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ACS Applied Materials & Interfaces Apr 2023Antibacterial hydrogel wound dressings with adhesive and antioxidant activity are desirable for treating skin injuries in clinical care. Hereby, a series of...
Antibacterial hydrogel wound dressings with adhesive and antioxidant activity are desirable for treating skin injuries in clinical care. Hereby, a series of multifunctional hydrogel wound dressings with high adhesive, self-healing, antioxidant, and antibacterial activity were designed and fabricated using dopamine (DA) and quercetin (QT). The multifunctional hydrogels were constructed by the interpenetrated quaternized chitosan chain segments and polyacrylamide network. The catechol groups on DA, QT, and the quaternary ammonium groups in the hydrogel system endow hydrogels with high strength, excellent adhesion, and self-healing ability. The results confirmed the admirable hemocompatibility and remarkable antibacterial activity of the multifunction hydrogels against and . Consequently, multifunction hydrogels with satisfactory adhesive and antibacterial activity are appropriate alternative materials in the fields of tissue adhesive and wound dressing applications.
Topics: Antioxidants; Adhesives; Hydrogels; Wound Healing; Chitosan; Anti-Bacterial Agents; Quercetin
PubMed: 36951622
DOI: 10.1021/acsami.3c01065 -
Journal of Biomaterials Science.... Mar 2020Bio-adhesives based on biopolymers have been widely researched for tissue repair. However, the adhesive properties are still insufficient to meet the practical...
Bio-adhesives based on biopolymers have been widely researched for tissue repair. However, the adhesive properties are still insufficient to meet the practical applications. Introducing functional groups into the polymer chains that have multi-interactions among inter/intra-molecules and with substrates is an efficient way to increase cohesion force and further improve the adhesive properties. In this study, 3,4-dihydroxyphenyl propionic acid (DPA) and dopamine (DA) containing adhesion functional catechol groups were employed to modify chitosan (CS) and γ-polyglutamic acid (γPGA), respectively. The substituted degrees of the catechol groups were controlled by the catechol compositions. DPA modified chitosan/DA modified γPGA (CS-DPA/γPGA-DA) adhesives prepared by mixing CS-DPA and γPGA-DA. Effects of the substituted degrees and substrates on the adhesion strength were measured by tensile testing machine. The results showed good adhesion property of the CS-DPA/γPGA-DA adhesive on many surfaces of the substrates. Especially on the arthrodial cartilage, the adhesive strength reached around 150 kPa, much higher than commercially available tissue adhesives. The high adhesion property might be due to the adhesion interactions between the catechol groups and substrates and the high cohesion forces induced by the crosslinking interactions formation among the catechol groups and the electrostatic interactions between the CS and γPGA polymers. experiments demonstrated that the adhesive had good biocompatibility. These results suggested the catechol-based adhesive is a very suitable and promising biomaterial in the clinical medicine field.
Topics: Adhesives; Animals; Biomimetic Materials; Bivalvia; Caffeic Acids; Catechols; Chitosan; Dopamine; Humans; Materials Testing; Polyglutamic Acid; Tissue Engineering
PubMed: 31815604
DOI: 10.1080/09205063.2019.1702276 -
ACS Applied Materials & Interfaces Feb 2019Underwater adhesives have drawn much attention in the areas of industrial and biomedical fields. However, it is still demanding to construct a tough underwater gel-based...
Underwater adhesives have drawn much attention in the areas of industrial and biomedical fields. However, it is still demanding to construct a tough underwater gel-based adhesive completely based on chemical constitution. Herein, a nonswellable and high-strength underwater adhesive gel is successfully fabricated through the random copolymerization of acrylic acid, butyl acrylate, and acrylated adenine in dimethyl sulfoxide (DMSO). The underwater adhesive behavior is skillfully regulated through hydrophobic aggregation induced by water-DMSO solvent exchange. The adhesive gels exhibit an excellent adhesive behavior for polytetrafluoroethylene, plastics, metals, rubber, and glasses in air and various aqueous solutions, including deionized water, seawater, and acid and alkali solutions (pH = 3 and 10, respectively). Moreover, the adhesive gels exhibited robust mechanical performance and remarkable nonswellable behavior, which were particularly important for applications of gel-based adhesives in water. It is anticipated that the strategy of bioinspired nucleobase-assisted underwater adhesive gel via hydrophobic aggregation induced by solvent exchange would provide an inspiration for the development of underwater adhesives.
Topics: Acrylates; Adenine; Adhesives; Dimethyl Sulfoxide; Gels; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Polymers; Rheology; Water
PubMed: 30666868
DOI: 10.1021/acsami.8b21686 -
Biomacromolecules Aug 2022Although adhesive hydrogels have been extensively explored, the development of adhesives with long-term strong adhesion capacity under various harsh environments is...
Although adhesive hydrogels have been extensively explored, the development of adhesives with long-term strong adhesion capacity under various harsh environments is still met with profound challenges such as sophisticated preparation, long-term curing, and low bonding strength. Herein, a series of robust adhesive hydrogels have been developed the polyphenol-epoxy-cross-linking (PEC) reactions between natural polyphenols (extracts) and epoxy glycidyl ethers. The as-prepared natural polyphenolic adhesive hydrogels could induce strong adhesion onto several kinds of typical substrates (i.e., wood, glass, paper, PET, PMMA, and Fe) under both dry and wet conditions based on multi-interactions. Moreover, those natural polyphenolic adhesives exhibited good low-temperature and solvent resistance performances, which could be widely used in different kinds of device repairment (i.e., chemical, petroleum, wood, metal, glass, plastic, rubber, and other industries) under different conditions. This work could provide new opportunities toward natural-inspired robust adhesives in various fields ranging from chemical transportation, industrial manufacturing, architectural design, and marine engineering to daily life.
Topics: Adhesives; Hydrogels; Tissue Adhesions; Tissue Adhesives; Wood
PubMed: 35861485
DOI: 10.1021/acs.biomac.2c00704 -
ACS Applied Materials & Interfaces Aug 2022Hydrogels are often used to fabricate strain sensors; however, they also suffer from freezing at low temperatures and become dry during long-time storage. Encapsulation...
Hydrogels are often used to fabricate strain sensors; however, they also suffer from freezing at low temperatures and become dry during long-time storage. Encapsulation of hydrogels with elastomers is one of the methods to solve these problems although the adhesion between hydrogels and elastomers is usually low. In this work, using bovine serum protein (BSA) as the natural globulin model and glycerol/HO as the mixture solvent, BSA/polyacrylamide organohydrogels (BSA/PAAm OHGs) were prepared by a facile photopolymerization approach. At the optimal condition, BSA/PAAm OHG demonstrated not only high toughness but also tough adhesion properties, which could strongly adhere to various substrates, such as glass, metals, rigid polymeric materials (even poly(tetrafluoroethylene), i.e., PTFE), and soft elastomers. Moreover, BSA/PAAm OHG was flexible and showed tough adhesion at -20 °C. The toughening mechanism and the adhesive mechanism were proposed. On being encapsulated by poly(dimethylsiloxane) (PDMS), it illustrated good antidrying performance. After introducing a conductive filler, the encapsulated BSA/PAAm OHG could be used as a strain sensor to detect human motions. This work provides a better understanding of the adhesive mechanism of natural protein-based organohydrogels.
Topics: Adhesives; Elastomers; Electric Conductivity; Globulins; Humans; Hydrogels
PubMed: 35972900
DOI: 10.1021/acsami.2c07213 -
Colloids and Surfaces. B, Biointerfaces Apr 2022Biologically inspired adhesives microstructure requires enough flexibility to make a conformal attachment to the surface as well as high rigidity to maintain the...
Biologically inspired adhesives microstructure requires enough flexibility to make a conformal attachment to the surface as well as high rigidity to maintain the mechanical stability of structure against buckling. To tackle these conflicting factors for the synthetic adhesives is a challenge towards large-scale production and utilizing in practical applications. Addressing this problem, we have fabricated a honeycomb structure with a soft elastic film, partially covering the cavity of the honeycomb pattern. Honeycomb structure provides enough support to maintain the structural stability of the microstructure and soft PDMS film over the pattern provides sufficient flexibility to form a strong attachment with the target surface. Meanwhile, the resemblance of the designed structure to the octopi's sucker generates a negative pressure resulting in suction forces. To justify this suction effect, we compared our results with other controlled honeycomb microstructures (1) without any elastic film (2) with elastic film covering the whole cavity of the honeycomb pattern. Experimental results and theoretical prediction demonstrate the synergistic role of van der Waals and suction forces in the proposed partial-film honeycomb microstructure. The synergistic role of adhesive forces makes this structure a stronger, durable, and surface adaptable adhesive. We also investigated the critical role of the viscous forces for our proposed microstructure in water and silicon oil wetting conditions which signify the contribution of capillary forces.
Topics: Adhesives; Water; Wettability
PubMed: 35078054
DOI: 10.1016/j.colsurfb.2022.112335 -
ACS Nano Dec 2021Dry adhesives that combine strong adhesion, high transparency, and reusability are needed to support developments in emerging fields such as medical electrodes and the...
Dry adhesives that combine strong adhesion, high transparency, and reusability are needed to support developments in emerging fields such as medical electrodes and the bonding of electronic optical devices. However, achieving all of these features in a single material remains challenging. Herein, we propose a pressure-responsive polyurethane (PU) adhesive inspired by the octopus sucker. This adhesive not only showcases reversible adhesion to both solid materials and biological tissues but also exhibits robust stability and high transparency (>90%). As the adhesive strength of the PU adhesive corresponds to the application force, adhesion could be adjusted by the preloading force and/or pressure. The adhesive exhibits high static adhesion (∼120 kPa) and 180° peeling force (∼500 N/m), which is far stronger than those of most existing artificial dry adhesives. Moreover, the adhesion strength is effectively maintained even after 100 bonding-peeling cycles. Because the adhesive tape relies on the combination of negative pressure and intermolecular forces, it overcomes the underlying problems caused by glue residue like that left by traditional glue tapes after removal. In addition, the PU adhesive also shows wet-cleaning performance; the contaminated tape can recover 90-95% of the lost adhesion strength after being cleaned with water. The results show that an adhesive with a microstructure designed to increase the contribution of negative pressure can combine high reversible adhesion and long fatigue life.
Topics: Adhesiveness; Adhesives; Biomimetic Materials; Biomimetics; Water
PubMed: 34797635
DOI: 10.1021/acsnano.1c03882 -
Molecules (Basel, Switzerland) Dec 2022This study has reviewed the naturally occurring bioadhesives produced in marine and freshwater aqueous environments and in the mucinous exudates of some terrestrial... (Review)
Review
This study has reviewed the naturally occurring bioadhesives produced in marine and freshwater aqueous environments and in the mucinous exudates of some terrestrial animals which have remarkable properties providing adhesion under difficult environmental conditions. These bioadhesives have inspired the development of medical bioadhesives with impressive properties that provide an effective alternative to suturing surgical wounds improving closure and healing of wounds in technically demanding tissues such as the heart, lung and soft tissues like the brain and intestinal mucosa. The Gecko has developed a dry-adhesive system of exceptional performance and has inspired the development of new generation re-usable tapes applicable to many medical procedures. The silk of spider webs has been equally inspiring to structural engineers and materials scientists and has revealed innovative properties which have led to new generation technologies in photonics, phononics and micro-electronics in the development of wearable biosensors. Man made products designed to emulate the performance of these natural bioadhesive molecules are improving wound closure and healing of problematic lesions such as diabetic foot ulcers which are notoriously painful and have also found application in many other areas in biomedicine. Armed with information on the mechanistic properties of these impressive biomolecules major advances are expected in biomedicine, micro-electronics, photonics, materials science, artificial intelligence and robotics technology.
Topics: Animals; Artificial Intelligence; Adhesives; Bivalvia; Silk; Tissue Adhesives
PubMed: 36558114
DOI: 10.3390/molecules27248982 -
The Journal of Experimental Biology Aug 2018Underwater adhesive secretions are a promising source of inspiration for biomedical and industrial applications. Although marine permanent adhesives have been... (Review)
Review
Underwater adhesive secretions are a promising source of inspiration for biomedical and industrial applications. Although marine permanent adhesives have been extensively investigated, reversible adhesion, e.g. as used for locomotion and feeding, is still poorly understood. Here, we summarise the current knowledge on secretion-based, temporary adhesive systems in aquatic environments, with a special emphasis on the morphology and structure of adhesive organs and adhesive material. Many animals employing temporary adhesion to the substratum rely on so-called duo-gland adhesive organs, consisting of two secretory gland cells and one supportive cell. We give a detailed depiction of a basic duo-gland adhesive organ and variations thereof. Additionally, we discuss temporary adhesive systems with an alternative building plan. Next, the topography of secreted adhesive footprints is described based on examples. The limited data on the composition of temporary adhesives are summarised, separating known protein components and carbohydrate residues. There are still large gaps in our understanding of temporary adhesion. We discuss three proposed models for detachment, although the actual mechanism of voluntary detachment is still a matter for debate.
Topics: Adhesiveness; Adhesives; Animals; Aquatic Organisms; Behavior, Animal; Bodily Secretions
PubMed: 30166319
DOI: 10.1242/jeb.182717 -
Acta Biomaterialia Sep 2022Tough hydrogel adhesives that consist of a robust gel network and can strongly adhere to wet tissues have shown great promise as the next generation of bioadhesives....
Tough hydrogel adhesives that consist of a robust gel network and can strongly adhere to wet tissues have shown great promise as the next generation of bioadhesives. While a variety of chemistries can be utilized to construct the tough gel network, the covalent conjugation methods for tissue adhesion are still limited. Here we report, for the first time, the use of side product-free amine-thiolactone chemistry which initiates a double crosslinking adhesion mechanism to develop tough gel adhesives. Thiolactone groups can conjugate with tissue-surface amines via a ring-opening reaction. The resultant thiol end groups can be further crosslinked into disulfide linkages, enabling the formation of a robust and stable adhesion layer. The thiolactone-bearing tough hydrogel composed of methacrylate-modified gelatin, acrylic acid, and thiolacone acrylamide exhibited good biocompatibility and mechanical properties, and strong adhesion to various types of engineering solids and tissues. We also demonstrated its ability to function as a tissue sealant and drug depot. The novel adhesion mechanism will diversify future design of bioadhesives for hemostasis, drug delivery, tissue repair, and other applications. STATEMENT OF SIGNIFICANCE: Tough hydrogel adhesives with excellent tissue-adhesive and mechanical properties have demonstrated tremendous promise for hemostasis, tissue repair, and drug delivery applications. However, the covalent chemistry for tissue adhesion has been limited, which narrows the choice of materials for the design of bioadhesives and may pose a safety concern. Here, for the first time, we report the use of side product-free amine-thiolactone chemistry, which involves a double crosslinking adhesion mechanism, for developing tough hydrogel adhesives. We demonstrate that thiolactone-bearing tough hydrogels exhibit favorable biocompatibility and mechanical properties, and superior adhesion to both engineering solids and tissues. Our new adhesion technology will greatly facilitate future development of advanced bioadhesives for numerous biomedical applications.
Topics: Adhesives; Amines; Gelatin; Humans; Hydrogels; Tissue Adhesions; Tissue Adhesives
PubMed: 35870776
DOI: 10.1016/j.actbio.2022.07.028