Pharmacologic Substance
zonisamide
Brand Names:
Zonegran
Effect:
Neurotransmitter & Neuromuscular Transmitter Activity Alteration
May Treat:
Epilepsies, Partial
More Information:
Definitions related to zonisamide:
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A benzisoxazole and sulfonamide derivative that acts as a CALCIUM CHANNEL blocker. It is used primarily as an adjunctive antiepileptic agent for the treatment of PARTIAL SEIZURES, with or without secondary generalization.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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A sulfonamide derivative with an anticonvulsant property. The exact mechanism of action remains to be elucidated. Zonisamide appears to block sodium and calcium channels, thereby stabilizing neuronal membranes and suppressing neuronal hyper-synchronization. Although zonisamide shows affinity for the gamma-aminobutyric acid (GABA)/benzodiazepine receptor ionophore complex, it does not potentiate the synaptic activity of GABA. In addition, this agent also facilitates both dopaminergic and serotonergic neurotransmission.NCI ThesaurusU.S. National Cancer Institute, 2021
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