Pharmacologic Substance
zibotentan
Definitions related to zibotentan:
  • A substance that is being studied in the treatment of prostate cancer. It belongs to the family of drugs called endothelin-receptor antagonists.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • An orally available selective antagonist of the endothelin-A (ET-A) receptor with potential antineoplastic activity. Zibotentan binds selectively to the ET-A receptor, thereby inhibiting endothelin-mediated mechanisms that promote tumor cell proliferation.
    NCI
    U.S. National Cancer Institute, 2021
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