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Acta Dermato-venereologica Mar 2019
Review
Topics: Adult; Anetoderma; Humans; Lupus Erythematosus, Systemic; Male
PubMed: 30521059
DOI: 10.2340/00015555-3100 -
Clinical Journal of Gastroenterology Feb 2015Wilson's disease is an autosomal recessive disorder of copper homeostasis with predominantly hepatic and neuropsychiatric involvement. Anetoderma is a rare benign...
BACKGROUND
Wilson's disease is an autosomal recessive disorder of copper homeostasis with predominantly hepatic and neuropsychiatric involvement. Anetoderma is a rare benign condition with focal damage of dermal elastic tissue. Previous reports described this skin disorder in association with prolonged D-Penicillamine therapy.
CASE PRESENTATION
A 26-year-old male was referred for evaluation of asymptomatic elevation of aminotransferase levels. Investigations showed negative markers for chronic viral and autoimmune hepatitis, low ceruloplasmin level, and increased copper urinary excretion. Liver biopsy revealed chronic hepatitis with moderate activity and severe bridging fibrosis. Mutation analysis found a compound heterozygote genotype and supported a diagnosis of Wilson's disease. At the time of the primary physical exam, skin lesions were also observed, consisting of numerous white to pale papules less than 7-8 mm in diameter with central protrusion located at the upper part of the body. Primary anetoderma was established based on presentation and skin biopsy findings. Therapy with D-Penicillamine at a daily dose of 1500 mg was started, and, during 12-month follow-up, aminotransferase decreased to normal and skin lesions remained unchanged.
CONCLUSION
In our opinion the case is a first reported association between Wilson's disease and primary anetoderma. The possible mechanism behind this relationship is discussed.
Topics: Adult; Anetoderma; Hepatolenticular Degeneration; Humans; Male
PubMed: 25617204
DOI: 10.1007/s12328-015-0550-6 -
Indian Journal of Dermatology,... 2021
Topics: Adult; Anetoderma; Humans; Male
PubMed: 32415048
DOI: 10.4103/ijdvl.IJDVL_257_19 -
Dermatology Online Journal Dec 2017Anetoderma is a rare benign elastolytic disorder that is characterized by focal loss of elastin fibers on histopathology and is often recalcitrant to treatment. We...
Anetoderma is a rare benign elastolytic disorder that is characterized by focal loss of elastin fibers on histopathology and is often recalcitrant to treatment. We present a case of a patient with a 20-year history of pruritic and painful hyperpigmented atrophic papules clustered on the neck, axillae, inframammary folds, and right medial thigh. Although the histopathologyof her axillary lesions was consistent with anetoderma, her clinical presentation is unusual given the extent of involvement, reported pain and pruritus, and sharp demarcation of the distribution. The diagnosticuncertainty of this case led to added difficulty in management of a disease that is already notoriously difficult to treat and may significantly impact patient's quality of life.
Topics: Anetoderma; Delayed Diagnosis; Female; Humans; Middle Aged; Undifferentiated Connective Tissue Diseases
PubMed: 29447658
DOI: No ID Found -
Giornale Italiano Di Dermatologia E... Oct 2020
Topics: Adult; Anetoderma; Humans; Impetigo; Male; Pityriasis Rosea
PubMed: 30229641
DOI: 10.23736/S0392-0488.18.06115-1 -
Open Access Macedonian Journal of... Sep 2019Anetodermas are rare disorders of connective tissue with a focal loss of elastic fibres in the upper and mid dermis. Two types are separated, inflammatory and...
BACKGROUND
Anetodermas are rare disorders of connective tissue with a focal loss of elastic fibres in the upper and mid dermis. Two types are separated, inflammatory and non-inflammatory.
CASE REPORTS
We report two cases of acquired anetoderma Schweniger-Buzzi type. This non-inflammatory subtype is characterised by skin-coloured or whitish atrophic sac-like protrusions of trunk skin in adult males. Chronic infections and autoimmune disorders have been excluded. The diagnosis had been confirmed by characteristic histopathology.
CONCLUSIONS
Anetodermas are symptomless disorders. They can be easily overlooked. The knowledge of such conditions is of importance to identify patients with a risk of thromboembolic events and underlying infections or autoimmune connective tissue diseases.
PubMed: 31850130
DOI: 10.3889/oamjms.2019.560 -
Acta Dermatovenerologica Croatica : ADC Aug 2020Iatrogenic anetoderma of prematurity (IAOP) represents a benign iatrogenic dermatosis characterized by focal, well-demarcated areas of atrophic skin in preterm infants.... (Review)
Review
Iatrogenic anetoderma of prematurity (IAOP) represents a benign iatrogenic dermatosis characterized by focal, well-demarcated areas of atrophic skin in preterm infants. We present the cases of 5 infants diagnosed with IAOP during a 3-year period in a tertiary-care university hospital. Skin atrophy patches were absent at birth in all presented infants, and there was no family history of anetoderma. All of the infants were born with very low gestation and birth weight, with a clinical course that was complicated with several serious prematurity-related complications with consequent long periods of unstable vital functions and the need for continuous monitoring. Skin defects consistent with IAOP were located on the previous ECG electrode sites. IAOP changes in all the infants were in the form of oval patches of skin atrophy in the middle chest region, with an additional few small, round patches bellow the nipple on both sides in one girl. Diagnosis of IAOP was based on characteristic clinical findings. IAOP is rare, benign, but permanent skin injury in the most immature of infants, with a potential for considerable aesthetic and psychological burden. Due to the constant increase in survival of very and extremely preterm infants, more often without major developmental consequences, milder complications like IAOP will become more and more important.
Topics: Anetoderma; Female; Humans; Iatrogenic Disease; Infant, Low Birth Weight; Infant, Newborn; Infant, Premature, Diseases; Male; Prognosis; Vital Signs
PubMed: 32876031
DOI: No ID Found -
Journal of Cutaneous Pathology Oct 2015Anetoderma is a cutaneous disorder characterized by loss of dermal elastic tissue resulting in papules from herniation of subcutaneous tissue or circumscribed areas of... (Review)
Review
Anetoderma is a cutaneous disorder characterized by loss of dermal elastic tissue resulting in papules from herniation of subcutaneous tissue or circumscribed areas of atrophic, wrinkled skin. Familial leiomyomatosis cutis et uteri (Reed syndrome) is an autosomal dominant disorder characterized by cutaneous and uterine leiomyomas. We report a 23-year-old male with Reed syndrome who presented with asymptomatic pearly white, atrophic, flaccid papules on the upper back and shoulder that depressed when palpated. Pathologic examination showed an unremarkable epidermis and central loss of dermal elastin, bordered by clumped elastin, as revealed with an elastin stain. The correlation of clinical and pathologic findings indicated a diagnosis of anetoderma arising in a patient with Reed syndrome.
Topics: Adult; Anetoderma; Atrophy; Biopsy; Elastic Tissue; Humans; Leiomyomatosis; Male; Neoplastic Syndromes, Hereditary; Skin Neoplasms; Subcutaneous Tissue; Uterine Neoplasms
PubMed: 25950901
DOI: 10.1111/cup.12524 -
Clinical and Experimental Dermatology Aug 2015
Topics: Adult; Anetoderma; Cocaine-Related Disorders; Humans; Male
PubMed: 25703260
DOI: 10.1111/ced.12602 -
Clinical Case Reports Dec 2020Anetoderma is a rare cutaneous disorder presenting with atrophic skin lesions. It can be associated with several autoimmune and infectious diseases. With the current...
Anetoderma is a rare cutaneous disorder presenting with atrophic skin lesions. It can be associated with several autoimmune and infectious diseases. With the current resurgence of syphilis, clinicians must be aware of its association with anetoderma.
PubMed: 33363992
DOI: 10.1002/ccr3.3290