Pharmacologic Substance
trifluridine
Brand Names:
Lonsurf; Viroptic
Effect:
Decreased DNA Replication; Decreased RNA Replication
May Treat:
Keratitis, Herpetic; Keratoconjunctivitis, Infectious
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to trifluridine:
  • A fluorinated thymidine analog with potential antineoplastic activity. Trifluridine is incorporated into DNA and inhibits thymidylate synthase, resulting in inhibition of DNA synthesis, inhibition of protein synthesis, and apoptosis. This agent also exhibits antiviral activity. (NCI04)
    NCI
    U.S. National Cancer Institute, 2021
  • An antiviral derivative of THYMIDINE used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis due to HERPES SIMPLEX virus. (From Martindale, The Extra Pharmacopoeia, 30th ed, p557)
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
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