Pharmacologic Substance
valdecoxib Audio
[ val-deh-kok-sib ]
Effect:
Decreased Prostaglandin Production
May Treat:
Arthritis, Rheumatoid; Dysmenorrhea; Osteoarthritis
Definitions related to valdecoxib:
  • A substance that is being studied as a treatment for pain and other side effects of cancer therapy. It belongs to the family of drugs called COX-2 inhibitors.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • A sulfonamide derivative and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic activities. Valdecoxib selectively binds to and inhibits cyclooxygenase (COX)-2, thereby preventing the conversion of arachidonic acid into prostaglandins, which are involved in the regulation of pain, inflammation, and fever. This NSAID does not inhibit COX-1 at therapeutic concentrations and therefore does not interfere with blood coagulation.
    NCI
    U.S. National Cancer Institute, 2021
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