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International Journal of Molecular... Oct 2022Cotton is an important economic crop. and are the primary pathogenic fungi that threaten both the quality and sustainable production of cotton. As an opportunistic... (Review)
Review
Cotton is an important economic crop. and are the primary pathogenic fungi that threaten both the quality and sustainable production of cotton. As an opportunistic pathogen, causes various human diseases, including fungal keratitis, which is the most common. Therefore, there is an urgent need to study and clarify the resistance mechanisms of cotton and humans toward in order to mitigate, or eliminate, its harm. Herein, we first discuss the resistance and susceptibility mechanisms of cotton to and wilt and classify associated genes based on their functions. We then outline the characteristics and pathogenicity of and describe the multiple roles of human neutrophils in limiting hyphal growth. Finally, we comprehensively compare the similarities and differences between animal and plant resistance to and put forward new insights into novel strategies for cotton disease resistance breeding and treatment of infection in humans.
Topics: Humans; Verticillium; Fusarium; Plant Diseases; Plant Breeding; Disease Resistance; Gossypium; Defense Mechanisms
PubMed: 36293072
DOI: 10.3390/ijms232012217 -
Cortex; a Journal Devoted To the Study... Dec 2014Unawareness of hemiplegia was first called anosognosia by Babinski one century ago. This paper reviews some of the major theories that may account for this disorder.... (Review)
Review
Unawareness of hemiplegia was first called anosognosia by Babinski one century ago. This paper reviews some of the major theories that may account for this disorder. Weinstein and Kahn posited that anosognosia was a psychological defense mechanism; however, clinical as well as studies using transient hemispheric anesthesia reveal anosognosia for hemiplegia is more commonly associated with right than left hemisphere dysfunction, which is not entirely compatible with this denial hypothesis. Discovery is dependent on sensory feedback. Some patients with anosognosia will recognize their hemiparesis when their paretic hand is placed into ipsilesional hemispace suggesting that de-afferentation and inattention-neglect may be important mechanisms. Some patients with anosognosia have asomatognosia and hence being unaware that their paretic arm belongs to them they do not recognize that they have a deficit. Some patients have phantom movements and some may confabulate because they have a hemispheric disconnection. The feed-forward hypothesis posits that without an attempt to move, there is no expectation of movement and in the absence of arm movement there will be no discord that leads to discovery. Thus, motor neglect may be another cause of anosognosia. A defect in a theoretical comparator where expectations are compared to feedback may also be a cause of anosognosia, but further evidence is needed to support this postulate. Based on the studies of anosognosia for hemiplegia we have reviewed it appears that normal self-awareness depends on several modular systems. Further research of these possible mechanisms is needed to discern their relative importance and treatment. If these mechanisms do not fully account for anosognosia, investigators will need to develop and test new hypotheses.
Topics: Agnosia; Awareness; Denial, Psychological; Hemiplegia; Humans; Learning; Movement
PubMed: 25023619
DOI: 10.1016/j.cortex.2014.06.007 -
BMJ Open Respiratory Research Jul 2023Epidemiological and clinical studies have indicated an association between particulate matter (PM) exposure and acute and chronic pulmonary inflammation, which may be... (Review)
Review
Epidemiological and clinical studies have indicated an association between particulate matter (PM) exposure and acute and chronic pulmonary inflammation, which may be registered as increased mortality and morbidity. Despite the increasing evidence, the pathophysiology mechanism of these PMs is still not fully characterised. Pulmonary alveolar macrophages (PAMs), as a predominant cell in the lung, play a critically important role in these pathological mechanisms. Toxin exposure triggers events associated with macrophage activation, including oxidative stress, acute damage, tissue disruption, remodelling and fibrosis. Targeting macrophage may potentially be employed to treat these types of lung inflammation without affecting the natural immune response to bacterial infections. Biological toxins, their sources of exposure, physical and other properties, and their effects on the individuals are summarised in this article. Inhaled particulates from air pollution and toxic gases containing chemicals can interact with alveolar epithelial cells and immune cells in the airways. PAMs can sense ambient pollutants and be stimulated, triggering cellular signalling pathways. These cells are highly adaptable and can change their function and phenotype in response to inhaled agents. PAMs also have the ability to polarise and undergo plasticity in response to tissue damage, while maintaining resistance to exposure to inhaled agents.
Topics: Humans; Macrophages, Alveolar; Air Pollution; Gases; Lung; Defense Mechanisms
PubMed: 37479504
DOI: 10.1136/bmjresp-2022-001589 -
Integrative Psychological & Behavioral... Jun 2020The concept of defense mechanism is interwoven with psychoanalytic theories of anxiety and psychic conflict. From its first formulation in 1894, its usefulness resides...
The concept of defense mechanism is interwoven with psychoanalytic theories of anxiety and psychic conflict. From its first formulation in 1894, its usefulness resides in the degree to which it helps to explain otherwise mysterious phenomena. Statistical approaches to the study of defense mechanisms, which have significantly increased in popularity in the past three decades, test isolated assumptions without reflection on how these are integrated into psychoanalytic theory, nor on what should be regarded as psychoanalytic data. Consequently, their results and their models have not provided useful insights into psychoanalytic theory. This paper aims to show how these issues in statistical approaches largely stem from disregarding discussions on the ontological status of defense mechanisms and the epistemological consequences linked to them. Studying defense mechanisms as they are manifested in external lifestyles, clouds the distinction between constructs (explanatory terms) and phenomena (empirical referents), which is furthermore necessary for a theoretical model to have explanatory value. Concrete examples are given regarding problems in statistical conceptualizations of defense mechanisms as well as the cursory explanations these tend to describe. Implications for future research are discussed.
Topics: Defense Mechanisms; Humans; Psychoanalysis; Psychoanalytic Theory
PubMed: 31955367
DOI: 10.1007/s12124-020-09515-6 -
Journal of Affective Disorders Jan 2021Accumulating evidence has converged to suggest that childhood trauma may contribute to bipolar disorder (BD). This study aimed to investigate the patterns of childhood...
BACKGROUND
Accumulating evidence has converged to suggest that childhood trauma may contribute to bipolar disorder (BD). This study aimed to investigate the patterns of childhood trauma among patients with bipolar I (BD-I) and bipolar II (BD-II) disorders, according to DSM-IV and in contrast with healthy volunteers. We also explored whether the relationship between childhood trauma and onset of bipolar disorder is mediated by immature defense mechanisms.
METHODS
Participants were patients with BD-I (n=44) and BD-II (n = 42), and healthy controls (HCs, n = 43). Childhood traumatic experiences and defense mechanisms were assessed by the Childhood Trauma Questionnaire (CTQ) and the Defense Style Questionnaire (DSQ), respectively.
RESULTS
BD patients experienced more severe childhood trauma than HCs. Physical neglect sub-score and total score of the CTQ had both direct and indirect effects on the diagnosis of BD-I, and an immature defense style mediated the indirect effects. The diagnosis of BD-II was mainly related to the physical neglect and emotional abuse subs-core and total score of the CTQ, as mediated by the immature defense mechanisms. BD-I and BD-II significantly differed in the emotional abuse sub-score of the CTQ.
CONCLUSIONS
Physical neglect sub-score and total score of the CTQ were associated with the diagnosis of BD (both BD-I and BD-II), as mediated by an immature defense style. Furthermore, emotional abuse might be an important risk factor for BD-II compared to BD-I. These findings may inform risk reduction and psychosocial intervention strategies to prevent and treat patients with bipolar disorders.
Topics: Adult Survivors of Child Abuse; Bipolar Disorder; Child; Child Abuse; Defense Mechanisms; Diagnostic and Statistical Manual of Mental Disorders; Humans; Surveys and Questionnaires
PubMed: 33125910
DOI: 10.1016/j.jad.2020.10.029 -
International Journal of Environmental... Oct 2022Emotion regulation is an important aspect of psychological functioning that influences subjective experience and moderates emotional responses throughout the lifetime....
Emotion regulation is an important aspect of psychological functioning that influences subjective experience and moderates emotional responses throughout the lifetime. Adaptive responses to stressful life events depend on the positive interaction between explicit and implicit emotion regulation strategies, such as mindfulness and defense mechanisms. This study demonstrates how these emotion regulation strategies predict psychological health during the early phase of the COVID-19 pandemic. A convenience sample of 6385 subjects, recruited via snowball sampling on various social media platforms, responded to an online survey assessing psychological reaction to social restrictions imposed to limit the spread of COVID-19 in Italy. Psychological distress, post-traumatic stress symptoms, mindfulness, and defense mechanisms were assessed using SCL-90, IES-R, MAAS, and DMRS-30-SR, respectively. Higher mindfulness was significantly associated with higher overall defensive maturity and a greater use of high-adaptive defenses ( < 0.0001). Both mindfulness and defense mechanisms acted as good predictors of psychological health (R = 0.541) and posttraumatic symptoms (R = 0.332), confirming the role of emotion regulation in protecting against maladaptive responses to stressful situations.
Topics: COVID-19; Defense Mechanisms; Emotional Regulation; Humans; Mindfulness; Pandemics; Psychological Distress
PubMed: 36231993
DOI: 10.3390/ijerph191912690 -
The American Journal of Psychiatry Feb 2016
Topics: Defense Mechanisms; Emotions; Female; Humans; Male; Mother-Child Relations; Mothers; Object Attachment; Pregnancy; Pregnant Women; Problem Behavior; Social Skills
PubMed: 26844788
DOI: 10.1176/appi.ajp.2015.15111501 -
American Journal of Psychoanalysis Mar 2016In our view helplessness is a primal, often intolerable feeling. It underlies and intensifies other feelings that are also hard to bear. Both analyst and patients face... (Review)
Review
In our view helplessness is a primal, often intolerable feeling. It underlies and intensifies other feelings that are also hard to bear. Both analyst and patients face helplessness, and both resort to defenses, often intensely, in order to avoid it. The intensity of this battle can merit calling it a war. The analyst's war is conducted using distancing, anger, blaming and disparaging as well as by intellectualizing the patient's struggles. Patients then find themselves abandoned and helplessly alone. We analysts, of course, want not to fall into the trap of war, and we try to free ourselves from waging it. A major way we accomplish this is through continuously working, often with the help of analysis and self-analysis, to increase our capacity to maintain our emotional stability in the face of these intensities. We learn to find new forms of awareness, beyond words and ideas. It requires a new understanding of what is threatening to us, which fosters a deeper capacity to empathize with the patient. This helps us to find the psychic, physical and emotional space within ourselves in which to hold our helplessness and other profound affective experiences. In this way we become an increasingly steady resource for our patients as well as for ourselves.
Topics: Countertransference; Defense Mechanisms; Emotions; Helplessness, Learned; Humans; Professional-Patient Relations; Psychoanalysis
PubMed: 26912242
DOI: 10.1057/ajp.2015.56 -
Microbiology Spectrum Apr 2016Invading pathogens are exposed to a multitude of harmful conditions imposed by the host gastrointestinal tract and immune system. Bacterial defenses against these... (Review)
Review
Invading pathogens are exposed to a multitude of harmful conditions imposed by the host gastrointestinal tract and immune system. Bacterial defenses against these physical and chemical stresses are pivotal for successful host colonization and pathogenesis. Enteric pathogens, which are encountered due to the ingestion of or contact with contaminated foods or materials, are highly successful at surviving harsh conditions to colonize and cause the onset of host illness and disease. Pathogens such as Campylobacter, Helicobacter, Salmonella, Listeria, and virulent strains of Escherichia have evolved elaborate defense mechanisms to adapt to the diverse range of stresses present along the gastrointestinal tract. Furthermore, these pathogens contain a multitude of defenses to help survive and escape from immune cells such as neutrophils and macrophages. This chapter focuses on characterized bacterial defenses against pH, osmotic, oxidative, and nitrosative stresses with emphasis on both the direct and indirect mechanisms that contribute to the survival of each respective stress response.
Topics: Adaptation, Physiological; Animals; Bacteria; Bacterial Physiological Phenomena; Defense Mechanisms; Gastrointestinal Tract; Humans; Microbial Viability; Stress, Physiological; Virulence
PubMed: 27227312
DOI: 10.1128/microbiolspec.VMBF-0007-2015 -
Current Biology : CB Nov 2023The aerial surfaces of quinoa (Chenopodium quinoa) and common ice plant (Mesembryanthemum crystallinum) are covered with a layer of epidermal bladder cells (EBCs), which...
The aerial surfaces of quinoa (Chenopodium quinoa) and common ice plant (Mesembryanthemum crystallinum) are covered with a layer of epidermal bladder cells (EBCs), which are modified non-glandular trichomes previously considered to be key to the extreme salt and drought tolerance of these plants. Here, however, we find that EBCs of these plants play only minor roles, if any, in abiotic stress tolerance and in fact are detrimental under conditions of water deficit. We report that EBCs instead function as deterrents to a broad range of generalist arthropod herbivores, through their combined function of forming both a chemical and a physical barrier, and they also serve a protective function against a phytopathogen. Our study overturns current models that link EBCs to salt and drought tolerance and assigns new functions to these structures that might provide novel possibilities for protecting crops from arthropod pests.
Topics: Herbivory; Urinary Bladder; Sodium Chloride; Plants; Defense Mechanisms
PubMed: 37852262
DOI: 10.1016/j.cub.2023.09.063