Pharmacologic Substance
tariquidar Audio
[ tar-ih-kwih-dar ]
Definitions related to tariquidar:
  • A substance that is being studied in the treatment of cancer. It may help tumor cells respond again to drugs they have become resistant (unable to respond) to. Tariquidar is a type of multidrug resistance inhibitor and a type of P-glycoprotein antagonist.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • An anthranilamide derivative with multidrug resistance properties. Tariquidar non-competitively binds to the p-glycoprotein transporter, thereby inhibiting transmembrane transport of anticancer drugs. Inhibition of transmembrane transport may result in increased intracellular concentrations of an anticancer drug, thereby augmenting its cytotoxicity. (NCI04)
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
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