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Nihon Shokakibyo Gakkai Zasshi = the... 2022A woman in her 30s was diagnosed with ulcerative colitis (UC) 4 years ago and treated with tacrolimus, azathioprine, and prednisolone 5mg (PSL). Skin ulcers appeared on...
A woman in her 30s was diagnosed with ulcerative colitis (UC) 4 years ago and treated with tacrolimus, azathioprine, and prednisolone 5mg (PSL). Skin ulcers appeared on the right lower leg during the course of treatment, diagnosed as pyoderma gangrenosum (PG). The patient initially improved with an increased PSL and infliximab dose, but then developed multiple skin ulcers and folliculitis throughout her body. She was transferred to our hospital for PG exacerbation treatment. She developed fever after transfer and contrast-enhanced computed tomography showed multiple abscesses in the lungs and kidneys. PSL was decreased and infliximab was discontinued. Antibiotic therapy and granulocyte/monocyte apheresis (GMA) were started. Fever persisted even after antibiotic treatment, and her general condition did not improve. A right renal abscess puncture was performed. Pus was sterile. A sterile abscess associated with PG was suspected. The PSL dose was increased to 1mg/kg and infliximab restarted. Thereafter, the patient's general condition improved, and both lung and renal abscesses contracted. Skin ulcer epithelialization was also observed. Abdominal symptoms were mild during the course of the disease, and colonoscopy showed only a localized ulcerative lesion in the rectum. The patient was later transferred to the department of dermatology at our hospital for PG treatment. Aseptic abscesses are caused by neutrophil infiltration without infection and have been reported to be associated with neutrophilic dermatosis and inflammatory bowel disease. UC-associated aseptic abscess is rare. This is only the sixth case in Japan. Aseptic abscesses can occur in various sites, including subcutaneous and deep organs, but this is the first kidney abscess case. In previous reports, PSL, infliximab, colchicine, and infliximab+GMA were used for aseptic abscesses associated with UC. They all showed abscess reduction. Aseptic abscesses associated with PG should be considered if abscess lesions occur during the course of UC, and a treatment strategy including enhanced immunosuppression should be considered.
Topics: Humans; Female; Colitis, Ulcerative; Pyoderma Gangrenosum; Abscess; Infliximab; Azathioprine; Prednisolone
PubMed: 36351620
DOI: 10.11405/nisshoshi.119.1014 -
Arab Journal of Gastroenterology : the... Aug 2023This is a retrospective study to evaluate the safety and efficacy of endoscopic ultrasound-guided pelvic abscess drainage (EUS-PAD) in a single hospital setting.
BACKGROUND AND STUDY AIM
This is a retrospective study to evaluate the safety and efficacy of endoscopic ultrasound-guided pelvic abscess drainage (EUS-PAD) in a single hospital setting.
PATIENTS AND METHODS
The referral criteria for EUS-PAD included patients with a pelvic abscess (PA) that was amenable for the procedure. A total of 14 patients with PA treated with EUS-PAD were included in this study. The mean patient age was 57.4 years, and male-to-female ratio was 7:7. Overall, there were six cases of appendiceal perforation, five of rectal cancer and one case each of the diverticular perforation, perianal abscess, and walled-off necrosis.
RESULTS
Overall, 100% of procedures were successful. Clinical success was achieved in 11 patients and they were discharged after EUS-PAD within 21.4 days on an average and the average duration of stent placement before removal was 27.0 days. Of all, six patients achieved complete improvement status where the cause was appendiceal perforation while two and one of the patients were recovered where the causes were post-curative operation for carcinoma and walled-off necrosis, respectively. Eight out of eleven patients who exhibited appendiceal perforation or underwent radical rectal cancer surgery were discharged after an average of 9.4 days post EUS-PAD. Although two patients showed temporary improvement, with perianal abscess and controlled rectal carcinoma, the PA worsened as the primary disease intensified. The PA drainage was ineffective in three patients where two of them had uncontrolled rectal cancer and one had diverticular perforation.
CONCLUSION
Conclusively, the EUS-PAD is not only a reliable, safe, and efficient alternative to surgical and percutaneous drainage but also a valuable procedure with a high success rate for patients with acute infections, such as those who have had an appendiceal perforation or curative surgery. Poor indications and contraindications for EUS-PAD include uncontrolled gastrointestinal perforation and direct tumor invasion.
Topics: Humans; Male; Female; Middle Aged; Abscess; Retrospective Studies; Abdominal Abscess; Drainage; Endosonography; Rectal Neoplasms; Stents; Ultrasonography, Interventional; Necrosis; Carcinoma; Treatment Outcome
PubMed: 37689578
DOI: 10.1016/j.ajg.2023.07.003 -
German Medical Science : GMS E-journal 2022Pyometra is a rare gynecological condition and is characterized by pus accumulation in the uterine cavity. It occurs more frequently in postmenopausal women than...
BACKGROUND
Pyometra is a rare gynecological condition and is characterized by pus accumulation in the uterine cavity. It occurs more frequently in postmenopausal women than tubo-ovarian abscesses, which constitute a more common gynecological complication among premenopausal women.
OBJECTIVE
A 72-year-old woman was admitted to our emergency department with lower abdominal pain, diarrhea and fever for the last three days. The laboratory results were indicative to sepsis. The clinical examination revealed sensitivity by palpation of the lower abdomen without any signs of acute abdomen. The gynecological assessment showed pus outflow through the cervix and a pus culture was done. The ultrasound examination found an enlarged uterus, full of hypoechoic fluid, unclear borders between endometrium-myometrium, a mixed echogenicity adnexal mass and no free fluid in the pouch of Douglas. A computed tomography (CT) of the abdomen showed the presence of pyometra and a tubo-ovarian abscess of the right adnexa.
METHOD
The patient was treated with intravenous antibiotic therapy. When the patient was hemodynamically stable and afebrile, she underwent ultrasound-guided dilatation and curettage of the cervical canal and the endometrium in order to exclude an underlying malignancy, under general anesthesia.
RESULTS
The patient responded promptly to the intravenous antibiotic therapy which was adapted to the pus culture result. The laboratory results withdrew to normal values and the patient was discharged after fifteen days of hospitalization in an afebrile and hemodynamically stable condition.
CONCLUSION
Pyometra and tubo-ovarian abscess in postmenopausal women could be a lethal complication of pelvic inflammatory disease. The key in treatment is the dilatation of the cervix and drainage of the pyometra. The administration of intravenous antibiotics and drainage through the cervix could be a suitable method of treatment for pyometra in older patients or those with poor performance status if only the histological examination is negative for malignancy.
Topics: Abdominal Abscess; Abscess; Aged; Anti-Bacterial Agents; Female; Humans; Oophoritis; Postmenopause; Pyometra; Salpingitis
PubMed: 35875245
DOI: 10.3205/000311 -
Emergency Radiology Jun 2015Computed tomography (CT) is an effective, readily available diagnostic imaging tool for evaluation of the emergency room (ER) patients with the clinical suspicion of... (Review)
Review
Computed tomography (CT) is an effective, readily available diagnostic imaging tool for evaluation of the emergency room (ER) patients with the clinical suspicion of perianal abscess and/or infected fistulous tract (anorectal sepsis). These patients usually present with perineal pain, fever, and leukocytosis. The diagnosis can be easy if the fistulous tract or abscess is visible on inspection of the perianal skin. If the tract or abscess is deep, then the clinical diagnosis can be difficult. Also, the presence of complex tracts or supralevator extension of the infection cannot be judged by external examination alone. Magnetic resonance imaging (MRI) is the best imaging test to accurately detect fistulous tracts, especially when they are complex (Omally et al. in AJR 199:W43-W53, 2012). However, in the acute setting in the ER, this imaging modality is not always immediately available. Endorectal ultrasound has also been used to identify perianal abscesses, but this modality requires hands-on expertise and can have difficulty localizing the offending fistulous tract. It may also require the use of a rectal probe, which the patient may not be able to tolerate. Contrast-enhanced CT is a very useful tool to diagnose anorectal sepsis; however, this has not received much attention in the recent literature (Yousem et al. in Radiology 167(2):331-334, 1988) aside from a paper describing CT imaging following fistulography (Liang et al. in Clin Imaging 37(6):1069-1076, 2013). An infected fistula is indicated by a fluid-/air-filled soft tissue tract surrounded by inflammation. A well-defined round to oval-shaped fluid/air collection is indicative of an abscess. The purpose of this article is to demonstrate the usefulness of contrast-enhanced CT in the diagnosis of acute anorectal sepsis in the ER setting. We will discuss the CT appearance of infected fistulous tracts and abscesses and how CT imaging can guide the ER physician in the clinical management of these patients.
Topics: Abscess; Acute Disease; Contrast Media; Diagnosis, Differential; Emergency Service, Hospital; Humans; Rectal Fistula; Tomography, X-Ray Computed
PubMed: 25421387
DOI: 10.1007/s10140-014-1284-3 -
Journal of Pediatric Urology Apr 2016Pediatric renal abscesses are an uncommon diagnosis, with a paucity of data comparing treatment modalities. Patient presentation ranges from persistent dull...
INTRODUCTION
Pediatric renal abscesses are an uncommon diagnosis, with a paucity of data comparing treatment modalities. Patient presentation ranges from persistent dull flank/abdominal pain with or without fevers, to those who are overtly ill, presenting with hemodynamic instability and bacteremia. Management for pediatric renal abscesses is typically based on results extrapolated from small series in adult cohorts, with conservative measures recommended when the lesion is <3 cm.
OBJECTIVE
This study evaluated the presentation, management and outcomes of a contemporary cohort of pediatric patients with renal abscesses.
STUDY DESIGN
A total of 16 consecutive pediatric patients with radiologically diagnosed intra-renal or peri-nephric abscesses from 1990 to 2012 were identified. Patients were identified by querying institutional records via ICD-9 and CPT codes referencing renal abscess. Charts were retrospectively reviewed to evaluate multiple clinical variables, including: presenting symptoms, size of abscess, management strategy and clinical outcomes. Clinical resolution was confirmed via repeat ultrasound or computed tomography.
RESULTS
The median age at presentation was 13 years (range 1 month-18 years) and 13/16 patients (81%) were female. Abscess formation was secondary to: urinary tract infection in 13 (81%); hematogenous seeding from a skin infection in one (6%); and an unknown etiology in two (12%) patients. The most common organism identified on urine culture was Escherichia coli (10, 77%). Hematogenous seeding was confirmed in only one case, with Staphylococcus aureus growing on culture from both a cutaneous lesion and percutaneous drainage of the renal lesion. Overall, abscesses were a median of 2.2 cm (IQR 2, 3.7), with 13 (81%) successfully managed with conservative therapy, including intravenous antibiotics, with resolution on repeat imaging at a median of 21 days (range 6-55). For patients presenting with abscesses ≤3 cm, conservative measures were employed in 10/11 cases, with 100% success rate. Three patients had larger abscesses (3.8, 4, and 10 cm), which resolved after treatment with percutaneous drainage. A voiding cystourethrogram was performed in 10 patients, with two (20%) detecting an abnormality (low-grade vesicoureteral reflux, which required no further intervention).
CONCLUSIONS
Pediatric renal abscesses were most commonly small and secondary to an E. coli UTI. Most small (≤3 cm) renal abscesses resolved with conservative management. Percutaneous drainage should be considered for lesions >3 cm and in patients who remain persistently febrile, despite culture-specific antibiotics, are immunocompromised or critically ill.
Topics: Abscess; Adolescent; Anti-Bacterial Agents; Child; Child, Preschool; Diagnosis, Differential; Drainage; Female; Follow-Up Studies; Humans; Infant; Infant, Newborn; Kidney Diseases; Male; Retrospective Studies; Tomography, X-Ray Computed
PubMed: 26522771
DOI: 10.1016/j.jpurol.2015.05.037 -
World Journal of Surgery Feb 2017This article provides a current overview on clinical anatomy, pathophysiology, workup and surgical management of anorectal abscesses. Based on the three-dimensional... (Review)
Review
This article provides a current overview on clinical anatomy, pathophysiology, workup and surgical management of anorectal abscesses. Based on the three-dimensional nature of anorectal abscesses, a novel treatment-based classification is proposed. It examines the basis of a philosophic shift from simple drainage to concomitant definitive treatment of abscesses and their underlying primary fistulous trajectories. Complications are discussed specifically in this context.
Topics: Abscess; Anus Diseases; Drainage; Humans; Rectal Fistula; Symptom Assessment
PubMed: 27766401
DOI: 10.1007/s00268-016-3767-8 -
International Journal of Pediatric... Aug 2017The aim of this study was to analyse the epidemiology, clinical presentation, diagnostic clues, as biochemical parameters and imaging studies, of children with acute...
OBJECTIVES
The aim of this study was to analyse the epidemiology, clinical presentation, diagnostic clues, as biochemical parameters and imaging studies, of children with acute neck infections (ANI) to identify possible independent prognostic factors leading to complications and prolonged hospitalization.
METHODS
Records of children admitted to a tertiary university hospital from January 2008 to December 2014 with a diagnosis of ANIs were reviewed retrospectively. Diseases were categorized according to the site of infection and patients were divided into two groups: children (aged<10 years) and adolescents (aged 10-18 years).
RESULTS
A total of 102 patients belonged to the children's group and 57 were adolescents. Forty-nine patients (27.2%) received antibiotics prior to presentation. The most frequent ANI was peritonsillar abscess (n = 72). Four peritonsillar abscesses progressed to parapharyngeal and retropharyngeal abscesses (n = 2 respectively). An association between age and type of abscess was found, with most of the retropharyngeal abscesses occurring in children (p = 0.05), and the submandibular abscesses in adolescents (p < 0.001). The most frequent symptoms/signs were fever (63.9%) and odynophagia (50.6%). Upon admission, all patients received intravenous antibiotics and 86.8% underwent drainage of the abscess. Cultures were harvested in 87 abscesses and the most frequent pathogen isolated was Streptococcus pyogenes. Signs of airway obstruction occurred in two patients with submandibular abscess, one with peritonsillar and one with parapharyngeal abscess. There were no cases of death or severe sequelae. Recurrent ANIs were observed in eight patients including two infected branchial cysts. Children, presence of multiple abscesses and palpable cervical mass on admission, absence of odynophagia and pharyngeal bulging, surgery with general anaesthesia and surgery after 24 h, were associated with prolonged hospitalization. Presence of toothache and neck pain on admission were identified as predictors of complications.
CONCLUSIONS
The present study found, that often, the diagnosis and treatment of neck abscesses in paediatric patients is not straightforward, but can achieve a favourable outcome. The primary location of the ANI appears to vary in different paediatric age groups. Younger age, presence of multiple abscesses or a palpable cervical mass on admission, were associated with prolonged hospitalization. Presence of toothache and neck pain on admission was identified as possible predictors of complications.
Topics: Abscess; Acute Disease; Adolescent; Anti-Bacterial Agents; Child; Child, Preschool; Drainage; Female; Hospitalization; Humans; Infant; Infections; Male; Neck; Retrospective Studies
PubMed: 28688554
DOI: 10.1016/j.ijporl.2017.05.020 -
The Journal of Surgical Research Jan 2021Literature on pediatric breast abscesses is sparse; therefore, treatment is based on adult literature which has shifted from incision and drainage (I&D) to needle... (Comparative Study)
Comparative Study
BACKGROUND
Literature on pediatric breast abscesses is sparse; therefore, treatment is based on adult literature which has shifted from incision and drainage (I&D) to needle aspiration. However, children may require different treatment due to different risk factors and the presence of a developing breast bud. We sought to characterize pediatric breast abscesses and compare outcomes.
MATERIALS AND METHODS
A retrospective review of patients presenting with a primary breast abscess from January 2008 to December 2018 was conducted. Primary outcome was persistent disease. Antibiotic utilization, treatment required, and risk factors for abscess and recurrence were also assessed. A follow-up survey regarding scarring, deformity, and further procedures was administered. Fisher's exact and Kruskal-Wallis tests for group comparisons and multivariable regression to determine associations with recurrence were performed.
RESULTS
Ninety-six patients were included. The median age was 12.8 y [IQR 4.9, 14.3], 81% were women, and 51% were African-American. Most commonly, patients were treated with antibiotics alone (47%), followed by I&D (27%), and aspiration (26%). Twelve patients (13%) had persistent disease. There was no difference in demographic or clinical characteristics between those with persistent disease and those who responded to initial treatment. The success rates of primary treatment were 80% with antibiotics alone, 90% with aspiration, and 96% with I&D (P = 0.35). The median time to follow-up survey was 6.5 y [IQR 4.4, 8.5]. Four patients who underwent I&D initially reported significant scarring.
CONCLUSIONS
Treatment modality was not associated with persistent disease. A trial of antibiotics alone may be considered to minimize the risk of breast bud damage and adverse cosmetic outcomes with invasive intervention.
Topics: Abscess; Adolescent; Anti-Bacterial Agents; Breast Diseases; Child; Drainage; Female; Follow-Up Studies; Humans; Male; Paracentesis; Recurrence; Retrospective Studies; Risk Factors; Staphylococcal Infections; Staphylococcus; Treatment Outcome
PubMed: 32858320
DOI: 10.1016/j.jss.2020.07.014 -
Revista Espanola de Enfermedades... Jan 2023A 70-year-old male with a large abscessed GIST is reported. Symptoms, laboratory results, diagnostic imaging and surgical field information are provided. It is a rare...
A 70-year-old male with a large abscessed GIST is reported. Symptoms, laboratory results, diagnostic imaging and surgical field information are provided. It is a rare initial presentation of a GIST which we believe to be academically interesting.
Topics: Aged; Humans; Male; Abscess; Gastrointestinal Stromal Tumors; Gastrointestinal Neoplasms
PubMed: 35255697
DOI: 10.17235/reed.2022.8580/2022 -
La Revue de Medecine Interne Aug 2020Prostatic abscesses are usually diagnosed in the setting of bacterial prostatitis. Rarely, they reveal or complicate granulomatous prostatitis.
INTRODUCTION
Prostatic abscesses are usually diagnosed in the setting of bacterial prostatitis. Rarely, they reveal or complicate granulomatous prostatitis.
CASE REPORT
A 55-year-old man was admitted for acute urinary retention. Urine culture was sterile, with leukocyturia > 10/ml. After failure of antibiotic therapy with cefotaxime, CT scan revealed a necrotic prostatic collection and a nodular non-necrotic tissular lesion in the left upper lung lobe. Trans-rectal drainage of the prostatic lesion and lung biopsies revealed granuloma with multinucleated giant cells (without mycobacteria). The diagnosis of granulomatosis with polyangiitis was confirmed by high level of anti-proteinase 3 antibodies. Treatment with steroids and rituximab resulted in apyrexia, regression of the inflammatory syndrome and clinical manifestations.
CONCLUSION
The diagnosis of granulomatosis with polyangiitis should be considered in the presence of a non-infectious granulomatous prostatitis with systemic involvement.
Topics: Abscess; Glucocorticoids; Granulomatosis with Polyangiitis; Humans; Male; Middle Aged; Prostatitis; Rituximab; Urinary Retention
PubMed: 32674890
DOI: 10.1016/j.revmed.2020.05.019