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Journal of Cosmetic Dermatology Apr 2021Acne is a chronic inflammatory skin condition seen commonly in adolescence and young adulthood. Despite being a frequent and nonthreatening life condition, acne has a... (Review)
Review
INTRODUCTION
Acne is a chronic inflammatory skin condition seen commonly in adolescence and young adulthood. Despite being a frequent and nonthreatening life condition, acne has a significant psychological impact and comorbidity.
AIMS
This review will describe prevalence, common clinical features, different clinical presentations, differential diagnoses, and treatment recommendation. Special focus has been put on psychological aspects.
METHODS
We conducted a literature search on PubMed from January 2001 to June 2020 with the search terms of Acne vulgaris, psychological, adolescents, anxiety, suicide, mood disorders. Reference lists of identified articles were examined for further relevant studies. The search was limited to English language articles. No specified quality criteria were used for study inclusion.
RESULTS
The clinical manifestations of acne are very important in the differential diagnosis and its psychological implications.
CONCLUSION
Through this article, we conclude that despite being a frequent and nonthreatening life condition, acne has a significant psychological impact which requires effective treatment to improve the patient's skin and self-esteem.
Topics: Acne Vulgaris; Adolescent; Adult; Anxiety; Comorbidity; Humans; Self Concept; Suicide; Young Adult
PubMed: 33031607
DOI: 10.1111/jocd.13765 -
Boletin Medico Del Hospital Infantil de... 2021Neonatal acne (NA) is a transitory dermatosis that occurs between the second and fourth weeks of life in 20% of children. This condition is more frequent in males, with...
Neonatal acne (NA) is a transitory dermatosis that occurs between the second and fourth weeks of life in 20% of children. This condition is more frequent in males, with a male-female ratio of 4.5:1. Present primary skin lesions are open and closed comedones which can evolve into papules, erythematous pustules and, in rare cases, nodules and cysts. NA topography includes the forehead, cheeks, chin, and eyelids, but occasionally it spreads to the scalp, neck, and trunk. NA occurs due to an elevated production of placental and neonatal androgens (of adrenal origin in both sexes and of testicular origin in males) which cause enlargement of the sebaceous glands and increases the production of sebum. Most cases are mild and transient, but if NA is severe and long-lasting, clinical and paraclinical examination will be necessary to find congenital adrenal hyperplasia or a virilizing tumor of adrenal or gonadal origin. The diagnosis of NA is clinical; its main differential -diagnoses are neonatal cephalic pustulosis, other neonatal vesiculopustular dermatoses, infectious diseases, and acneiform reactions. The resolution of NA is spontaneous. In most cases, the use of a mild dermal cleanser and water will be sufficient. For comedogenic lesions (open and closed comedones), topical retinoids or 20% azelaic acid may be used, as well as some topical antibiotics for inflammatory lesions.
Topics: Acne Vulgaris; Anti-Bacterial Agents; Child; Diagnosis, Differential; Female; Humans; Infant, Newborn; Male; Placenta; Pregnancy; Skin Diseases
PubMed: 34571513
DOI: 10.24875/BMHIM.20000327 -
Journal of the European Academy of... Jun 2015Acne is a common skin disease with a high prevalence in adolescents and young adults. In addition to physical effects such as permanent scarring and disfigurement, acne... (Review)
Review
Acne is a common skin disease with a high prevalence in adolescents and young adults. In addition to physical effects such as permanent scarring and disfigurement, acne has long-lasting psychosocial effects that affect the patient's quality of life. Depression, social isolation and suicidal ideation are frequent comorbidities of acne that should not be neglected in the therapy of acne patients. Research evidence suggests that the impairment of quality of life can be alleviated by appropriate topical acne treatment.
Topics: Acne Vulgaris; Adolescent; Anxiety; Depression; Facial Dermatoses; Humans; Quality of Life; Young Adult
PubMed: 26059729
DOI: 10.1111/jdv.13191 -
Pediatric Dermatology Jul 2022Acne vulgaris varies in clinical severity, from minimal comedonal disease to severe hemorrhagic and ulcerative lesions with scarring. While a family history confers a...
BACKGROUND
Acne vulgaris varies in clinical severity, from minimal comedonal disease to severe hemorrhagic and ulcerative lesions with scarring. While a family history confers a higher risk for developing acne, the correlation between heritability and clinical severity remains unclear.
OBJECTIVE
To examine the natural history and heritability of severe acne with scarring in patients undergoing isotretinoin therapy.
METHODS
A total of 101 subjects with severe acne with scarring and its variants, including acne conglobata and acne fulminans, were enrolled. All subjects and adult family members underwent an interview regarding their acne, and a corresponding "historical" Investigator's Global Assessment (hIGA) score (0 = clear, 1 = almost clear, 2 = mild, 3 = moderate, 4 = severe, 5 = very severe) was assigned. Study assessors performed an "examination" Investigator's Global Assessment (eIGA) based on the clinical examination of each subject (0 = clear, 1 = almost clear, 2 = mild, 3 = moderate, 4 = severe, 5 = very severe). A detailed family history and pedigree were documented.
RESULTS
Most subjects were Caucasian (44.5%) and male (79.2%) who had previously used doxycycline and/or minocycline (86.1%). The mean eIGA and hIGA scores were 2.7 and 4.4, respectively. 37.2% of subjects had one first-degree relative with a history of moderate or severe acne with scarring; of note, of the patients with hemorrhagic disease, 30% had at least one parent with moderate or severe acne.
CONCLUSIONS
Severe forms of acne often "cluster" in families, underscoring the heritable nature of acne and the prognostic value of a family history of moderate or severe disease.
Topics: Acne Vulgaris; Adult; Cicatrix; Doxycycline; Female; Humans; Isotretinoin; Male; Minocycline; Treatment Outcome
PubMed: 35584791
DOI: 10.1111/pde.14990 -
Seminars in Cutaneous Medicine and... Jun 2016Physical modalities provide an important adjunct to medical treatment of acne and rosacea. In patients who cannot tolerate or fail medical treatments, physical... (Review)
Review
Physical modalities provide an important adjunct to medical treatment of acne and rosacea. In patients who cannot tolerate or fail medical treatments, physical modalities offer an alternative approach. For cases of acne scarring, phymatous changes of rosacea, and rosacea-associated telangiectasia, physical modalities such as laser and light treatments represent the treatment of choice. We will review the use of laser and light treatments, photodynamic therapy, and other physical modalities such as targeted therapies for the treatment of acne and rosacea.
Topics: Acne Vulgaris; Humans; Laser Therapy; Photochemotherapy; Phototherapy; Rosacea; Treatment Outcome
PubMed: 27416315
DOI: 10.12788/j.sder.2016.028 -
Journal of Microbiology and... Nov 2022Acne is a chronic inflammatory disease of the sebaceous gland attached to the hair follicles. is a major cause of inflammation caused by acne. It is well known that...
Acne is a chronic inflammatory disease of the sebaceous gland attached to the hair follicles. is a major cause of inflammation caused by acne. It is well known that secretes a lipolytic enzyme to break down lipids in sebum, and free fatty acids produced at this time accelerate the inflammatory reaction. There are several drugs used to treat acne; however, each one has various side effects. According to previous studies, sulforaphene (SFEN) has several functions associated with lipid metabolism, brain function, and antibacterial and anti-inflammatory activities. In this study, we examined the effects of SFEN on bacterial growth and inflammatory cytokine production induced by . The results revealed that SFEN reduced the growth of and inhibited proinflammatory cytokines in -treated HaCaT keratinocytes through inhibiting NF-κB-related pathways. In addition, SFEN regulated the expression level of IL-1α, a representative pro-inflammatory cytokine expressed in co-cultured HaCaT keratinocytes and THP-1 monocytes induced by . In conclusion, SFEN showed antibacterial activity against and controlled the inflammatory response on keratinocytes and monocytes. This finding means that SFEN has potential as both a cosmetic material for acne prevention and a pharmaceutical material for acne treatment.
Topics: Humans; Propionibacterium acnes; Inflammation; Acne Vulgaris; Anti-Bacterial Agents
PubMed: 36437519
DOI: 10.4014/jmb.2209.09051 -
Journal of Cosmetic Dermatology Sep 2023The popularity of social media appears to be increasing the acceptance of cosmetic treatments, prompting more consumers to seek cosmetic treatments. As the estimated... (Review)
Review
BACKGROUND
The popularity of social media appears to be increasing the acceptance of cosmetic treatments, prompting more consumers to seek cosmetic treatments. As the estimated prevalence of acne vulgaris among adult women may be as high as 54%, acne is commonly observed among patients presenting for cosmetic treatments. Concomitant treatment of acne in the aesthetic patient population will improve overall clinical outcomes.
AIMS
The goal of this work was to deliver a high-quality ethical and evidence-based educational program to physicians and adjunctive health care providers to advance patient care.
METHODS
This paper is based on a webcam presentation with roundtable discussion by several notable experts in their field.
RESULTS
A range of topical medications, injectable products, chemical peels, and energy-based devices are available for treating acne vulgaris. In most instances, these are compatible with rejuvenation procedures in the aesthetic patient.
CONCLUSION
The growth of social media is raising awareness of aesthetic procedures and appears to be increasing the number of patients seeking aesthetic treatment. Educating patients about the importance of treating acne vulgaris can improve overall treatment outcomes. In most instances, the presence of acne is not a barrier to aesthetic care.
Topics: Adult; Humans; Female; Acne Vulgaris; Chemexfoliation; Dermabrasion; Treatment Outcome; Esthetics
PubMed: 37403516
DOI: 10.1111/jocd.15913 -
The British Journal of Dermatology Oct 2019Acne vulgaris is a highly prevalent inflammatory skin disorder with a complex pathogenesis, characterized by comedones, papules, pustules and nodules. Familial... (Review)
Review
BACKGROUND
Acne vulgaris is a highly prevalent inflammatory skin disorder with a complex pathogenesis, characterized by comedones, papules, pustules and nodules. Familial preponderance clearly indicates a genetic basis for acne vulgaris, but until recently solid genetic associations were lacking.
RESULTS
The advent of high-resolution genotyping array technologies has allowed for large-scale studies with both family-based and cross-sectional designs. These studies have revealed genetic loci encompassing genes that could be active in biological pathways and processes underlying acne vulgaris. However, specific functional consequences of those variants remain elusive. In parallel, investigations into rare disorders and syndromes that incorporate features of acne or acne-like lesions have recently accelerated our understanding of disease pathogenesis. The genes revealed by these rare disorders highlight mechanisms cardinal for pilosebaceous biology and therefore anchor our insights from genetic association studies for acne vulgaris.
CONCLUSIONS
The next phase of research will require more in-depth mechanistic investigations of loci and genes implicated in acne phenotypes to define the key molecular players driving the disorder. Concurrently, new treatments for acne vulgaris could be developed by dissecting the candidate molecular pathways to identify druggable targets.
Topics: Acne Vulgaris; Dermatologic Agents; Genetic Association Studies; Genetic Loci; Genetic Predisposition to Disease; Humans; Medical History Taking; Molecular Targeted Therapy; Precision Medicine; Signal Transduction; Skin
PubMed: 30854635
DOI: 10.1111/bjd.17721 -
Journal of the European Academy of... Jun 2015
Topics: Acne Vulgaris; Humans; Quality of Life
PubMed: 26059727
DOI: 10.1111/jdv.13182 -
Advances in Skin & Wound Care Feb 2024To review the clinical presentation and treatment of acne vulgaris.
GENERAL PURPOSE
To review the clinical presentation and treatment of acne vulgaris.
TARGET AUDIENCE
This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and registered nurses with an interest in skin and wound care.
LEARNING OBJECTIVES/OUTCOMES
After participating in this educational activity, the participant will:1. Identify a differential diagnosis of acne vulgaris.2. Recognize clinical feature of various acne vulgaris subtypes.3. Specify epidemiologic characteristics of acne vulgaris.4. Select topical, systemic, and nonpharmaceutical treatment options for a patient with acne vulgaris.
Topics: Humans; Acne Vulgaris; Administration, Topical; Education, Continuing; Diagnosis, Differential
PubMed: 38241449
DOI: 10.1097/ASW.0000000000000089