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A "Boil" Being the Clue to Think beyond Typical Bacterial Pathogens in Community-Acquired Pneumonia.Case Reports in Pediatrics 2022Empyema necessitans is an exceptionally rare complication of bacterial pneumonia in the pediatric population. It occurs when the infection extends from the lung...
Empyema necessitans is an exceptionally rare complication of bacterial pneumonia in the pediatric population. It occurs when the infection extends from the lung parenchyma to the chest wall by forming a fistula, which leads to infection of the surrounding soft tissue. In this case, a 13-year-old boy is found to have empyema necessitans caused by , with a preceding clue to the diagnosis being that he was treated for a superficial chest wall abscess several weeks prior to developing significant respiratory symptoms. Providers should be aware of this entity as it requires obtaining cultures to identify the appropriate pathogen and avoid treatment failure as it has implications for antibiotic choice and length of therapy.
PubMed: 35391757
DOI: 10.1155/2022/8984170 -
Journal of Clinical Microbiology Jun 2015
Topics: Actinomyces; Actinomycosis; Earache; Female; Humans; Maxillary Sinus; Maxillary Sinusitis; Middle Aged
PubMed: 25976898
DOI: 10.1128/JCM.01588-13 -
Revista Espanola de Geriatria Y... 2016
Topics: Actinomyces; Actinomycosis; Aged, 80 and over; Empyema; Humans; Pneumonia
PubMed: 26253035
DOI: 10.1016/j.regg.2015.06.007 -
La Revue de Medecine Interne Mar 2021Dermatological manifestations of actinomycosis are classical, most often related to Actinomyces israelii. In most of the cases, they occur near to the primary focus, and... (Review)
Review
INTRODUCTION
Dermatological manifestations of actinomycosis are classical, most often related to Actinomyces israelii. In most of the cases, they occur near to the primary focus, and in the cervicofacial area. Systemic dissemination with cutaneous distant metastasis is rare, most often related to A. israelii, too. We report an original case of upper limb actinomycosis associated with an oral localisation and due to an unusual bacteria.
CASE REPORT
A 49-year-old man was referred to the Department of dermatology for a skin lesion of the left hand and wrist. Biopsies revealed actinomycosis related to A. meyeri. Dental primary focus was identified and treated. Although the patient was lost sight of, dental eradication and prolonged antibiotics therapy allowed cutaneous improvement.
DISCUSSION
We report an atypical case of cutaneous actinomycosis due to an Actinomyces meyeri dental infection occurring in an immunocompetent, smoking adult, with poor oral hygiene. The literature review revealed only 4 well-documented cases of cutaneous A. meyeri infections distant to dental primary focus. All of patients were males, immunocompetent, with a history of poor oral hygiene. The prognosis is favourable with adequate treatment (antibiotic therapy and surgical treatment to eradicate dental infectious entry points).
Topics: Actinomyces; Actinomycetaceae; Actinomycosis; Adult; Humans; Male; Middle Aged; Skin Diseases, Bacterial
PubMed: 33303221
DOI: 10.1016/j.revmed.2020.11.011 -
Journal of Human Genetics Mar 2021Ancient DNA studies provide genomic information about the origins, population structures, and physical characteristics of ancient humans that cannot be solely examined... (Comparative Study)
Comparative Study
Ancient DNA studies provide genomic information about the origins, population structures, and physical characteristics of ancient humans that cannot be solely examined by archeological studies. The DNAs extracted from ancient human bones, teeth, or tissues are often contaminated with coexisting bacterial and viral genomes that contain DNA from ancient microbes infecting those of ancient humans. Information on ancient viral genomes is useful in making inferences about the viral evolution. Here, we have utilized metagenomic sequencing data from the dental pulp of five Jomon individuals, who lived on the Japanese archipelago more than 3000 years ago; this is to detect ancient viral genomes. We conducted de novo assembly of the non-human reads where we have obtained 277,387 contigs that were longer than 1000 bp. These contigs were subjected to homology searches against a collection of modern viral genome sequences. We were able to detect eleven putative ancient viral genomes. Among them, we reconstructed the complete sequence of the Siphovirus contig89 (CT89) viral genome. The Jomon CT89-like sequence was determined to contain 59 open reading frames, among which five genes known to encode phage proteins were under strong purifying selection. The host of CT89 was predicted to be Schaalia meyeri, a bacterium residing in the human oral cavity. Finally, the CT89 phylogenetic tree showed two clusters, from both of which the Jomon sequence was separated. Our results suggest that metagenomic information from the dental pulp of the Jomon people is essential in retrieving ancient viral genomes used to examine their evolution.
Topics: Actinomycetaceae; Asian People; Clustered Regularly Interspaced Short Palindromic Repeats; Contig Mapping; DNA, Viral; Dental Pulp; Ethnicity; Female; Fossils; Genome, Viral; History, Ancient; Humans; Japan; Likelihood Functions; Male; Metagenome; Molecular Sequence Annotation; Mouth; Open Reading Frames; Phylogeny; Sequence Alignment; Sequence Homology, Nucleic Acid; Siphoviridae; Whole Genome Sequencing
PubMed: 32994538
DOI: 10.1038/s10038-020-00841-6 -
Anaerobe Feb 2018We report the case of a 69-year-old man admitted for septic shock secondary to necrotic pneumoniae complicated by thoracic empyema of fatal issue. Microbiological...
We report the case of a 69-year-old man admitted for septic shock secondary to necrotic pneumoniae complicated by thoracic empyema of fatal issue. Microbiological examination of pleural liquid revealed a mixed anaerobic flora involving Campylobacter rectus and Actinomyces meyeri. Campylobacter rectus is an infrequent anaerobic pathogen of oral origin To our knowledge, this is the first case report of fatal C. rectus - associated thoracic empyema, and only the second reported case in which identification was successfully performed by MALDI-TOF MS.
Topics: Aged; Anti-Bacterial Agents; Campylobacter Infections; Campylobacter rectus; Empyema, Pleural; Fatal Outcome; Humans; Male
PubMed: 29325875
DOI: 10.1016/j.anaerobe.2017.12.014 -
Archivos Argentinos de Pediatria Dec 2015Actinomycosis is a disease produced by bacteria of the genus Actinomyces. The thoracic form represents 30% of the cases. Signs and symptoms are generally unspecific. A...
Actinomycosis is a disease produced by bacteria of the genus Actinomyces. The thoracic form represents 30% of the cases. Signs and symptoms are generally unspecific. A previously healthy 11 year old girl was admitted with a chest mass of a month of evolution associated with fever, hyporexia and weight loss. Thoracic actinomycosis was diagnosed with the isolation of Actinomyces meyeri in the mass drainage. She received antibiotic treatment for a year with complete resolution. Although rare, it should be taken into account as a differential diagnosis in long evolution thoracic tumor affecting the general condition. The microbiologist must be warned about the suspected diagnosis because it is difficult to find it in routinely used culture media.
Topics: Actinomyces; Actinomycosis; Child; Female; Humans; Lung Diseases
PubMed: 26593814
DOI: 10.5546/aap.2015.e345 -
Journal of Applied Oral Science :... 2015Phosphoric acid has been suggested as an irrigant due to its effectiveness in removing the smear layer. (Comparative Study)
Comparative Study
UNLABELLED
Phosphoric acid has been suggested as an irrigant due to its effectiveness in removing the smear layer.
OBJECTIVES
The purpose of this study was to compare the antimicrobial and cytotoxic effects of a 37% phosphoric acid solution to other irrigants commonly used in endodontics.
MATERIAL AND METHODS
The substances 37% phosphoric acid, 17% EDTA, 10% citric acid, 2% chlorhexidine (solution and gel), and 5.25% NaOCl were evaluated. The antimicrobial activity was tested against Candida albicans, Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Actinomyces meyeri, Parvimonas micra, Porphyromonas gingivalis, and Prevotella nigrescens according to the agar diffusion method. The cytotoxicity of the irrigants was determined by using the MTT assay.
RESULTS
Phosphoric acid presented higher antimicrobial activity compared to the other tested irrigants. With regard to the cell viability, this solution showed results similar to those with 5.25% NaOCl and 2% chlorhexidine (gel and solution), whereas 17% EDTA and 10% citric acid showed higher cell viability compared to other irrigants.
CONCLUSION
Phosphoric acid demonstrated higher antimicrobial activity and cytotoxicity similar to that of 5.25% NaOCl and 2% chlorhexidine (gel and solution).
Topics: Animals; Anti-Infective Agents; BALB 3T3 Cells; Bacteria; Candida albicans; Cell Survival; Chlorhexidine; Citric Acid; Colony Count, Microbial; Cytotoxins; Edetic Acid; Materials Testing; Mice; Microbial Sensitivity Tests; Phosphoric Acids; Root Canal Irrigants; Sodium Hypochlorite; Time Factors
PubMed: 26018307
DOI: 10.1590/1678-775720130691 -
Journal of Intensive Care 2014The objective of this case report is to describe the first case of renal actinomycosis caused by Actinomyces meyeri presenting as severe emphysematous pyelonephritis and...
The objective of this case report is to describe the first case of renal actinomycosis caused by Actinomyces meyeri presenting as severe emphysematous pyelonephritis and complicated by septic shock and multi-organ failure. Emphysematous pyelonephritis is a potentially life-threatening infection mostly described in diabetic patients and predominantly caused by uropathogenic bacteria. Actinomycosis is an uncommon chronic infection due to anaerobic gram-positive bacteria that unusually involves the urinary tract. We report the first case of emphysematous pyelonephritis caused by A. meyeri in a 75-year-old non-diabetic woman. The patient presented with an altered status, fever, nausea, and vomiting lasting for 2 days. A computed tomography scan revealed unilateral emphysematous pyelonephritis. She was rapidly admitted to intensive care unit for a septic shock with multiple organ dysfunctions. A conservative management consisting in renal percutaneous drainage, supportive measures, and prolonged adapted antibiotic therapy resulted in complete recovery. This case report illustrates that renal actinomycosis should be considered in case of emphysematous pyelonephritis given the good prognosis of this infection with conservative medical treatment.
PubMed: 25878793
DOI: 10.1186/2052-0492-2-42 -
Revue Des Maladies Respiratoires May 2015A patient with a history of squamous cell carcinoma of the right upper lung lobe treated 14 years before by concomitant chemo-radiotherapy was referred on account of...
A patient with a history of squamous cell carcinoma of the right upper lung lobe treated 14 years before by concomitant chemo-radiotherapy was referred on account of dyspnea. Bronchial endoscopy revealed complete obstruction of the right main bronchus highly suggestive of a tumor recurrence. However, biopsy samples only showed inflammatory and necrotic tissue with no evidence of malignancy. Despite complete tissue resection by rigid bronchoscopy, a rapid and complete recurrence occurred requiring the placement of a Y-shaped bronchial prosthesis. Repeat histological, bacteriological and mycological analyses were negative. The patient was soon readmitted to hospital for a lung infection due to recurrence of obstruction inside and around the prosthesis. Bacterial examination of biopsy samples identified Actinomyces meyeri. Appropriate antibiotic therapy led to a complete regression of the bronchial obstruction. Unfortunately, the patient died a few months later due to massive hemoptysis after the removal of the prosthesis. Autopsy examination showed a fistula between the right main bronchus and pulmonary artery, with no evidence of neoplastic recurrence nor the persistence of lesions associated with actinomycosis.
Topics: Actinomycosis; Aged; Airway Obstruction; Biopsy; Bronchial Fistula; Bronchoscopy; Carcinoma, Squamous Cell; Chemoradiotherapy; Device Removal; Diagnosis, Differential; Fatal Outcome; Hemoptysis; Humans; Lung Diseases, Fungal; Lung Neoplasms; Male; Necrosis; Neoplasm Recurrence, Local; Postoperative Complications; Prosthesis Implantation; Pulmonary Artery; Time Factors; Vascular Fistula
PubMed: 26024827
DOI: 10.1016/j.rmr.2014.10.732