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Molecules (Basel, Switzerland) Jul 2021A wide range of mediators are released from the pulp tissue because of bacterial invasion which causes inflammation. Interleukins (ILs) and matrix metalloproteinases...
A wide range of mediators are released from the pulp tissue because of bacterial invasion which causes inflammation. Interleukins (ILs) and matrix metalloproteinases (MMPs) have a leading role in initiating and spreading of inflammation because of their synergic action. Biomarkers such as ILs and MMPs can be identified via several methods, establishing the inflammatory response of the dental pulp. The aim of this systematic review is to evaluate the levels of ILs and/or MMPs in human dental pulp. PubMed, OVID, Cochrane, Scopus, Web of Science and Wiley online library databases were searched for original clinical studies. After applying inclusion and exclusion criteria, a quality assessment of studies was performed based on a modified Newcastle-Ottawa scale. In the review were included articles that evaluated the presence of ILs and/or MMPs in pulp tissue using enzyme-linked immunosorbent assay (ELISA) or western blot or multiplex assay. Six articles were included in the present synthesis. Although various diagnostic methods were used, statistically significant higher levels of ILs and/or MMPs were mostly found in the experimental groups compared to healthy pulp samples. The biomarkers studied can be a promising tool to evaluate pulp tissue health or even in pulpitis treatment.
Topics: Dental Pulp; Humans; Inflammation; Interleukins; Matrix Metalloproteinases
PubMed: 34299403
DOI: 10.3390/molecules26144129 -
Journal of Clinical and Experimental... Aug 2020This systematic review aimed to evaluate the efficiency and accuracy of digital impression techniques for implant-supported restorations, and to assess their economic... (Review)
Review
BACKGROUND
This systematic review aimed to evaluate the efficiency and accuracy of digital impression techniques for implant-supported restorations, and to assess their economic feasibility.
MATERIAL AND METHODS
Two independent electronic database searches were conducted in the Pubmed/MedLine, Cochrane Library, and Lilacs databases complimented by a manual search, selecting relevant clinical and studies published between 1st January 2009 and 28st February 2019. All type of studies ( and ) were included in this systematic review.
RESULTS
Twenty-seven studies (8 and 19 studies) fulfilled the inclusion criteria. No meta-analysis was performed due to a large heterogeneity of the study protocols. The passive fit of superstructures on dental implants presented similar results between digital and conventional impression techniques. The studies considered that several factors influence the accuracy of implant impression taking: distance and angulation between implants, depth of placement, type of scanner, scanning strategy, characteristics of scanbody, and operator experience. Regarding the economic viability of intraoral scanning systems, only one study reported any benefit in comparison with conventional techniques.
CONCLUSIONS
Digital impressions of dental implants can be considered a viable alternative in cases of one or two contiguous dental implants. However, more studies are needed to evaluate the accuracy of digital techniques in full-arch implant-supported restorations. Intraoral scanner, dental implant, prosthesis, misfit, systematic review.
PubMed: 32913577
DOI: 10.4317/jced.57025 -
Cranio : the Journal of... Jul 2023To evaluate whether there is a relationship between occlusion and body posture evaluated using a stabilometric platform.
OBJECTIVE
To evaluate whether there is a relationship between occlusion and body posture evaluated using a stabilometric platform.
METHODS
Observational studies that analyzed the relationship between dental occlusion (changes in mandibular position and/or dental malocclusion) and body posture evaluated with a stabilometric platform in patients older than 13 years without orthodontic or orthopedic intervention and systemically healthy were considered eligible for inclusion. PubMed, EMBASE, Science Direct, LILACS, and Google Scholar databases were searched to obtain articles published from September 2019 up to March 2020.
RESULTS
Twelve articles met the inclusion criteria, of which 66.7% showed a relationship between dental occlusion and body posture, and 33.3% found no relationship. The marked heterogeneity between studies did not allow data to be combined for meta-analyses.
CONCLUSION
For the mandibular positions, the postural changes were mainly in the mediolateral direction, while in the malocclusions, they were in the anteroposterior direction.
Topics: Humans; Malocclusion; Posture; Mandible; Observational Studies as Topic
PubMed: 33357146
DOI: 10.1080/08869634.2020.1857614 -
Journal of Dental Research, Dental... 2022Temporomandibular disorders have common signs and symptoms, including pain in the masticatory muscles, limitation or deviation in a mandibular range of motion, and... (Review)
Review
Temporomandibular disorders have common signs and symptoms, including pain in the masticatory muscles, limitation or deviation in a mandibular range of motion, and other common patient complaints, such as headache and earache. The main focus of this study was to collect comprehensive and integrated data on the effect of the posterior stop on temporomandibular joint disorders, as well as prevention, treatment, and follow-up care for the patients. The authors conducted the search in PubMed, SCOPUS, Web of Science, Cochrane Library, CINHAL, Medline, ProQuest, Google Scholar, Magiran, IranDoc, SID, and Iranmedex databases for relevant articles. A list of selected study sources, related conferences, and grey literature were manually searched in addition to the databases mentioned above. A 21-year time limit was imposed (2000-2021). Finally, 16 articles were selected to be reviewed in this systematic review. The designs of the included studies were heterogeneous, and due to the low number of studies covered, the authors could not carry out a meta-analysis. The causes of temporomandibular disorders are multifactorial and complex. Therefore, it is difficult to investigate the relationship between this disorder and predictors. The results of the present study indicate that to determine the effect of the posterior stop on temporomandibular joint disorders, more clinical trials and case-control studies should be conducted.
PubMed: 36704181
DOI: 10.34172/joddd.2022.025 -
European Archives of Paediatric... Aug 2023This study aims to evaluate whether there is a correlation between otitis and dental malocclusions.
PURPOSE
This study aims to evaluate whether there is a correlation between otitis and dental malocclusions.
METHODS
Electronic databases were searched for observational studies published until July 2021 without language or time restrictions.
PROSPERO
CRD42021270760. Observational studies on children with and without OM and/or malocclusion were included. After removing duplicates and excluding not-eligible articles, two reviewers screened relevant articles independently. Two reviewers independently extracted data and assessed data quality and validity through the Newcastle-Ottawa Scale (NOS) quality assessment tool for non-randomized studies.
RESULTS
Five studies met the selection inclusion criteria and were included in the studies for a total of 499 patients. Three studies investigated the relationship between malocclusion and otitis media, while the remaining two studies analyzed the inverse relationship and one of them considered eustachian tube dysfunction as a proxy of OM. An association between malocclusion and otitis media and vice versa emerged, although with relevant limitations.
CONCLUSION
There is some evidence that there is an association between otitis and malocclusion; however, it is not yet possible to establish a definitive correlation.
Topics: Humans; Child; Otitis Media; Malocclusion
PubMed: 37338742
DOI: 10.1007/s40368-023-00807-0 -
Community Dental Health Aug 2021To determine the association between malocclusion and the severity of dental caries among children and adolescents in the permanent dentition. (Meta-Analysis)
Meta-Analysis
OBJECTIVE
To determine the association between malocclusion and the severity of dental caries among children and adolescents in the permanent dentition.
METHOD
A search was conducted in Medline, Cochrane databases, Google scholar, Scopus and Web of Science through October 2020 for studies of malocclusion and dental caries among children and adolescents using the Dental Aesthetic Index (DAI) and the Decayed, Missing, Filled Teeth (DMFT) index. Quality was evaluated using the Newcastle-Ottawa tool for cross-sectional studies. Data were extracted using the Cochrane Collaboration guidelines. Meta-analysis used the Cochrane Program Review Manager Version 5. A random effects model was used to assess the association among different categories of malocclusion with dental caries. GRADE analysis assessed the certainty of evidence.
RESULTS
Five studies met the inclusion criteria. Handicapping malocclusion was significantly associated with higher mean DMFT scores (Mean difference: 1.03, 95% CI, 0.61, 1.44). Participants with severe malocclusion had higher mean DMFT when compared to subjects with normal occlusion (0.32, 95% CI, 0.13, 0.51). Definite malocclusion was also associated with higher mean DMFT scores (Mean difference: 0.19, 95% CI, 0.03, -0.35).
CONCLUSION
Malocclusion is associated with dental caries in the permanent dentition. DMFT scores and the strength of the association increased with severity of malocclusion. Low to moderate certainty of evidence was observed for association between handicapping, severe, and definite malocclusion with dental caries.
Topics: Adolescent; Child; Cross-Sectional Studies; DMF Index; Dental Care; Dental Caries; Dentition, Permanent; Humans; Malocclusion
PubMed: 33780175
DOI: 10.1922/CDH_00340Singh06 -
Journal of Clinical Medicine Jun 2020Animal studies and the scarce clinical trials available that have been conducted suggest that bioactive surfaces on dental implants could improve the osseointegration of... (Review)
Review
Animal studies and the scarce clinical trials available that have been conducted suggest that bioactive surfaces on dental implants could improve the osseointegration of such implants. The purpose of this systematic review was to compare the effectiveness of osseointegration of titanium (Ti) dental implants using bioactive surfaces with that of Ti implants using conventional surfaces such as sandblasted large-grit acid-etched (SLA) or similar surfaces. Applying the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement, the MEDLINE, PubMed Central and Web of Science databases were searched for scientific articles in April 2020. The keywords used were "dental implants", "bioactive surfaces", "biofunctionalized surfaces", and "osseointegration", according to the question: "Do bioactive dental implant surfaces have greater osseointegration capacity compared with conventional implant surfaces?" Risk of bias was assessed using the Cochrane Collaboration tool. 128 studies were identified, of which only 30 met the inclusion criteria: 3 clinical trials and 27 animal studies. The average STROBE (STrengthening the Reporting of OBservational studies in Epidemiology) and ARRIVE (Animal Research: Reporting of In Vivo Experiments) scores were 15.13 ± 2.08 and 17.7±1.4, respectively. Implant stability quotient (ISQ) was reported in 3 studies; removal torque test (RTT)-in 1 study; intraoral periapical X-ray and microcomputed tomography radiological evaluation (RE)-in 4 studies; shear force (SF)-in 1 study; bone-to-implant contact (BIC)-in 12 studies; and BIC and bone area (BA) jointly-in 5 studies. All animal studies reported better bone-to-implant contact surface for bioactive surfaces as compared to control implants with a statistical significance of < 0.05. Regarding the bioactive surfaces investigated, the best results were yielded by the one where mechanical and chemical treatment methods of the Ti surfaces were combined. Hydroxyapatite (HA) and calcium-phosphate (Ca-Ph) were the most frequently used bioactive surfaces. According to the results of this systematic review, certain bioactive surfaces have a positive effect on osseointegration, although certain coating biomolecules seem to influence early peri-implant bone formation. Further and more in-depth research in this field is required to reduce the time needed for osseointegration of dental implants.
PubMed: 32610687
DOI: 10.3390/jcm9072047 -
The European Journal of Prosthodontics... Jun 2023The aim of this systematic review was to explore the dental literature to identify high quality clinical studies that introduced methods of determining the vertical...
PURPOSE
The aim of this systematic review was to explore the dental literature to identify high quality clinical studies that introduced methods of determining the vertical dimension of occlusion (VDO), and additionally to find studies which assessed alterations in the VDO.
MATERIALS AND METHODS
An electronic search of the literature was conducted through PubMed , Embase, and Cochrane Library databases referring to the determination and alteration of the VDO by 12/2021.
RESULTS
A total of 215 records were obtained from the initial search. After the first two screenings, 33 studies were selected for inclusion. Correlations in the morphometric group ranged between r=0.18-0.87, p⟨0.05-0.001, correlations in the cephalometric group ranged between r=0.28-0.92, p⟨0.05-0.001, and correlations in the mechanometric group ranged between r=0.21- 0.75, p⟨0.05-0.01. Regarding the alteration of VDO, in all studies the increase ranged between 1.8-8 mm and the patients adapted .
CONCLUSIONS
No clear guidelines can be established yet, in relation to the determination and alteration of the VDO. There is no apparent benefit in using more invasive and complex methods compared to the use of the facial anatomical landmarks. Patient adaptation seems to be successful when the range of VDO increase was 1.8-6.0 mm.
PubMed: 37265247
DOI: 10.1922/EJPRD_2487Pissiotis13 -
Maedica Dec 2019The association between chronic periodontitis and cardiovascular disease is still controversial, despite the plethora of research on this topic. The objective of this...
The association between chronic periodontitis and cardiovascular disease is still controversial, despite the plethora of research on this topic. The objective of this systematic review is to update the level of evidence on connection between periodontal and cardiovascular disease. The review question is: could a link between periodontal disease and ischemic cardiac disease be established? A PubMed, Science Direct and Scopus systematic search was performed, which was restricted only to articles published in English or French during the last five years. This study followed PRISMA statement guidelines. A significant relationship between the periodontal and cardiovascular pathology in 17 selected studies was observed, although there was a huge methodological heterogeneity and no randomized study was found. It can be concluded that there is a connection between periodontal and cardiovascular disease, but the link mechanism is still not strongly proved. The scientific evidence level of the future research must be improved.
PubMed: 32153670
DOI: 10.26574/maedica.2019.14.4.384 -
Journal of Clinical Medicine Aug 2022The present review aimed to assess the possible relationship between occlusal overload and peri-implant bone loss. In accordance with the PRISMA guidelines, the MEDLINE,... (Review)
Review
The present review aimed to assess the possible relationship between occlusal overload and peri-implant bone loss. In accordance with the PRISMA guidelines, the MEDLINE, Scopus, and Cochrane databases were searched from January 1985 up to and including December 2021. The search strategy applied was: (dental OR oral) AND implants AND (overload OR excessive load OR occlusal wear) AND (bone loss OR peri-implantitis OR failure). Clinical studies that reported quantitative analysis of occlusal loads through digital contacts and/or occlusal wear were included. The studies were screened for eligibility by two independent reviewers. The quality of the included studies was assessed using the Risk of Bias in Non-randomized Studies of Interventions (ROBINS-I) tool. In total, 492 studies were identified in the search during the initial screening. Of those, 84 were subjected to full-text evaluation, and 7 fulfilled the inclusion criteria (4 cohort studies, 2 cross-sectional, and 1 case-control). Only one study used a digital device to assess excessive occlusal forces. Four out of seven studies reported a positive correlation between the overload and the crestal bone loss. All of the included studies had moderate to serious overall risk of bias, according to the ROBINS-I tool. In conclusion, the reported data relating the occlusal analysis to the peri-implant bone level seem to reveal an association, which must be further investigated using new digital tools that can help to standardize the methodology.
PubMed: 36013048
DOI: 10.3390/jcm11164812