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Journal of Medical Cases Feb 2021is a rare organism infrequently isolated from cultures. Mostly known to cause urinary tract infection, it can cause bacteremia leading to severe urosepsis and infective...
is a rare organism infrequently isolated from cultures. Mostly known to cause urinary tract infection, it can cause bacteremia leading to severe urosepsis and infective endocarditis. Embolization is frequently reported with endocarditis (AUE); hence, the presentation is highly variable. Sequelae such as various central nervous system manifestations, sepsis, valvular regurgitation with heart failure and even coronary artery involvement have been reported. We report a case of a 58-year-old man with AUE of the aortic valve, severe aortic regurgitation and embolic stroke as a result of embolization from AUE and ultimately required aortic valve replacement. Our case highlights this rare cause of endocarditis and offers insight into the variability of patient presentation and risk factors to consider.
PubMed: 34434432
DOI: 10.14740/jmc3612 -
The Canadian Journal of Neurological... Sep 2020
Topics: Aerococcus; Endocarditis; Gram-Positive Bacterial Infections; Humans; Infarction
PubMed: 32329421
DOI: 10.1017/cjn.2020.80 -
Journal of the Pediatric Infectious... Nov 2019Aerococcus urinae has been found to cause urinary tract infection in elderly patients and has been reported as a rare cause of infective endocarditis associated with... (Review)
Review
Aerococcus urinae has been found to cause urinary tract infection in elderly patients and has been reported as a rare cause of infective endocarditis associated with significant morbidity and death in adults. However, information regarding its occurrence in children is lacking. We report here the case of a pediatric patient with subacute A urinae infective endocarditis with mycotic aneurysms.
Topics: Aerococcus; Aneurysm, Infected; Anti-Bacterial Agents; Child; Computed Tomography Angiography; Endocarditis, Subacute Bacterial; Gram-Positive Bacterial Infections; Humans; Male; Penicillin G; Pulmonary Artery; Thoracotomy; Treatment Outcome
PubMed: 30892601
DOI: 10.1093/jpids/piz016 -
Journal of Clinical Microbiology Jul 2021Aerococcus urinae is a urinary pathogen with well-described resistance to fluoroquinolones. This study aimed to validate the gradient diffusion (GD) method (Etest) on...
Aerococcus urinae is a urinary pathogen with well-described resistance to fluoroquinolones. This study aimed to validate the gradient diffusion (GD) method (Etest) on cation-adjusted Mueller-Hinton agar with 5% sheep blood for testing the susceptibilities of Aerococcus urinae to the antimicrobial agents ciprofloxacin and levofloxacin and to compare the Etest to the broth microdilution (BMD) method from CLSI document M45-A3. Agar dilution (AD), as recommended by EUCAST, was used as an alternative reference method to arbitrate discrepancies or address technical issues. Aerococcus urinae isolates from urinary specimens were prospectively collected between June 2016 and December 2017 from six hospitals in Quebec, Canada, and identifications were confirmed using Vitek MS with the IVD 3.0 database. Of the 207 isolates tested using BMD, 37 (17.9%) showed trailing and 19 (9.2%) showed insufficient growth; these were tested using AD. Also, 38 isolates (18.4%) for ciprofloxacin and 13 isolates (6.3%) for levofloxacin showed a lack of essential or categorical agreement between the Etest and BMD and were also tested by AD. By use of a combined reference method (BMD or AD), the susceptibility rates of Aerococcus urinae were 82.6% and 81.6% for ciprofloxacin and levofloxacin, respectively. Categorical agreement between GD and the combined reference methods was 95.2% for ciprofloxacin and 97.1% for levofloxacin, with no very major error identified. Major and minor error rates were 0.6% and 4.3% for ciprofloxacin and 1.2% and 1.9% for levofloxacin. Overall, antimicrobial susceptibility testing (AST) using the Etest on sheep blood agar showed good agreement with the reference methods and can be considered by clinical laboratories wishing to perform AST on Aerococcus urinae isolates.
Topics: Aerococcus; Animals; Anti-Bacterial Agents; Canada; Disk Diffusion Antimicrobial Tests; Fluoroquinolones; Microbial Sensitivity Tests; Quebec; Sheep
PubMed: 34076476
DOI: 10.1128/JCM.00259-21 -
IDCases 2023is a Gram-positive, catalase-negative coccus, rarely responsible for urinary tract infections and seldom described for musculoskeletal infections like spondylodiscitis....
is a Gram-positive, catalase-negative coccus, rarely responsible for urinary tract infections and seldom described for musculoskeletal infections like spondylodiscitis. An 86-year-old man presented to our hospital for groin pain without fever. Pelvic CT-guided biopsy revealed an pubic symphysis osteomyelitis. He received a treatment by amoxicillin for six weeks, and did not need any surgery. An eight -month- follow-up showed a favorable evolution. Pubic symphysis infection can be induced by a wide variety of pathogens, and may have very different clinical presentations. Some authors recommend systematic surgery, but in case of susceptible pathogen associated with a low level of joint destruction, medical treatment alone should be sufficient to cure and make surgery unnecessary.
PubMed: 37928817
DOI: 10.1016/j.idcr.2023.e01911 -
Acta Clinica Belgica Dec 2018New methods of microbiology identification as MALDI-TOF MS increased the rate of Aerococci detection in microbiological samples making this germ an emerging pathogen....
OBJECTIVE AND IMPORTANCE
New methods of microbiology identification as MALDI-TOF MS increased the rate of Aerococci detection in microbiological samples making this germ an emerging pathogen. The purpose of this case report and literature review is to highlight the role of A. urinae in spine infection and discuss the management of this type of infection.
CLINICAL PRESENTATION AND INTERVENTION
A 32-year-old man, with a medical history of paraplegia secondary to a relapsing form of multiple sclerosis, was admitted because of lower back-pain following complaints suggestive of urinary tract infection. Spondilodiscitis was diagnosed and Aerococcus urinae was identified from bone culture. The patient improved after surgery and appropriate antibiotherapy.
CONCLUSION
A. urinae is currently more frequently identified since the introduction of MALDI-TOF MS in routine laboratories. Serious infections as endocarditis, bacteremia and spondylodiscitis have been reported usually in patients with predisposing conditions. This pathogen can be successfully treated with β-lactam antibiotics which can be replaced by vancomycin in case of penicillin allergy.
Topics: Adult; Aerococcus; Anti-Bacterial Agents; Discitis; Gram-Positive Bacterial Infections; Humans; Male; Tomography, X-Ray Computed
PubMed: 29498325
DOI: 10.1080/17843286.2018.1443003 -
IDCases 2020Infective endocarditis (IE) caused by is rare. The true incidence rate of this pathogen is likely underestimated as this is easily misidentified as or . It is also...
Infective endocarditis (IE) caused by is rare. The true incidence rate of this pathogen is likely underestimated as this is easily misidentified as or . It is also associated with increased risk of complications such as systemic emboli. usually affects elderly males with underlying urological conditions. Here we present a case of IE with this rare in a young man with a bioprosthetic aortic valve, despite negative urine cultures.
PubMed: 32884902
DOI: 10.1016/j.idcr.2020.e00912 -
Infection Apr 2016To define the clinical presentation of aerococcal infective endocarditis (IE) and the prevalence of synergy between penicillin and gentamicin on aerococcal isolates.
PURPOSE
To define the clinical presentation of aerococcal infective endocarditis (IE) and the prevalence of synergy between penicillin and gentamicin on aerococcal isolates.
METHODS
Cases of aerococcal IE between 2002 and 2014 were identified in the Swedish Registry of Infective Endocarditis (SRIE). MALDI-TOF MS was used to confirm species determination. The medical records were analysed and compared to cases reported to the SRIE caused by other pathogens.
RESULTS
Sixteen cases of aerococcal IE, fourteen with Aerococcus urinae and two with Aerococcus sanguinicola, were confirmed. Etest-based methods and time-kill experiments suggested synergy between penicillin and gentamicin towards seven of fifteen isolates. The patients with aerococcal IE were significantly older than those with streptococci or Staphylococcus aureus IE. Most of the patients had underlying urinary tract diseases or symptoms suggesting a urinary tract focus of the infection. Seven patients with aerococcal IE presented with severe sepsis but ICU treatment was needed only in one patient and there was no fatality. Valve exchange surgery was needed in four patients and embolization was seen in three patients.
CONCLUSIONS
This report is the largest on aerococcal IE and suggests that the prognosis is relatively favourable despite the fact that the patients are old and have significant comorbidities.
Topics: Aerococcus; Aged; Aged, 80 and over; Anti-Bacterial Agents; Disk Diffusion Antimicrobial Tests; Drug Synergism; Endocarditis; Female; Gentamicins; Gram-Positive Bacterial Infections; Humans; Male; Middle Aged; Penicillins; Prognosis; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sweden
PubMed: 26119199
DOI: 10.1007/s15010-015-0812-8 -
Cureus Jun 2022is a rare cause of urinary tract infection (UTI) seen in elderly males with multimorbidity. Incidence is estimated between 0.15 and 0.8%. This organism is frequently...
is a rare cause of urinary tract infection (UTI) seen in elderly males with multimorbidity. Incidence is estimated between 0.15 and 0.8%. This organism is frequently misidentified for other gram-positive species. Missed or delayed diagnosis of UTI can lead to systemic infection with high morbidity and potential mortality. We present a classic case of UTI in a 91-year-old male with multiple comorbidities, including heart failure, diabetes mellitus, and metastatic prostate carcinoma. Empiric therapy with nitrofurantoin was unsuccessful, but intravenous ceftriaxone and bladder catheterization resulted in rapid symptomatic improvement. Variable antimicrobial sensitivities and resistance have been reported for . Therefore, antimicrobial resistance testing should be performed for all patients with infections.
PubMed: 35911344
DOI: 10.7759/cureus.26379 -
BMJ Case Reports Sep 2023An elderly male with an extensive medical history was admitted for sepsis of unspecified origin; the source was later found to be an urinary tract infection. Urinalysis...
An elderly male with an extensive medical history was admitted for sepsis of unspecified origin; the source was later found to be an urinary tract infection. Urinalysis and conventional urine culture were used in diagnosing this infection, and it was successfully treated with a 7-day course of intravenous ceftriaxone. The patient had no recurrence of urinary symptoms or development of complications at his follow-up. While has traditionally been described as an uncommon and relatively avirulent source of urinary tract infections, increasing reports of positive isolation suggest its incidence may be higher than previously believed. Cases have been more frequently reported among elderly males with multimorbidity and repeat hospitalisation. A lower threshold of suspicion for urinary tract infections in this population may better guide empiric therapy and help avoid potentially life-threatening complications.
Topics: Aged; Humans; Male; Urinary Tract Infections; Aerococcus; Ceftriaxone; Administration, Intravenous
PubMed: 37730420
DOI: 10.1136/bcr-2023-257496