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International Journal of Biological... Jul 2022The fabrication of hydrogel for sensing purposes remains to be a challenge since the hydrogel needs to have both good mechanical strength and adhesiveness. This work...
The fabrication of hydrogel for sensing purposes remains to be a challenge since the hydrogel needs to have both good mechanical strength and adhesiveness. This work reports a robust and adhesive hydrogel mainly constructed with AgNPs@lignin, polyacrylamide (PAM) and sodium alginate (SA). The silver nanoparticles (AgNPs) were in-situ generated via the reaction between lignin and silver ammonia ([Ag(NH)]). The resultant lignin hybrid hydrogel exhibited a stress, strain and tearing energy up to 0.055 MPa, 1000% and 250 J·m, respectively. Furthermore, the hydrogel adhered to different materials with an adhesion energy of higher than 230 J·m. This hydrogel was demonstrated to be an ideal sensing material since it could detect both large-scale motions and tiny physiological signals including breathing and pulse. The hydrogel also exhibited good antibacterial performance and biocompatibility. This work provides a good example to design a lignin-based high-performance hydrogel material for sensing purposes.
Topics: Adhesives; Anti-Bacterial Agents; Hydrogels; Lignin; Metal Nanoparticles; Silver
PubMed: 35654216
DOI: 10.1016/j.ijbiomac.2022.05.168 -
Acta Biomaterialia Dec 2021The balance between high mechanical properties and strong adhesion strength is crucial in designing and preparing a bio-based hydrogel adhesive for wound closure....
The balance between high mechanical properties and strong adhesion strength is crucial in designing and preparing a bio-based hydrogel adhesive for wound closure. Although the adhesion performance of bioadhesives has been remarkably improved by modification with catechol groups, their mechanical properties are yet to meet the biomedical requirements. In this study, mussel-inspired epoxy bioadhesives (CSD-PEG) were synthesized based on catechol-modified chitosan oligosaccharide (CSD) and polyethylene glycol diglycidyl ether (PEGDGE) through nucleophilic substitution. Notably, the CSD-PEG adhesive showed high mechanical and adhesion strengths, which were up to 50.7 kPa and 136.7 kPa, respectively. It was confirmed that a certain amount of the epoxy and catechol groups provided multiple interfacial interactions among the adhesives, substrates, and polymer chains for enhancing the performance of adhesives. The adhesives showed good binding and repairing effects for wound closure and favorable biocompatibility in vivo. The prepared CSD-PEG adhesives are expected to be a promising candidate for surgical tissue repair, wound closure, and tissue engineering fields. STATEMENT OF SIGNIFICANCE: Current reported adhesives composed of biopolymers generally suffer from poor mechanical properties or weak tissue adhesiveness. Therefore, to achieve simultaneously high mechanical and adhesion properties in a bio-based adhesive for wound closure is a big challenge. In this study, mussel-inspired adhesive hydrogels (CSD-PEG) were prepared based on catechol-modified chitosan oligosaccharide (CSD) and polyethylene glycol diglycidyl ether (PEGDGE). The tensile strength and adhesive strength of CSD-PEG on porcine skin reached 50.7 kPa and 136.7 kPa, respectively, which were higher than those for most reported biopolymeric adhesives, mainly due to the multiple interfacial interactions between the catechol and epoxy groups. The CSD-PEG bioadhesives also showed good binding and repairing effects for wound closure and tissue regeneration in vivo.
Topics: Adhesives; Animals; Hydrogels; Polymers; Swine; Tissue Adhesives; Tissue Engineering
PubMed: 34610475
DOI: 10.1016/j.actbio.2021.09.054 -
Advanced Science (Weinheim,... Aug 2021The exceptional underwater adhesive properties displayed by aquatic organisms, such as mussels (Mytilus spp.) and barnacles (Cirripedia spp.) have long inspired new...
The exceptional underwater adhesive properties displayed by aquatic organisms, such as mussels (Mytilus spp.) and barnacles (Cirripedia spp.) have long inspired new approaches to adhesives with a superior performance both in wet and dry environments. Herein, a bioinspired adhesive composite that combines both adhesion mechanisms of mussels and barnacles through a blend of silk, polydopamine, and Fe ions in an entirely organic, nontoxic water-based formulation is presented. This approach seeks to recapitulate the two distinct mechanisms that underpin the adhesion properties of the Mytilus and Cirripedia, with the former secreting sticky proteinaceous filaments called byssus while the latter produces a strong proteic cement to ensure anchoring. The composite shows remarkable adhesive properties both in dry and wet conditions, favorably comparing to synthetic commercial glues and other adhesives based on natural polymers, with performance comparable to the best underwater adhesives with the additional advantage of having an entirely biological composition that requires no synthetic procedures or processing.
Topics: Adhesives; Animals; Biocompatible Materials; Biomimetic Materials; Bivalvia; Thoracica
PubMed: 34080324
DOI: 10.1002/advs.202004786 -
Biomacromolecules Oct 2020Wound dressings are widely used to promote wound healing. Traditional dressings need the help of tape to fix onto the wounds, which are not suitable in the human body.... (Review)
Review
Wound dressings are widely used to promote wound healing. Traditional dressings need the help of tape to fix onto the wounds, which are not suitable in the human body. In addition, hemostasis of internal wounds is usually treated with direct sutures which will cause secondary trauma to the patient and increase the risk of infection. Therefore, development of new dressings with high tissue adhesion and biocompatibility is of great clinical significance. The highly adhesive wound dressings can firmly attach to external and internal wounds, and form a barrier to prevent bacterial invasion, accelerate healing, and avoid secondary damage caused by sutures. Hydrogels are soft materials that possess a 3D network structure with tunable physical and chemical properties, which provides ideal conditions to support the wound healing process. In this review, we summarize the recent advances in developing hydrogel-based wound dressings as well as their adhesion mechanism. Moreover, the prospects of these wound dressings over the coming years are also covered.
Topics: Adhesives; Bandages; Humans; Hydrogels; Tissue Adhesions; Wound Healing
PubMed: 32960043
DOI: 10.1021/acs.biomac.0c01069 -
Molecules (Basel, Switzerland) May 2019A chemical modification by grafting alkyl chains using an octanal (C8) on chitosan was conducted with the aim to improve its water resistance for bonding applications....
A chemical modification by grafting alkyl chains using an octanal (C8) on chitosan was conducted with the aim to improve its water resistance for bonding applications. The chemical structure of the modified polymers was determined by NMR analyses revealing two alkylation degrees (10 and 15%). In this study, the flow properties of alkyl-chitosans were also evaluated. An increase in the viscosity was observed in alkyl-chitosan solutions compared with solutions of the same concentration based on native chitosan. Moreover, the evaluation of the adhesive strength (bond strength and shear stress) of both native and alkyl-chitosans was performed on two different double-lap adherends (aluminum and wood). Alkyl-chitosans (10 and 15%) maintain sufficient adhesive properties on wood and exhibit better water resistance compared to native chitosan.
Topics: Adhesives; Alkylation; Chitosan; Rheology; Stress, Mechanical; Viscosity; Water; Wood
PubMed: 31126129
DOI: 10.3390/molecules24101987 -
Stomatologiia 2023This review presents an analysis of domestic and foreign literature on the issues of fixation of facial epitheses and combined maxillofacial prostheses, such as the use... (Review)
Review
This review presents an analysis of domestic and foreign literature on the issues of fixation of facial epitheses and combined maxillofacial prostheses, such as the use of craniofacial implants installed in the zygomatic bone, brow arches, orbital walls, mastoid process of the temporal bone with beam or magnetic beam fixation systems. The advantages and disadvantages of such fastening systems are described. The analysis and systematization of available data on medical adhesive compositions that can be used in maxillofacial prosthetics to hold facial epitheses has been carried out. Much attention is paid to the chemical composition of pressure-sensitive adhesives, water-based and silicone-based. Examples of such compositions are given. The physicochemical properties of medical adhesive systems that cause adhesive-cohesive interaction are described. This review presents the results of comparative studies to assess the fixing properties of various adhesives, as well as to study the formation of biofilm on the surfaces of prostheses and skin when using different adhesives.
Topics: Humans; Dental Cements; Dental Implants; Face; Maxillofacial Prosthesis; Silicones; Adhesives
PubMed: 37997315
DOI: 10.17116/stomat202310206162 -
Small (Weinheim An Der Bergstrasse,... Mar 2020Boston ivy (Parthenocissus tricuspidata) climbs brick walls using its tendril disks, which excrete a sticky substance to perform binding and attachment. While the...
Boston ivy (Parthenocissus tricuspidata) climbs brick walls using its tendril disks, which excrete a sticky substance to perform binding and attachment. While the cellular structures and adhesive substances involved have been identified for decades, their practical applicability as an adhesive has not yet been demonstrated. A Boston ivy disk-inspired adhesive film patch system is reported in which structural and compositional features of the Boston ivy disk are mimicked with a form of thin adhesive film patches. In analogy to the sticky disk of a mature ivy in which porous microchannels are occupied by catechol-containing microgranules on the bound site, 3,4-dihydroxylphenylalanine bolaamphiphile nanoparticle (DOPA-C7 NP)-coated alginate microgels are two-dimensionally positioned into the cylindrical holes that are periodically micropatterned on the flexible stencil film. Finally, it is demonstrated that the pressurization of the patch breaks the microgels filled in the holes, releasing the polysaccharides and leading to crosslinking with DOPA-C7 NPs via ligandation with combined Ca and Fe ions, thus enabling development of a pressure-mediated adhesion technology.
Topics: Adhesives; Alginates; Microgels; Plant Extracts; Pressure; Vitaceae
PubMed: 31755646
DOI: 10.1002/smll.201904282 -
AORN Journal Aug 2014Hemostats, sealants, and adhesives are an integral part of surgical patient care. Nurses who have knowledge about these agents can better help ensure safe, efficient... (Review)
Review
Hemostats, sealants, and adhesives are an integral part of surgical patient care. Nurses who have knowledge about these agents can better help ensure safe, efficient surgical patient care. As a caregiver and patient advocate, the perioperative nurse must understand the most current information about these agents and be prepared to facilitate the transfer of this knowledge to all caregivers. Information about these agents, including the contraindications, warnings, and precautions associated with their use as well as their preparation and application, is provided here. Algorithms designed to clarify the best options for using hemostats, sealants, and adhesives are included as well.
Topics: Adhesives; Fibrin Tissue Adhesive; Hemostatics; Humans; Patient Safety
PubMed: 25080417
DOI: 10.1016/j.aorn.2014.01.026 -
Journal of Materials Chemistry. B Feb 2022Hydrogel-based wound dressings with tissue adhesion abilities are widely used for wound closure. However, currently developed hydrogel adhesives are still poor at...
Hydrogel-based wound dressings with tissue adhesion abilities are widely used for wound closure. However, currently developed hydrogel adhesives are still poor at continuing to seal wounds while bleeding is ongoing. Herein, we demonstrate an antibacterial and hemostatic hydrogel adhesive with low-swelling properties and toughness for wound healing. The hydrogel was composed of Pluronic F127 diacrylate, quaternized chitosan diacrylate, silk fibroin, and tannic acid, and it was not only able to maintain good tissue adhesion abilities in a moist environment but it also showed guaranteed tissue adhesion and mechanical strength after absorbing water due to its low-swelling and toughness properties. Furthermore, and tests demonstrated that the hydrogel also had antibacterial, antioxidant, and hemostatic properties, which could promote tissue regeneration. All these findings demonstrate that this hydrogel with multifunctional properties is a promising material for clinical wound healing applications.
Topics: Adhesives; Anti-Bacterial Agents; Hemostatics; Humans; Hydrogels; Tissue Adhesions; Wound Healing
PubMed: 35050296
DOI: 10.1039/d1tb01871j -
Macromolecular Rapid Communications Mar 2023Marine-inspired phenolic compounds that exhibit underwater adhesion are used as biomedical adhesives under wet conditions. While these applications mainly use catechol... (Comparative Study)
Comparative Study
Marine-inspired phenolic compounds that exhibit underwater adhesion are used as biomedical adhesives under wet conditions. While these applications mainly use catechol and pyrogallol moieties that contain different numbers of hydroxyl groups on their benzene rings, how this difference affects adhesion and cohesion is not well understood. Herein, the chitosan backbone is functionalized with catechol and pyrogallol at similar modification rates (to give chitosan-catechol (CS-CA) and chitosan-pyrogallol (CS-GA), respectively) and their interaction energies are compared by using a surface forces apparatus (SFA). The phenolic moieties decrease the rigidity of the chitosan chain and increase solubility; consequently, CS-CA and CS-GA are more cohesive and adhesive than chitosan at pH 7.4. Moreover, the additional hydroxyl group of GA provides a further interacting chance; hence, CS-GA is more cohesive and adhesive than CS-CA. This study provides in-depth insight into interactions involving chitosan derivatives bearing introduced phenolic moieties that will help to develop biomedical adhesives.
Topics: Adhesiveness; Adhesives; Catechols; Chitosan; Gallic Acid; Hydrogen Bonding; Hydrogen-Ion Concentration; Pyrogallol; Solubility; Static Electricity; Thermodynamics
PubMed: 36457197
DOI: 10.1002/marc.202200845