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The Science of the Total Environment Dec 2017Numerous studies have explored the associations between environmental pollutants and pediatric health. Recent studies have investigated the issue in Asia, but no... (Review)
Review
Numerous studies have explored the associations between environmental pollutants and pediatric health. Recent studies have investigated the issue in Asia, but no systematic review has been published to date. This study aims to elucidate the issue by summarizing relevant epidemiologic evidence for cohorts in Asia, using information from the Birth Cohort Consortium of Asia (BiCCA). Environmental pollutants include mercury, environmental tobacco smoke (ETS), polychlorinated biphenyls (PCB), perfluoroalkyl substances (PFAS) and phthalates. This study sought to classify the effects of such compounds on fetal growth and pregnancy outcomes, neurodevelopment and behavioral problems, allergic disease and immune function and the endocrine system and puberty. These evidences showed ETS has been associated with infant birth weight, children's neurodevelopment and allergy disease; mercury and PCB have been shown to affect children's neurodevelopment; phthalate has effects on endocrine function; PFAS alters children's neurodevelopment, the endocrine system, and the allergic response. However, more consistent and coordinated research is necessary to understand the whole picture of single environmental and/or co-exposure and children's health. Therefore, harmonization and international collaboration are also needed in Asia.
Topics: Asia; Child; Child Health; Cohort Studies; Environmental Health; Environmental Pollutants; Female; Fetal Development; Humans; Mercury; Phthalic Acids; Polychlorinated Biphenyls; Pregnancy; Prenatal Exposure Delayed Effects; Tobacco Smoke Pollution
PubMed: 28755589
DOI: 10.1016/j.scitotenv.2017.07.081 -
Environmental Science and Pollution... Aug 2022Congenital heart defects (CHDs) are one of the major causes of death in infants and young children, and heavy metal exposure during pregnancy is one of the possible risk... (Meta-Analysis)
Meta-Analysis Review
Congenital heart defects (CHDs) are one of the major causes of death in infants and young children, and heavy metal exposure during pregnancy is one of the possible risk factors. However, the effect of heavy metal exposure on CHDs is still controversial. We searched English (PubMed, Web of Science) and Chinese (CNKI and WanFang database) databases for relevant articles. The summarized effect sizes and 95% confidence intervals (CIs) were calculated by pooling estimates using the random-effects model. Egger's test was used to estimate publication bias. Heterogeneity among studies was indicated by p-values and I. Finally, we conducted subgroup analyses to elucidate the causes of heterogeneity. Thirteen studies were included in this meta-analysis. A positive association between maternal exposure to heavy metals and CHDs was found. Pooling odds ratios (ORs) for arsenic, cadmium, mercury, and lead were 2.12, 1.30, 1.22, and 2.30, respectively for total CHDs. Regarding CHD subtypes, arsenic was associated with an increased risk of septal defects (OR: 1.82), barium with left ventricular outflow tract obstruction (LVOTO) (OR: 1.15) and septal defects (OR: 1.21), and lead with conotruncal defects (OR: 2.34) and LVOTO (OR: 1.93). A heterogeneous relationship was found between studies using different methods of measurement, which were mainly due to differences in actual exposure levels to heavy metals. This meta-analysis suggests significant associations between arsenic, cadmium, mercury, and lead exposure during pregnancy and an increased risk of specific CHDs in offspring. These findings underscore the importance of heavy metal exposure during pregnancy in the risk of CHDs in offspring.
Topics: Arsenic; Cadmium; Child; Child, Preschool; Female; Heart Defects, Congenital; Humans; Maternal Exposure; Mercury; Pregnancy; Risk Factors
PubMed: 35668266
DOI: 10.1007/s11356-022-21071-7 -
Environmental Health : a Global Access... Nov 2023Early life exposure to lead, mercury, polychlorinated biphenyls (PCBs), polybromide diphenyl ethers (PBDEs), organophosphate pesticides (OPPs), and phthalates have been... (Meta-Analysis)
Meta-Analysis
BACKGROUND
Early life exposure to lead, mercury, polychlorinated biphenyls (PCBs), polybromide diphenyl ethers (PBDEs), organophosphate pesticides (OPPs), and phthalates have been associated with lowered IQ in children. In some studies, these neurotoxicants impact males and females differently. We aimed to examine the sex-specific effects of exposure to developmental neurotoxicants on intelligence (IQ) in a systematic review and meta-analysis.
METHOD
We screened abstracts published in PsychINFO and PubMed before December 31st, 2021, for empirical studies of six neurotoxicants (lead, mercury, PCBs, PBDEs, OPPs, and phthalates) that (1) used an individualized biomarker; (2) measured exposure during the prenatal period or before age six; and (3) provided effect estimates on general, nonverbal, and/or verbal IQ by sex. We assessed each study for risk of bias and evaluated the certainty of the evidence using Navigation Guide. We performed separate random effect meta-analyses by sex and timing of exposure with subgroup analyses by neurotoxicant.
RESULTS
Fifty-one studies were included in the systematic review and 20 in the meta-analysis. Prenatal exposure to developmental neurotoxicants was associated with decreased general and nonverbal IQ in males, especially for lead. No significant effects were found for verbal IQ, or postnatal lead exposure and general IQ. Due to the limited number of studies, we were unable to analyze postnatal effects of any of the other neurotoxicants.
CONCLUSION
During fetal development, males may be more vulnerable than females to general and nonverbal intellectual deficits from neurotoxic exposures, especially from lead. More research is needed to examine the nuanced sex-specific effects found for postnatal exposure to toxic chemicals.
Topics: Child; Pregnancy; Humans; Male; Female; Polychlorinated Biphenyls; Lead; Sex Characteristics; Halogenated Diphenyl Ethers; Mercury; Insecticides; Organophosphorus Compounds; Prenatal Exposure Delayed Effects
PubMed: 37978510
DOI: 10.1186/s12940-023-01029-z -
Critical Reviews in Toxicology Nov 2017Elemental mercury (Hg) is a well-recognized neurotoxicant, but it is uncertain whether and for how long its neurotoxicity persists. Among studies that evaluated... (Review)
Review
Elemental mercury (Hg) is a well-recognized neurotoxicant, but it is uncertain whether and for how long its neurotoxicity persists. Among studies that evaluated previously-exposed workers, only one examined workers during and also years after exposure had ceased. The objective of this review is to create a series of 'synthetic' longitudinal studies to address the question of persistence of Hg neurotoxicity in occupationally exposed workers. We systematically reviewed studies describing objective motor and sensory effects in previously-exposed mercury workers. Data from physical examination (PE), neurobehavioral (NB) tests, and electrophysiological studies (EPS) were extracted into structured tables and examined for their consistency and dose-relatedness and then compared with the corresponding results from studies of currently exposed workers. We identified six cohorts that described neurological findings in 1299 workers, examined an average of 4.8-30 years after the cessation of exposure. Historical group mean U levels ranged from 23 to >500 μg/L, with U levels >6000 μg/L in some individuals. Overall, few findings were significant; most were inconsistent across the previous-exposure studies, and in comparisons between studies of previously and currently exposed workers. The results of this systematic review indicate that Hg-related neurotoxic effects detectable on PE, NB testing, and EPS are substantially reversed over time. To the extent that such effects do persist, they are reported principally in workers who have had very high-dose exposures. In addition, based on the limited available data, those effects reported to persist have been described as having little or no functional significance.
Topics: Adult; Air Pollutants, Occupational; Humans; Mercury; Middle Aged; Neuropsychological Tests; Neurotoxicity Syndromes; Occupational Diseases; Occupational Exposure
PubMed: 28722535
DOI: 10.1080/10408444.2017.1342599 -
Environmental Research May 2024Metalloestrogens are metals and metalloid elements with estrogenic activity found everywhere. Their impact on human health is becoming more apparent as human activities... (Meta-Analysis)
Meta-Analysis Review
BACKGROUND
Metalloestrogens are metals and metalloid elements with estrogenic activity found everywhere. Their impact on human health is becoming more apparent as human activities increase.
OBJECTIVE
Our aim is to conduct a comprehensive systematic review and meta-analysis of observational studies exploring the correlation between metalloestrogens (specifically As, Sb, Cr, Cd, Cu, Se, Hg) and Gestational Diabetes Mellitus (GDM).
METHODS
PubMed, Web of Science, and Embase were searched to examine the link between metalloestrogens (As, Sb, Cr, Cd, Cu, Se, and Hg) and GDM until December 2023. Risk estimates were derived using random effects models. Subgroup analyses were conducted based on study countries, exposure sample, exposure assessment method, and detection methods. Sensitivity analyses and adjustments for publication bias were carried out to assess the strength of the findings.
RESULTS
Out of the 389 articles identified initially, 350 met our criteria and 33 were included in the meta-analysis, involving 141,175 subjects (9450 cases, 131,725 controls). Arsenic, antimony, and copper exposure exhibited a potential increase in GDM risk to some extent (As: OR = 1.28, 95 % CI [1.08, 1.52]; Sb: OR = 1.73, 95 % CI [1.13, 2.65]; Cu: OR = 1.29, 95 % CI [1.02, 1.63]), although there is a high degree of heterogeneity (As: Q = 52.93, p < 0.05, I = 64.1 %; Sb: Q = 31.40, p < 0.05, I = 80.9 %; Cu: Q = 21.14, p < 0.05, I = 71.6 %). Conversely, selenium, cadmium, chromium, and mercury exposure did not exhibit any association with the risk of GDM in our study.
DISCUSSION
Our research indicates that the existence of harmful metalloestrogens in the surroundings has a notable effect on the likelihood of GDM. Hence, we stress the significance of environmental elements in the development of GDM and the pressing need for relevant policies and measures.
Topics: Pregnancy; Female; Humans; Diabetes, Gestational; Cadmium; Copper; Arsenic; Mercury; Observational Studies as Topic
PubMed: 38307186
DOI: 10.1016/j.envres.2024.118321 -
Exposure to Mercury in the Air and Its Effect on Cardiovascular Diseases (CVD): A Systematic Review.Iranian Journal of Public Health May 2024We aimed to verify the exposure to mercury in the air and its effect on cardiovascular disorders. (Review)
Review
BACKGROUND
We aimed to verify the exposure to mercury in the air and its effect on cardiovascular disorders.
METHODS
The review was conducted using PubMed, Scopus, Web of Science, Embase, and national databases (such as SID) from 1995-2022.
RESULTS
Mercury exposure can cause many disorders in humans, including neurodevelopmental disorders in fetuses and children, adverse cardiovascular outcomes, hypertension, and diabetes. Mercury is a human neurotoxin, and in recent years its potentially harmful effects on cardiovascular disease (CVD) have raised concerns, mainly due to mercury's role in reducing oxidative stress.
CONCLUSION
Possible mechanisms of mercury toxicity in CVD include mercury-selenium interaction, increased lipid peroxidation, and oxidative stress. In this article, we review studies that have investigated the relationship between mercury and CVD.
PubMed: 38912156
DOI: 10.18502/ijph.v53i5.15583 -
International Journal of Environmental... Feb 2022Gold is one of the most valuable materials but is frequently extracted under circumstances that are hazardous to artisanal and small-scale gold miners' health. A common... (Review)
Review
Gold is one of the most valuable materials but is frequently extracted under circumstances that are hazardous to artisanal and small-scale gold miners' health. A common gold extraction method uses liquid mercury, leading to a high exposure in workers. Therefore, a systematic review according to the PRISMA criteria was conducted in order to examine the health effects of occupational mercury exposure. Researching the databases PubMed, EMBASE and Web of Science yielded in a total of 10,589 results, which were screened by two independent reviewers. We included 19 studies in this review. According to the quantitative assessment, occupational mercury exposure may cause a great variety of signs and symptoms, in particular in the field of neuro-psychological disorders, such as ataxia, tremor or memory problems. However, many reported symptoms were largely unspecific, such as hair loss or pain. Most of the included studies had a low methodological quality with an overall high risk of bias rating. The results demonstrate that occupational mercury exposure seriously affects miners' health and well-being.
Topics: Gold; Humans; Mercury; Miners; Mining; Occupational Exposure
PubMed: 35206270
DOI: 10.3390/ijerph19042081 -
Antioxidants (Basel, Switzerland) Jul 2023Altered levels of heavy metals and essential elements have been associated with oxidative stress (OS) and metabolic and hormonal changes in women with polycystic ovary... (Review)
Review
Altered levels of heavy metals and essential elements have been associated with oxidative stress (OS) and metabolic and hormonal changes in women with polycystic ovary syndrome (PCOS). We aimed to summarize the knowledge on the association of heavy metals and essential elements with OS in PCOS. An electronic literature search using PubMed for studies published between January 2008 and April 2023 was conducted. We evaluated heavy metals and essential elements in relation to OS in PCOS in 15 articles. PCOS women had increased antimonium (Sb), cadmium (Cd), lead (Pb), mercury (Hg), arsenic (As), tellurium (Te), thallium (Tl) and osmium (Os) blood levels and decreased zinc (Zn) blood levels; the results of copper (Cu) blood levels were conflicting. Some studies showed a significant correlation between heavy metals (Sb, Cd, Pb, Hg, As, Te and Tl) and essential elements (Se, Zn, Cr, Ca, Mg and Cu) and markers of OS and chronic inflammation. Heavy metals (Sb, Cd, Pb and Hg) and essential elements (Zn, Cr, Se, Ca, Mg and Cu) were associated with metabolic and hormonal characteristics in PCOS. There might be a possible benefit from supplementation therapy in reducing OS and endocrinological problems related to PCOS. Our review confirmed an association between heavy metals and essential elements with OS in PCOS women. This systematic review is registered in PROSPERO under number CRD42023418453.
PubMed: 37507937
DOI: 10.3390/antiox12071398 -
Medicina (Kaunas, Lithuania) May 2021HIV has been a serious global health concern since its discovery, with about 37.9 million people living with HIV worldwide as of 2018. Sub-Saharan Africa (SSA) accounts... (Review)
Review
HIV has been a serious global health concern since its discovery, with about 37.9 million people living with HIV worldwide as of 2018. Sub-Saharan Africa (SSA) accounts for 68% of the infection and contributed 74% of the 1.5 million deaths in 2013 despite having only 12% of the total world population residing in the region. This systematic review has attempted to determine the association between heavy metal toxicity and the occurrence of non-communicable diseases in the HIV/AIDS population. Three databases were systematically searched: PubMed, Scopus, and Google Scholar for studies written in English and published between 1 April 2000 and 12 April 2020. Studies were excluded if the main outcomes were not measured or did not meet the inclusion criteria. All the six included studies are cross-sectional in design, and therefore were evaluated using the STROBE checklist. The data extraction was done using an extraction table; the ratio of female to male participants included in the study was 1.09:1. Qualitative analysis was used due to the heterogeneity in the heavy metal biomarkers and the outcome measured by the included studies. Two studies compared the concentration of heavy metals in HIV-positive and HIV-negative participants while one compared the levels between HAART-naïve and HAART-treated participants, and three determined the association between heavy metal toxicity and non-communicable diseases (liver fibrosis, anaemia, and reproductive parameters, respectively) in HIV-positive patients. Blood lead, cadmium, and mercury levels were higher in HIV-seropositive than -seronegative subjects, whereas serum zinc level was lower in HIV-seropositive than -seronegative subjects, but the causal association between heavy metals and non-communicable diseases in HIV subjects is largely unknown. Interdisciplinary research between nutrition, toxicology, and human health is envisaged for primary and secondary prevention and treatment.
Topics: Africa South of the Sahara; Cross-Sectional Studies; Female; HIV Infections; Humans; Male; Metals, Heavy; Noncommunicable Diseases
PubMed: 34068196
DOI: 10.3390/medicina57050492