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Heart (British Cardiac Society) Jul 2020Aortic stenosis (AS) is a common valve disorder in an ageing population in western countries, and women, with longer life expectancy, comprise a substantial percentage... (Review)
Review
Aortic stenosis (AS) is a common valve disorder in an ageing population in western countries, and women, with longer life expectancy, comprise a substantial percentage of elderly patients with AS. Compared with men, women exhibit distinctive characteristics at the level of stenotic valve leaflets and subsequent compensatory responses of the left ventricle to chronic pressure overload, and in clinical presentation, consequences and response to intervention. Randomised controlled trials of transcatheter aortic valve implantation have yielded new evidence of sex differences in both short-term and long-term outcomes after intervention. A comprehensive knowledge of the existing evidence may inform our understanding of gender differences during assessment and treatment of patients with AS. In this paper, we review the available evidence regarding sex differences in AS in terms of symptoms, clinical presentation, anatomical differences and pathophysiological progression, management and outcomes after aortic valve replacement. Implications for further research are suggested.
Topics: Aged; Aged, 80 and over; Aortic Valve; Aortic Valve Stenosis; Female; Health Status Disparities; Healthcare Disparities; Hemodynamics; Humans; Male; Middle Aged; Prognosis; Risk Assessment; Risk Factors; Sex Factors; Transcatheter Aortic Valve Replacement; Ventricular Function, Left; Ventricular Remodeling; Women's Health
PubMed: 32201373
DOI: 10.1136/heartjnl-2019-315407 -
JAMA Cardiology Aug 2016
Topics: Aortic Valve Stenosis; Humans; Transcatheter Aortic Valve Replacement
PubMed: 27434020
DOI: 10.1001/jamacardio.2016.2060 -
Heart (British Cardiac Society) Sep 2021
Topics: Aortic Valve; Aortic Valve Disease; Aortic Valve Stenosis; Humans
PubMed: 34127542
DOI: 10.1136/heartjnl-2021-319560 -
Journal of Interventional Cardiology Jun 2018Degenerative aortic valve stenosis is the most common valvular heart disease seen in developed countries. Since the implementation of transcatheter aortic valve... (Review)
Review
Degenerative aortic valve stenosis is the most common valvular heart disease seen in developed countries. Since the implementation of transcatheter aortic valve replacement, there has been a surge of efforts to improve procedural technique as well as reduce mortality. Until recently, the mainstay method of assessment of valve implantation as well as paravalvular regurgitation has relied heavily on imaging techniques including transesophageal echocardiography and aortic root angiography. There has been a lot of scientific inquiry to identify biomarkers in the management of patients with aortic stenosis. von Willebrand factor activity and high molecular weight multimer level assessment has emerged as an excellent biomarker with intraoperative, point of care potential. These implications can both supplement imaging modalities as well as potentially serve as a more accurate assessment TAVR complications.
Topics: Aged, 80 and over; Aortic Valve Stenosis; Biomarkers; Echocardiography, Transesophageal; Female; Heart Valve Prosthesis; Heart Valve Prosthesis Implantation; Humans; Male; Transcatheter Aortic Valve Replacement; von Willebrand Factor
PubMed: 29285810
DOI: 10.1111/joic.12478 -
JACC. Cardiovascular Imaging Feb 2020
Topics: Aortic Valve Stenosis; Fibrosis; Humans; Myocardium
PubMed: 31326482
DOI: 10.1016/j.jcmg.2019.05.021 -
Clinical Radiology Jan 2021
Topics: Aortic Valve; Aortic Valve Stenosis; Humans; Transcatheter Aortic Valve Replacement
PubMed: 33036780
DOI: 10.1016/j.crad.2020.08.037 -
Heart (British Cardiac Society) Oct 2022
Topics: Humans; Aortic Valve Stenosis; Aortic Valve; Disease Progression
PubMed: 35738896
DOI: 10.1136/heartjnl-2022-321331 -
Heart (British Cardiac Society) Jun 2020
Topics: Aortic Valve; Aortic Valve Stenosis; Heart Valve Prosthesis; Humans
PubMed: 32144187
DOI: 10.1136/heartjnl-2019-316436 -
Vnitrni Lekarstvi 2021Cardiac damage in severe aortic stenosis (AS) is not limited to the aortic valve and left ventricle, but is a systemic disease characterized by a significant alteration...
Cardiac damage in severe aortic stenosis (AS) is not limited to the aortic valve and left ventricle, but is a systemic disease characterized by a significant alteration in cardiac structure and function. Therefore, a new classification of AS based on the degree of myocardial damage was proposed. A significant number of patients with AS have right ventricular dysfunction likely due to ventricular interdependence. Relationship between right ventricular dysfunction and increased mortality in both symptomatic and asymptomatic patients with severe AS was demonstrated. These patients could benefit more from intervention. Therefore, a standardized echocardiographic examination of a patients with severe aortic stenosis should provide a detailed analysis of right ventricular function.
Topics: Aortic Valve; Aortic Valve Stenosis; Echocardiography; Heart Valve Prosthesis Implantation; Heart Ventricles; Humans; Treatment Outcome; Ventricular Dysfunction, Left; Ventricular Dysfunction, Right; Ventricular Function, Left
PubMed: 34275314
DOI: No ID Found -
Journal of the American College of... Jun 2021
Topics: Aortic Valve Stenosis; Humans; Stroke Volume
PubMed: 34082910
DOI: 10.1016/j.jacc.2021.04.027