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Advances in Experimental Medicine and... 2018Under low nonfreezing temperature conditions, plants from temperate climates undergo physiological and biochemical adjustments that increase their tolerance to freezing... (Review)
Review
Under low nonfreezing temperature conditions, plants from temperate climates undergo physiological and biochemical adjustments that increase their tolerance to freezing temperatures. This response, termed cold acclimation, is largely regulated by changes in gene expression. Molecular and genetic studies have identified a small family of transcription factors, called C-repeat binding factors (CBFs), as key regulators of the transcriptomic rearrangement that leads to cold acclimation. The function of these proteins is tightly controlled, and an inadequate supply of CBF activity may be detrimental to the plant. Accumulated evidence has revealed an extremely intricate network of positive and negative regulators of cold acclimation that coalesce at the level of CBF promoters constituting a central hub where multiple internal and external signals are integrated. Moreover, CBF expression is also controlled at posttranscriptional and posttranslational levels further refining CBF regulation. Recently, natural variation studies in Arabidopsis have demonstrated that mutations resulting in changes in CBF expression have an adaptive value for wild populations. Intriguingly, CBF genes are also present in plant species that do not cold acclimate, which suggest that they may also have additional functions. For instance, CBFs are required for some cold-related abiotic stress responses. In addition, their involvement in plant development deserves further study. Although more studies are necessary to fully harness CBF biotechnological potential, these transcription factors are meant to be key for a rational design of crops with enhanced tolerance to abiotic stress.
Topics: Acclimatization; Arabidopsis; Arabidopsis Proteins; Cold Temperature; Cold-Shock Response; Core Binding Factors; Gene Expression Regulation, Plant; Gene Regulatory Networks; Genes, Plant; Genotype; Phenotype; Promoter Regions, Genetic; Signal Transduction
PubMed: 30288701
DOI: 10.1007/978-981-13-1244-1_1 -
Trends in Ecology & Evolution Sep 2016During times of rapid environmental change, survival of most vertebrate populations depends on their phenomic plasticity. Although differential gene-expression and... (Review)
Review
During times of rapid environmental change, survival of most vertebrate populations depends on their phenomic plasticity. Although differential gene-expression and post-transcriptional processes of the host genome receive focus as the main molecular mechanisms, growing evidence points to the gut microbiota as a key driver defining hosts' phenotypes. We propose that the plasticity of the gut microbiota might be an essential factor determining phenomic plasticity of vertebrates, and that it might play a pivotal role when vertebrates acclimate and adapt to fast environmental variation. We contemplate some key questions and suggest methodological approaches and experimental designs that can be used to evaluate whether gut microorganisms provide a boost of plasticity to vertebrates' phenomes, thereby increasing their acclimation and adaptation capacity.
Topics: Acclimatization; Adaptation, Physiological; Animals; Ecology; Metagenome; Vertebrates
PubMed: 27453351
DOI: 10.1016/j.tree.2016.06.008 -
The Journal of Physiology Feb 2023In recent years, there has been an explosion of new approaches (technological, methodological, pharmacological, etc.) designed to improve physical performance for... (Review)
Review
In recent years, there has been an explosion of new approaches (technological, methodological, pharmacological, etc.) designed to improve physical performance for athletes, the military and in other applications. The goal of the present discussion is to review and quantify several ways in which physiology can provide important insights about which tools may lead to improved performance (and may therefore be worth resource investment) and which tools are less likely to provide meaningful enhancement. To address these objectives, we review examples of technological solutions/approaches in terms of the magnitude of their potential (or actual) influences: transformational, moderate, ineffective or undetermined. As one example, if there were a technology which significantly increased arterial oxygen partial pressure by 10%, this would be relatively meaningless in healthy people resting at sea level, where it would have a minimal effect on arterial oxygen content. However, there might be specific situations where such an effect would be very helpful, including at high altitude or in some patient populations. We discuss the importance of quantitative evaluation of putative approaches to performance enhancement and highlight the important role of integrative physiologists in the development and critical appraisal of these approaches.
Topics: Humans; Altitude; Hypoxia; Acclimatization; Oxygen Consumption; Oxygen; Physical Endurance
PubMed: 36518016
DOI: 10.1113/JP283975 -
The Science of the Total Environment Dec 2020Demographic trends will play a role in determining the magnitude of climate disruption and the ability of societies to adapt to it. Yet policy makers largely ignore the... (Review)
Review
Demographic trends will play a role in determining the magnitude of climate disruption and the ability of societies to adapt to it. Yet policy makers largely ignore the potential of fertility changes and population growth when designing policies to limit climate disruption and lessen its impacts. Here we argue that rights-based policy interventions could decrease fertility rates to levels consistent with low population pathways. We review country and global level studies that explore the effects of low population pathways on climate change mitigation and adaptation. We then provide rights-based policy recommendations, such as the expansion of voluntary family planning programs that incorporate elements from successful past programs, and highlight current research gaps. In concert with policies that end fossil fuel use and incentivize sustainable consumption, humane policies that slow population growth should be part of a multifaceted climate response. These policies require attention from scientists, policy analysts and politicians.
Topics: Acclimatization; Birth Rate; Climate Change; Fertility; Population Growth
PubMed: 33113687
DOI: 10.1016/j.scitotenv.2020.141346 -
Nature Plants Apr 2020Predicting the consequences of manipulating genotype (G) and agronomic management (M) on agricultural ecosystem performances under future environmental (E) conditions... (Review)
Review
Predicting the consequences of manipulating genotype (G) and agronomic management (M) on agricultural ecosystem performances under future environmental (E) conditions remains a challenge. Crop modelling has the potential to enable society to assess the efficacy of G × M technologies to mitigate and adapt crop production systems to climate change. Despite recent achievements, dedicated research to develop and improve modelling capabilities from gene to global scales is needed to provide guidance on designing G × M adaptation strategies with full consideration of their impacts on both crop productivity and ecosystem sustainability under varying climatic conditions. Opportunities to advance the multiscale crop modelling framework include representing crop genetic traits, interfacing crop models with large-scale models, improving the representation of physiological responses to climate change and management practices, closing data gaps and harnessing multisource data to improve model predictability and enable identification of emergent relationships. A fundamental challenge in multiscale prediction is the balance between process details required to assess the intervention and predictability of the system at the scales feasible to measure the impact. An advanced multiscale crop modelling framework will enable a gene-to-farm design of resilient and sustainable crop production systems under a changing climate at regional-to-global scales.
Topics: Acclimatization; Climate Change; Crops, Agricultural; Models, Biological
PubMed: 32296143
DOI: 10.1038/s41477-020-0625-3 -
Planta Jul 2021An overview is presented of recent advances in our knowledge of responses and mechanisms rendering adaptation to saline conditions in sorghum. Different strategies... (Review)
Review
An overview is presented of recent advances in our knowledge of responses and mechanisms rendering adaptation to saline conditions in sorghum. Different strategies deployed to enhance salinity stress tolerance in sorghum are also pointed out. Salinity stress is a growing problem worldwide. Sorghum is the fifth key crop among cereals. Understanding responses and tolerance strategies in sorghum would be therefore helpful effort for providing biomarkers for designing greatest salinity-tolerant sorghum genotypes. When sorghum exposed to salinity, salinity-tolerant genotypes most probably reprogram their gene expression to activate adaptive biochemical and physiological responses for survival. The review thus discusses the possible physiological and biochemical responses that confer salinity tolerance to sorghum under saline conditions. Although it is not characterized in sorghum, salinity perceiving and transmitting signals to downstream responses via signaling transduction pathways most likely are essential strategy for sorghum adaptation to salinity stress. Sorghum has also shown to withstand moderate saline environments and retain the germination, growth, and photosynthetic activities. Salinity-tolerant sorghum genotypes show the ability to exclude excessive Na from reaching shoots and induce ion homeostasis. Osmotic homeostasis and ROS detoxification are also evident as salinity tolerance strategies in sorghum. These above mechanisms lead to re-establishment of cellular ionic, osmotic, and redox homeostasis as well as photosynthesis efficiency. It is noteworthy that these mechanisms act individually or co-operatively to minimize the salinity hazards and enhance acclimation in sorghum. We conclude, however, that although these responses contribute to sorghum tolerance to salinity stress, they seem to be not adequate at higher concentrations of salinity, which agrees with sorghum ranking as moderately salinity-tolerant crop. Also, some of these tolerance strategies reported in other crops are not well studied and documented in sorghum, but most probably have roles in sorghum. Further improvement in sorghum salinity tolerance using different approaches is definitely necessary to meet the requirements of its harsh production environments, and therefore, these approaches are addressed.
Topics: Edible Grain; Salinity; Salt Stress; Salt Tolerance; Sorghum
PubMed: 34224010
DOI: 10.1007/s00425-021-03671-8 -
Sports Medicine (Auckland, N.Z.) Nov 2016Exercise training (ExT) prompts multiple beneficial adaptations associated with vascular health, such as increases in skeletal muscle capillarization and vascular... (Meta-Analysis)
Meta-Analysis Review
BACKGROUND
Exercise training (ExT) prompts multiple beneficial adaptations associated with vascular health, such as increases in skeletal muscle capillarization and vascular dilator function and decreases in arterial stiffness. However, whether ExT performed in hypoxic conditions induces enhanced effects is unclear.
OBJECTIVE
We sought to systematically review the literature and determine whether hypoxic ExT leads to superior vascular adaptations compared with normoxic ExT.
METHODS
We searched MEDLINE, Scopus, and Web of Science from their inception until September 2015 for articles assessing vascular adaptations to ExT performed under hypoxic and normoxic conditions. We performed meta-analyses to determine the standardized mean difference (SMD) between the effects of ExT performed in hypoxia versus normoxia on vascular adaptations. We assessed heterogeneity among studies using I statistics and evaluated publication bias via the Begg and Mazumdar's rank correlation test and Egger's regression test.
RESULTS
After systematic review, we included 21 controlled studies, including a total of 331 individuals (mean age 19-57 years, 265 males). ExT programs primarily consisted of cycling endurance training performed in normobaric hypoxia or normoxia; duration ranged from 3 to 10 weeks. The exercise intensity was similar in relative terms in the groups trained in hypoxia and normoxia in the majority of studies (17 of 21). After data pooling, skeletal muscle capillarization (n = 182, SMD = 0.40, 95 % confidence interval [CI] 0.10-0.70; P = 0.01) and vascular dilator function (n = 71, SMD = 0.67, 95 % CI 0.17-1.18; P = 0.009) but not arterial stiffness (n = 112, SMD = -0.03, 95 % CI -0.69 to 0.63; P = 0.93), were enhanced with ExT performed in hypoxia versus normoxia. We only found heterogeneity among studies assessing arterial stiffness (I = 63 %, P = 0.02), and no publication bias was detected.
CONCLUSION
Based on current published studies, hypoxic ExT potentiates vascular adaptations related to skeletal muscle capillarization and dilator function. These findings may contribute to establishing effective exercise programs designed to enhance vascular health.
Topics: Acclimatization; Adult; Exercise; Humans; Hypoxia; Male; Middle Aged; Muscle, Skeletal; Oxygen Consumption; Vascular Stiffness; Young Adult
PubMed: 27286988
DOI: 10.1007/s40279-016-0570-5 -
Biochimica Et Biophysica Acta Aug 2016Every year, environmental stresses such as limited water and nutrient availability, salinity, and temperature fluctuations inflict significant losses on crop yields... (Review)
Review
BACKGROUND
Every year, environmental stresses such as limited water and nutrient availability, salinity, and temperature fluctuations inflict significant losses on crop yields across the globe. Recently, developments in analytical techniques, e.g. mass spectrometry, have led to great advances towards understanding how plants respond to environmental stresses. These processes are mediated by many molecular pathways and, at least partially, via proteome-environment interactions.
SCOPE OF REVIEW
This review focuses on the current state of knowledge about interactions between the plant proteome and the environment, with a special focus on drought and temperature responses of plant proteome dynamics, and subcellular and organ-specific compartmentalization, in Arabidopsis thaliana and crop species.
MAJOR CONCLUSIONS
Correct plant development under non-optimal conditions requires complex self-protection mechanisms, many of them common to different abiotic stresses. Proteome analyses of plant responses to temperature and drought stresses have revealed an intriguing interplay of modifications, mainly affecting the photosynthetic machinery, carbohydrate metabolism, and ROS activation and scavenging. Imbalances between transcript-level and protein-level regulation observed during adaptation to abiotic stresses suggest that many of the regulatory processes are controlled at translational and post-translational levels; proteomics is thus essential in revealing important regulatory networks.
GENERAL SIGNIFICANCE
Because information from proteomic data extends far beyond what can be deduced from transcriptome analysis, the results of proteome studies have substantially deepened our understanding of stress adaptation in plants; this is clearly a prerequisite for designing strategies to improve the yield and quality of crops grown under unfavorable conditions brought about by ongoing climatic change. This article is part of a Special Issue entitled: Plant Proteomics--a bridge between fundamental processes and crop production, edited by Dr. Hans-Peter Mock.
Topics: Acclimatization; Arabidopsis; Arabidopsis Proteins; Crops, Agricultural; Proteome; Stress, Physiological; Water
PubMed: 26861773
DOI: 10.1016/j.bbapap.2016.02.007 -
IEEE Transactions on Visualization and... Jan 2020Complex data visualization design projects often entail collaboration between people with different visualization-related skills. For example, many teams include both...
Complex data visualization design projects often entail collaboration between people with different visualization-related skills. For example, many teams include both designers who create new visualization designs and developers who implement the resulting visualization software. We identify gaps between data characterization tools, visualization design tools, and development platforms that pose challenges for designer-developer teams working to create new data visualizations. While it is common for commercial interaction design tools to support collaboration between designers and developers, creating data visualizations poses several unique challenges that are not supported by current tools. In particular, visualization designers must characterize and build an understanding of the underlying data, then specify layouts, data encodings, and other data-driven parameters that will be robust across many different data values. In larger teams, designers must also clearly communicate these mappings and their dependencies to developers, clients, and other collaborators. We report observations and reflections from five large multidisciplinary visualization design projects and highlight six data-specific visualization challenges for design specification and handoff. These challenges include adapting to changing data, anticipating edge cases in data, understanding technical challenges, articulating data-dependent interactions, communicating data mappings, and preserving the integrity of data mappings across iterations. Based on these observations, we identify opportunities for future tools for prototyping, testing, and communicating data-driven designs, which might contribute to more successful and collaborative data visualization design.
PubMed: 31478857
DOI: 10.1109/TVCG.2019.2934538 -
Marine Life Science & Technology Aug 2022The seas confront organisms with a suite of abiotic stressors that pose challenges for physiological activity. Variations in temperature, hydrostatic pressure, and... (Review)
Review
The seas confront organisms with a suite of abiotic stressors that pose challenges for physiological activity. Variations in temperature, hydrostatic pressure, and salinity have potential to disrupt structures, and functions of all molecular systems on which life depends. During evolution, sequences of nucleic acids and proteins are adaptively modified to "fit" these macromolecules for function under the particular abiotic conditions of the habitat. Complementing these macromolecular adaptations are alterations in compositions of solutions that bathe macromolecules and affect stabilities of their higher order structures. A primary result of these "micromolecular" adaptations is preservation of optimal balances between conformational rigidity and flexibility of macromolecules. Micromolecular adaptations involve several families of organic osmolytes, with varying effects on macromolecular stability. A given type of osmolyte generally has similar effects on DNA, RNA, proteins and membranes; thus, adaptive regulation of cellular osmolyte pools has a global effect on macromolecules. These effects are mediated largely through influences of osmolytes and macromolecules on water structure and activity. Acclimatory micromolecular responses are often critical in enabling organisms to cope with environmental changes during their lifetimes, for example, during vertical migration in the water column. A species' breadth of environmental tolerance may depend on how effectively it can vary the osmolyte composition of its cellular fluids in the face of stress. Micromolecular adaptations remain an under-appreciated aspect of evolution and acclimatization. Further study can lead to a better understanding of determinants of environmental tolerance ranges and to biotechnological advances in designing improved stabilizers for biological materials.
PubMed: 37073170
DOI: 10.1007/s42995-022-00140-3