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Journal of Prosthodontic Research 2023
Topics: Prosthodontics; Dental Materials; Dental Prosthesis Design; Biomimetic Materials
PubMed: 37045755
DOI: 10.2186/jpr.JPR_D_23_00081 -
Dental Materials : Official Publication... Jan 2018Clinical studies should be one main aspect underlying dentists' decision-making towards dental materials. Study design, conduct, analysis and reporting impact on the... (Review)
Review
OBJECTIVE
Clinical studies should be one main aspect underlying dentists' decision-making towards dental materials. Study design, conduct, analysis and reporting impact on the usefulness of studies. We discuss problems with current studies and highlight areas where improvement might be possible.
METHODS
Based on systematically and non-systematically collected data, we demonstrate where and why current studies in clinical dentistry deliver less-than-optimal results. Lending from general medicine, we suggest ways forward for clinical dental material science.
RESULTS
Randomized controlled (efficacy) trials remain a major pillar in dental material science, as they reduce selection bias and, if well-designed and conducted, have high internal validity. Given their costs and limited external validity, alternatives like practice-based or pragmatic controlled trials or observational studies can complement the evidence-base. Prior to conduct, researchers should focus on study comparators and setting (answering questions with relevance to clinical dentistry), and pay attention to statistical power, considering the study aim (superiority or non-inferiority trial), the expected event rate, and attrition. Study outcomes should be chosen on the basis of a core outcome set or, if not available, involving patients and other stakeholders. Studies should be registered a priori, and reporting should adhere to standards. Possible clustering should be accounted for during statistical analysis.
SIGNIFICANCE
Many clinical studies in dental material science are underpowered, and of limited validity and usefulness for daily decision-making. Dental researchers should mirror existing efforts in other medical fields in making clinical studies more valid and applicable, thus contributing to better dental care.
Topics: Decision Making; Dental Materials; Dental Research; Dental Restoration, Permanent; Humans; Randomized Controlled Trials as Topic; Research Design
PubMed: 28988780
DOI: 10.1016/j.dental.2017.09.009 -
Journal of Biomedical Materials... Aug 2020Due to the excellent restoration of masticatory function, satisfaction on aesthetics and other superiorities, dental implants represent an effective method to resolve... (Review)
Review
Due to the excellent restoration of masticatory function, satisfaction on aesthetics and other superiorities, dental implants represent an effective method to resolve tooth losing and damaging. Current dental implant systems still have problems waiting to be addressed, and problems are centralized on the materials of implant bodies. This review aims to summarize major developments in the field of dental implant materials, starting with an overview on structures, procedures of dental implants and challenges of implant materials. Next, implant materials are examined in three categories, that is, metals, ceramics, and polymers, their mechanical properties, biocompatibility, and bioactivity are summarized. And as an important aspect, strategies of surface modification are also reviewed, along with some finite element analysis to guiding the research direction of implant materials. Finally, the conclusive remarks are outlined to provide an outlook on the future research directions and prospects of dental implants.
Topics: Biocompatible Materials; Dental Implants; Dental Materials; Finite Element Analysis; Humans; Materials Testing; Prosthesis Design
PubMed: 32196913
DOI: 10.1002/jbm.a.36931 -
International Journal of Molecular... Oct 2018Oral biofilms attach onto both teeth surfaces and dental material surfaces in oral cavities. In the meantime, oral biofilms are not only the pathogenesis of dental... (Review)
Review
Oral biofilms attach onto both teeth surfaces and dental material surfaces in oral cavities. In the meantime, oral biofilms are not only the pathogenesis of dental caries and periodontitis, but also secondary caries and peri-implantitis, which would lead to the failure of clinical treatments. The material surfaces exposed to oral conditions can influence pellicle coating, initial bacterial adhesion, and biofilm formation, due to their specific physical and chemical characteristics. To define the effect of physical and chemical characteristics of dental prosthesis and restorative material on oral biofilms, we discuss resin-based composites, glass ionomer cements, amalgams, dental alloys, ceramic, and dental implant material surface properties. In conclusion, each particular chemical composition (organic matrix, inorganic filler, fluoride, and various metallic ions) can enhance or inhibit biofilm formation. Irregular topography and rough surfaces provide favorable interface for bacterial colonization, protecting bacteria against shear forces during their initial reversible binding and biofilm formation. Moreover, the surface free energy, hydrophobicity, and surface-coating techniques, also have a significant influence on oral biofilms. However, controversies still exist in the current research for the different methods and models applied. In addition, more in situ studies are needed to clarify the role and mechanism of each surface parameter on oral biofilm development.
Topics: Bacterial Adhesion; Biofilms; Dental Materials; Dental Prosthesis; Humans; Mouth; Surface Properties
PubMed: 30322190
DOI: 10.3390/ijms19103157 -
Methods in Molecular Biology (Clifton,... 2023Dental materials are specially fabricated materials designed for use in dentistry. A variety of materials may be used, including cements, impression, lining, and dental...
Dental materials are specially fabricated materials designed for use in dentistry. A variety of materials may be used, including cements, impression, lining, and dental restorative materials. Some of these dental materials provide temporary dressings while others are more permanent and are in contact with host tissue for prolonged periods of time. Consequently, newly developed dental materials not only require mechanical, chemical, and physical testing but also require in vitro analysis to ensure their safety and biocompatibility. The current chapter provides background on dental material characterization and a protocol for its in vitro biological testing.
Topics: In Vitro Techniques; Dental Materials
PubMed: 36418708
DOI: 10.1007/978-1-0716-2780-8_31 -
Biotechnology and Bioengineering Dec 2021Several approaches for elimination of oral pathogens are being explored at the present time since oral diseases remain prevalent affecting approximately 3.5 billion... (Review)
Review
Several approaches for elimination of oral pathogens are being explored at the present time since oral diseases remain prevalent affecting approximately 3.5 billion people worldwide. Need for antimicrobial biomaterials in dental healthcare include but is not restricted to designing resin composites and adhesives for prevention of dental caries. Constant efforts are also being made to develop antimicrobial strategies for clearance of endodontic space prior root canal treatment and for treatment of periimplantitis and periodontitis. This article discusses various conventional and nanotechnology-based strategies to achieve antimicrobial efficacy in dental biomaterials. Recent developments in the design and synthesis of antimicrobial peptides and antifouling zwitterionic polymers to effectively lessen the risks of antimicrobial drug resistance are also outlined in this review. Further, the role of contemporary strategies such as use of smart biomaterials, ionic solvent-based biomaterials and quorum quenchers incorporated biomaterials in the elimination of dental pathogens are described in detail. Lastly, we mentioned the approach of using polymers to print custom-made three-dimensional antibacterial dental products via additive manufacturing technologies. This review provides a critical perspective on the chemical, biomimetic, and engineering strategies intended for developing antimicrobial biomaterials that have the potential to substantially improve the dental health.
Topics: Animals; Anti-Infective Agents; Antimicrobial Peptides; Biocompatible Materials; Dental Caries; Dental Materials; Humans; Mice; Nanostructures; Oral Health; Printing, Three-Dimensional
PubMed: 34599764
DOI: 10.1002/bit.27948 -
Biomaterials Science Jun 2018Cyanoacrylate adhesives and their homologues have elicited interest over the past few decades owing to their applications in the biomedical sector, extending from tissue... (Review)
Review
Cyanoacrylate adhesives and their homologues have elicited interest over the past few decades owing to their applications in the biomedical sector, extending from tissue adhesives to scaffolds to implants to dental material and adhesives, because of their inherent biocompatibility and ability to polymerize solely with moisture, thanks to which they adhere to any substrate containing moisture such as the skin. The ability to tailor formulations of alkyl cyanoacrylate to form derivative compounds to meet application requirements along with their biodegradability in conjunction with their inherent biocompatibility make them highly sought after candidates in the biomedical sector. There has been extensive exploration of cyanoacrylate adhesives and their homologue systems in biomedical applications, but no consolidated literature of the vast data is available. The ability of cyanoacrylate adhesives to cure at low temperatures and without the need for any hardener, which is attributed to the high-strength bonding interaction between two non-amalgamating substrates, with their ease of dispersion and self-curing, avoids the curtailing of the effective utilization of such adhesives in biomedical engineering applications as bio glues for amalgamating tissues, implants, scaffolds etc. This article consolidates copious work on cyanoacrylate adhesives and their derived systems which are functional in versatile biomedical engineering applications such as bio glues, dental material and adhesives and other potential applications.
Topics: Adhesives; Animals; Biocompatible Materials; Cyanoacrylates; Dental Materials; Drug Delivery Systems; Humans; Prostheses and Implants; Tissue Adhesives; Tissue Engineering; Tissue Scaffolds
PubMed: 29786707
DOI: 10.1039/c8bm00312b -
Pediatric Dentistry 2015The purpose of this paper was to review the current literature associated with the techniques and materials for the restoration of primary anterior teeth and make... (Review)
Review
The purpose of this paper was to review the current literature associated with the techniques and materials for the restoration of primary anterior teeth and make clinical recommendations based upon the available literature. A variety of esthetic restorative materials are available to utilize for restoring primary incisors. Awareness of the specific strengths, weakness, and properties of each material can enhance the clinician's ability to make the best choice of selection for each individual situation. Intracoronal restorations of primary teeth may utilize resin composites, glass ionomer cements, resin-modified ionomers, or polyacid-modified resins. Full coronal restoration of primary incisors may be indicated for a number of reasons. Crowns available for restoration of primary incisors include those that are directly bonded onto the tooth, which generally are a resin material, and crowns that are luted onto the tooth and are either some type of stainless steel or zirconia crown. There is insufficient controlled, clinical data to suggest that one type of restoration is superior to another. Operator preferences, esthetic demands by parents, the child's behavior, the amount of tooth structure remaining, and moisture and hemorrhage control are all variables that affect the decision and ultimate outcome of whatever restorative solution is chosen.
Topics: Crowns; Cuspid; Dental Alloys; Dental Cements; Dental Materials; Dental Restoration, Permanent; Humans; Incisor; Tooth, Deciduous
PubMed: 25905657
DOI: No ID Found -
Current Pharmaceutical Design 2016Energy intensive and chemical routes predominately govern modern dental material fabrication involving complex physicochemical approaches. Current interest in dental... (Review)
Review
Energy intensive and chemical routes predominately govern modern dental material fabrication involving complex physicochemical approaches. Current interest in dental material design is shifting towards biomineralization method and green chemistry synthesis to support oral tissue biocompatibility and oropharmacology. This review article describes the context of biophysical approaches based on development in nanoengineering to design advance nanomaterials for clinical dentistry. We particularly focus on approaches governing surface texture and hierarchical assembly emphasis based on micro-nanoscale tooth anatomy. Further, this article provides an overview about the merit of micro-nanoscale material design techniques exchanging the traditional dental material. In this context, top-down and bottom-up approaches involving biomimetic nanoengineering route, opportunities and challenges are discussed.
Topics: Biomimetics; Dental Materials; Dentistry; Humans; Nanostructures; Nanotechnology
PubMed: 26675228
DOI: 10.2174/1381612822666151210124001 -
The Journal of Clinical Pediatric... 2015The science of dental materials and restorative care in children and adolescent is constantly evolving, and the ongoing search for ideal restorative materials has led to... (Review)
Review
BACKGROUND
The science of dental materials and restorative care in children and adolescent is constantly evolving, and the ongoing search for ideal restorative materials has led to plethora of research.
AIM
To provide an evidence base to assist dental practitioners choose appropriate restorative care for children and adolescents.
STUDY DESIGN
This evidence-based review appraises this literature, primarily between the years 1995-2013, for efficacy of dental amalgam, composites, glass ionomer cements, compomers, preformed metal crowns and anterior esthetic restorations. The assessment of evidence for each dental material was based on a strong evidence, evidence in favor, expert opinion, and evidence against by consensus of the authors.
RESULTS
There is varying level of evidence for the use of restorative materials like amalgam, composites, glass ionomers, resin-modified glass-ionomers, compomers, stainless steel crowns and anterior crowns for both primary and permanent teeth.
CONCLUSIONS
A substantial amount data is available on restorative materials used in pediatric dentistry; however, there exists substantial evidence from systematic reviews and randomized clinical trials and clinicians need to examine and understand the available literature evidence carefully to aid them in clinical decision making.
Topics: Adolescent; Child; Crowns; Dental Materials; Dental Restoration, Permanent; Evidence-Based Dentistry; Humans
PubMed: 26161599
DOI: 10.17796/1053-4628-39.4.303