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Current Diabetes Reports Sep 2015Comparative results from national strategies for diabetes care and prevention are needed to understand the impact and barriers encountered during the implementation... (Review)
Review
Comparative results from national strategies for diabetes care and prevention are needed to understand the impact and barriers encountered during the implementation process. Long-term outcomes are limited, but results on intermediate outcomes and processes of diabetes care measures are available from translational research studies. In this narrative review, we highlight programs with nationwide reach, targeting various ethnic, racial, and socioeconomic populations with diabetes. We describe the implementation strategies, the impact on clinical outcomes, specific barriers, and cost-effectiveness results of national efforts aimed at improving diabetes care and prevention in the USA.
Topics: Cost-Benefit Analysis; Diabetes Complications; Diabetes Mellitus; Humans; National Health Programs
PubMed: 26255260
DOI: 10.1007/s11892-015-0637-y -
Current Diabetes Reports Feb 2019Older adults often live with chronic disease including diabetes and its complications. In this review, we examine the complexity and heterogeneity of older adults with... (Review)
Review
PURPOSE OF REVIEW
Older adults often live with chronic disease including diabetes and its complications. In this review, we examine the complexity and heterogeneity of older adults with diabetes and chronic kidney disease, explore the nuances in their diabetes-related monitoring, and discuss their best diabetes management.
RECENT FINDINGS
Although there remains an overall lack of studies in older adults with diabetes and chronic kidney disease, recent reports have highlighted their vulnerabilities. These individuals face an increased risk of cognitive impairment and dementia, frailty, dysglycemia, polypharmacy, declining kidney function, and acute kidney injury. Their diabetes management should focus upon safer antihyperglycemic medications, close monitoring, and care individualization. Older adults with diabetes and chronic kidney disease are a complex population who requires careful diabetes management and monitoring. Research efforts might focus on improving the care and outcomes of these patients.
Topics: Aged; Diabetes Complications; Diabetic Nephropathies; Humans; Hypoglycemic Agents; Monitoring, Physiologic; Precision Medicine; Renal Insufficiency, Chronic
PubMed: 30771017
DOI: 10.1007/s11892-019-1128-3 -
Endocrinology and Metabolism Clinics of... Mar 2018Hypertension is an important and modifiable risk factor for the macrovascular and microvascular complications of diabetes. Prior literature outlines the significance of... (Review)
Review
Hypertension is an important and modifiable risk factor for the macrovascular and microvascular complications of diabetes. Prior literature outlines the significance of lowering blood pressure and subsequent cardiovascular and microvascular benefits. Blood pressure targets of less than 140/90 mm Hg are recommended in all adults with diabetes, with lower blood pressure targets of less than 130/80 mm Hg beneficial for those with higher cardiovascular disease risk. Treatment to lower blood pressure is primarily based on a foundation of lifestyle modifications, low sodium diet, exercise, and good sleep hygiene coupled with multiple medication classes such as renin angiotensin system inhibitors.
Topics: Antihypertensive Agents; Diabetes Complications; Diabetes Mellitus, Type 2; Humans; Hypertension; Kidney Diseases
PubMed: 29407050
DOI: 10.1016/j.ecl.2017.10.008 -
Diabetic Medicine : a Journal of the... Jan 2018The increasing global prevalence of diabetes mellitus presents a significant challenge to healthcare systems today. Although diabetic retinopathy, nephropathy and... (Review)
Review
The increasing global prevalence of diabetes mellitus presents a significant challenge to healthcare systems today. Although diabetic retinopathy, nephropathy and neuropathy are well-established complications of diabetes, there is a paucity of research examining the impact of dysglycaemia on the olfactory system. Olfaction is an important sense, playing a role in the safety, nutrition and quality of life of an individual, but its importance is often overlooked when compared with the other senses. As a result, olfactory dysfunction is often underdiagnosed. The present review article aims to present and discuss the available evidence on the relationship between diabetes and olfaction. It also explores the associations between olfactory dysfunction and diabetes complications that could explain the underlying pathogenesis. Finally, it summarizes the putative pathological mechanisms underlying olfactory dysfunction in diabetes that require further investigation.
Topics: Albuminuria; Diabetes Complications; Diabetes Mellitus; Diabetic Nephropathies; Diabetic Neuropathies; Humans; Olfaction Disorders; Oxidative Stress
PubMed: 29108100
DOI: 10.1111/dme.13542 -
Life Sciences Aug 2021Diabetes epidemiological quantities are demonstrating one of the most important communities' health worries. The essential diabetic difficulties are including... (Review)
Review
Diabetes epidemiological quantities are demonstrating one of the most important communities' health worries. The essential diabetic difficulties are including cardiomyopathy, nephropathy, inflammation, and retinopathy. Despite developments in glucose decreasing treatments and drugs, these diabetic complications are still ineffectively reversed or prohibited. Several signaling and molecular pathways are vital targets in the new therapies of diabetes. This review assesses the newest researches about the key molecules and signaling pathways as targets of molecular pharmacology in diabetes and diseases related to it for better treatment based on molecular sciences. The disease is not cured by current pharmacological strategies for type 2 diabetes. While several drug combinations are accessible that can efficiently modulate glycemia and mitigate long-term complications, these agents do not reverse pathogenesis, and in practice, they are not established to modify the patient's specific molecular profiling. Therapeutic companies have benefited from human genetics. Genome exploration, which is agnostic to the information that exists, has revealed tens of loci that impact glycemic modulation. The physiological report has begun to examine subtypes of diseases, illustrate heterogeneity and propose biochemical therapeutic pathways.
Topics: Animals; Diabetes Complications; Diabetes Mellitus; Drug Discovery; Humans; Hypoglycemic Agents; Molecular Targeted Therapy; Signal Transduction
PubMed: 34019900
DOI: 10.1016/j.lfs.2021.119632 -
Journal of Diabetes and Its... Apr 2022
Topics: Diabetes Complications; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Humans; Oral Health
PubMed: 35256267
DOI: 10.1016/j.jdiacomp.2022.108146 -
Topics in Companion Animal Medicine Mar 2018Diabetes mellitus (DM) is a commonly encountered disease in companion animal veterinary practice. Ocular complications in dogs with DM are thought to be common but there... (Review)
Review
Diabetes mellitus (DM) is a commonly encountered disease in companion animal veterinary practice. Ocular complications in dogs with DM are thought to be common but there are no reports of the overall incidence of DM-associated ocular disease. Some complications, such as cataracts and ocular surface disease, can lead to vision loss and significant morbidity among DM patients, therefore early recognition and intervention are essential for successful outcomes. The purpose of this article is to provide a review of several currently known or suspected ocular diseases associated with DM.
Topics: Animals; Diabetes Complications; Diabetes Mellitus; Dog Diseases; Dogs; Eye Diseases; Incidence
PubMed: 29793726
DOI: 10.1053/j.tcam.2018.03.001 -
BMJ (Clinical Research Ed.) Jan 2015
Topics: Diabetes Complications; Diabetes Mellitus, Type 2; Female; Humans; Neoplasms
PubMed: 25555822
DOI: 10.1136/bmj.g7707 -
International Journal of Medical... 2019Diabetes mellitus is a global issue with increasing incidence rate worldwide. In an uncontrolled case, it can advance to various organ-related complications leading to... (Review)
Review
Diabetes mellitus is a global issue with increasing incidence rate worldwide. In an uncontrolled case, it can advance to various organ-related complications leading to an increase in morbidity and mortality. Long non-coding RNA (lncRNA) Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) appears to be a fairly novel lncRNA that is relevant to diabetes and its role in diabetic-related diseases initiation and progression have long been a subject of attention to many scholars. The expression of MALAT1 is elevated in different diabetic-related diseases. In this review, we demonstrate the various functions of MALAT1 in the different diabetes-related complications including ischemic reperfusion injury, retinopathy, cataract, atherosclerosis, cardiomyopathy, non-alcoholic steatohepatitis, gastroparesis, kidney disease, and gestational diabetes. The emerging evidence showed that the role of MALAT1 in diabetic-related complications is both pro-inflammatory and apoptosis in different cell types. These results concluded that MALAT1 is a potential diagnostic and future targeted therapy for diabetes-associated complications.
Topics: Apoptosis; Cell Lineage; Diabetes Complications; Gene Expression Regulation; Humans; Inflammation; RNA, Long Noncoding
PubMed: 31171906
DOI: 10.7150/ijms.30097 -
BioMed Research International 2017The occurrence of hepatocellular carcinoma (HCC) is two to three times higher in patients with diabetes mellitus (DM), the prevalence of which is increasing sharply... (Review)
Review
The occurrence of hepatocellular carcinoma (HCC) is two to three times higher in patients with diabetes mellitus (DM), the prevalence of which is increasing sharply worldwide. The purpose of this review was to describe clinical links between DM and HCC and potential biological mechanisms that may account for this association. We evaluated the role of potential pathways that could account for the development of HCC with different etiologies in the presence of DM. In addition, we also briefly discuss the potential effect of other factors such as type and dosage of antidiabetic medicines and duration of DM on HCC risk.
Topics: Animals; Carcinoma, Hepatocellular; Diabetes Complications; Humans; Liver Neoplasms; Risk Factors
PubMed: 29379799
DOI: 10.1155/2017/5202684