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American Journal of Hematology Oct 2022
Topics: Castleman Disease; Edema; Humans; Inflammation; Leukopenia; Thrombocytopenia
PubMed: 35794839
DOI: 10.1002/ajh.26651 -
Journal of the American Dental... May 2022
Topics: Diagnosis, Differential; Edema; Humans; Lip
PubMed: 34001328
DOI: 10.1016/j.adaj.2021.03.001 -
Radiologie (Heidelberg, Germany) Apr 2023Bone stress injuries is an umbrella term that encompasses repetitive microtraumatic events that accumulate to surpass the threshold of bone failure, which can range from... (Review)
Review
Bone stress injuries is an umbrella term that encompasses repetitive microtraumatic events that accumulate to surpass the threshold of bone failure, which can range from bone marrow edema to frank stress fracture as the end point. Due to nonspecific clinical complaints and physical findings, imaging plays a central role in the diagnostic workup of these entities. Magnetic resonance imaging (MRI) is the most important imaging modality with a high sensitivity and specificity and allows for differential diagnosis of other diseases. Edema-sensitive with fat suppression and T1-weighted sequences are the core sequence types, and contrast-enhanced imaging-albeit displaying subtle fractures much more easily-is rarely necessary. Furthermore, MRI enables differentiation of injury severity, which has an impact on length of rehabilitation, therapeutic regimen, and the time to return to sports in athletes.
Topics: Humans; Fractures, Stress; Magnetic Resonance Imaging; Bone Marrow Diseases; Athletic Injuries; Edema
PubMed: 36882548
DOI: 10.1007/s00117-023-01129-4 -
American Family Physician Aug 2023
Topics: Humans; Lip; Edema
PubMed: 37590866
DOI: No ID Found -
Hematological Oncology Aug 2023Thrombocytopenia, anasarca, fever, reticulin fibrosis/renal failure, and organomegaly (TAFRO) syndrome is rare in clinical practice. It is a systemic inflammatory... (Review)
Review
Thrombocytopenia, anasarca, fever, reticulin fibrosis/renal failure, and organomegaly (TAFRO) syndrome is rare in clinical practice. It is a systemic inflammatory disease caused by a cytokine storm. Its clinical manifestations include thrombocytopenia, systemic edema, fever, bone marrow fibrosis, renal insufficiency, and organ enlargement. The high mortality rate of TAFRO syndrome is due to the difficulty of acquiring biopsy samples for diagnosis and the rapid disease progression. This disease is poorly understood by clinicians. Early detection, accurate diagnosis, and timely treatment play key roles in prolonging the survival of the patients. This review summarizes the latest progress in the pathogenesis, diagnostic criteria, and treatment regimens of TAFRO syndrome, aiming to help clinicians better understand TAFRO syndrome and improve its diagnosis and treatment.
Topics: Humans; Castleman Disease; Renal Insufficiency; Primary Myelofibrosis; Edema; Anemia; Thrombocytopenia
PubMed: 36148768
DOI: 10.1002/hon.3075 -
British Journal of Community Nursing Oct 2017
Topics: Community Health Nursing; Edema; Fluoroscopy; Humans; State Medicine; United Kingdom
PubMed: 28961049
DOI: 10.12968/bjcn.2017.22.Sup10.S5 -
Radiologie (Heidelberg, Germany) Apr 2023Groin pain in athletes can have various causes. Radiologically, osteitis pubis and clefts with affection of the interpubic disc as well as muscle and tendon tears near... (Review)
Review
CLINICAL/METHODICAL ISSUE
Groin pain in athletes can have various causes. Radiologically, osteitis pubis and clefts with affection of the interpubic disc as well as muscle and tendon tears near the pubic bone can be clearly identified.
STANDARD RADIOLOGICAL METHODS
Magnetic resonance imaging (MRI) is the imaging modality of choice, as well as single-leg stand imaging (flamingo view radiographs), and where appropriate symphysography.
METHODICAL INNOVATIONS
Optimized MRI sequence protocol with oblique (axial oblique) slices parallel to the linea arcuata of the iliac bone is recommended. High-resolution MRI sequences and symphysography can detect superior and secondary cleft formation. Instabilities of the pubic symphysis can be diagnosed using flamingo view radiographs.
PERFORMANCE
The MRI findings of osteitis pubis and clinical symptoms correlate. The presence of parasymphyseal bone marrow edema is the earliest morphological sign of acute osteitis pubis on MR imaging. Edema in the periosteal tissue and isolated muscle lesions next to the symphysis are generally associated with more severe clinical symptoms.
ACHIEVEMENTS AND PRACTICAL RECOMMENDATIONS
Close communication between radiologists and the referring physicians is indispensable when planning an adequate imaging protocol, and precise knowledge of the clinical symptoms in the case of clinical suspicion of osteitis pubis allows for a reliable diagnosis and provides important prognostic information.
Topics: Humans; Groin; Osteitis; Pelvic Pain; Athletes; Edema
PubMed: 36715718
DOI: 10.1007/s00117-023-01117-8 -
Autoimmunity Reviews Aug 2022Sjögren's syndrome (SjS) is a systemic autoimmune disease characterized by lymphocytic infiltration of the salivary and lacrimal glands associated with sicca syndrome.... (Review)
Review
BACKGROUND
Sjögren's syndrome (SjS) is a systemic autoimmune disease characterized by lymphocytic infiltration of the salivary and lacrimal glands associated with sicca syndrome. TAFRO syndrome is a systemic inflammatory disease of unknown cause, characterized by Thrombocytopenia, Anasarca, Fever, Reticulin fibrosis, Renal dysfunction and Organomegaly, first reported in 2010 in Japanese patients. Despite their rarity, both conditions have been concurrently reported in several patients during the recent years, hence questioning the existence of shared or related features.
METHODS
A systematic review of the literature regarding SjS associated with TAFRO syndrome (SjS-TAFRO) was performed. The 2019 updated Masaki diagnostic criteria were used for TAFRO syndrome and SjS was considered when the diagnosis was mentioned by the authors, necessarily with either anti-Sjogren's Syndrome A (SSA) ± anti-Sjogren's Syndrome B (SSB) antibodies and/or histological evidence of focal lymphocytic sialadenitis.
RESULTS
Ten cases of SjS-TAFRO have been reported in the literature to date. Compared to SjS patients without TAFRO syndrome, these 10 SjS-TAFRO had a lower female predominance (2.3:1 vs 9:1 women to man ratio) and a higher frequency of anti-SSA antibodies (90% vs 70%). All fulfilled the three major Masaki criteria i.e., anasarca, thrombocytopenia, and systemic inflammation. Seven of them (70%) had megakaryocyte hyperplasia or reticulin fibrosis in the bone marrow. Lymph node biopsy was performed in 8 out of 10 cases (80%) and results were consistent with Castleman disease in 6 (75%). Eight of them had developed renal failure (80%) within six months. Nine of them (90%) had organomegaly, with hepatosplenomegaly in 8 cases and splenomegaly alone in 1.
CONCLUSION
This review brings new insights regarding TAFRO syndrome and suggests it could be a severe manifestation of SjS. The identification of shared abnormal signaling pathways could help in the therapeutic management of both diseases, which face an unmet therapeutic need.
Topics: Antibodies, Antinuclear; Castleman Disease; Edema; Female; Fibrosis; Humans; Male; Reticulin; Sjogren's Syndrome; Thrombocytopenia
PubMed: 35803499
DOI: 10.1016/j.autrev.2022.103137 -
British Journal of Community Nursing Apr 2020
Topics: Behavior Therapy; Chronic Disease; Edema; Humans; Lipedema; Practice Guidelines as Topic
PubMed: 32271102
DOI: 10.12968/bjcn.2020.25.Sup4.S5 -
Critical Reviews in Oncology/hematology Aug 2018TAFRO is an acrostic and includes thrombocytopenia (T), anasarca (A), fever (F), reticulin fibrosis (R) and organomegaly (O) (Takai et al., 2013). TAFRO syndrome has... (Review)
Review
TAFRO is an acrostic and includes thrombocytopenia (T), anasarca (A), fever (F), reticulin fibrosis (R) and organomegaly (O) (Takai et al., 2013). TAFRO syndrome has been described firstly by Takai in Japanese patients. However TAFRO cases have been reported from US, Europe and other countries (Takai et al., 2010; Iwaki et al., 2016; Abdo et al., 2014). Three major and at least one minor criteria and exclusion of infectious, rheumatologic and neoplastic diseases are required for the diagnosis of TAFRO. In fact TAFRO must be thought in clinically undiagnosed and unsolved problemmatic cases.
Topics: Castleman Disease; Edema; Fever; Humans; Pathologists; Syndrome; Thrombocytopenia
PubMed: 29958635
DOI: 10.1016/j.critrevonc.2018.05.015