na+ Excretion; Increased Distal Tubule Na+ Excretion; Increased Renal Mg++ Excretion
May Treat:
Edema; Hypertension; Hypokalemia
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to triamterene:
  • A pteridine derivative with potassium-sparing diuretic property. Triamterene blocks the sodium-potassium exchange pump (Na-K-ATPase) in the luminal membrane of principal cells in the late distal tubule, cortical collecting tubule and collecting duct in the kidney. This reversible inhibition of the electrogenic sodium transport decreases the lumen-negative transepithelial potential difference and thus reduces the driving force for K+ movement into the tubular lumen resulting in the inhibition of sodium reabsorption in exchange for K+ and H+.
    NCI
    U.S. National Cancer Institute, 2021
  • A pteridinetriamine compound that inhibits SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
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