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Frontiers in Human Neuroscience 2022Number processing abilities are important for academic and personal development. The course of initial specialization of ventral occipito-temporal cortex (vOTC)...
Number processing abilities are important for academic and personal development. The course of initial specialization of ventral occipito-temporal cortex (vOTC) sensitivity to visual number processing is crucial for the acquisition of numeric and arithmetic skills. We examined the visual N1, the electrophysiological correlate of vOTC activation across five time points in kindergarten (T1, mean age 6.60 years), middle and end of first grade (T2, 7.38 years; T3, 7.68 years), second grade (T4, 8.28 years), and fifth grade (T5, 11.40 years). A combination of cross-sectional and longitudinal EEG data of a total of 62 children (35 female) at varying familial risk for dyslexia were available to form groups of 23, 22, 27, 27, and 42 participants for each of the five time points. The children performed a target detection task which included visual presentation of single digits (DIG), false fonts (FF), and letters (LET) to derive measures for coarse (DIG vs. FF) and fine (DIG vs. LET) digit sensitive processing across development. The N1 amplitude analyses indicated coarse and fine sensitivity characterized by a stronger N1 to digits than false fonts across all five time points, and stronger N1 to digits than letters at all but the second (T2) time point. In addition, lower arithmetic skills were associated with stronger coarse N1 digit sensitivity over the left hemisphere in second grade (T4), possibly reflecting allocation of more attentional resources or stronger reliance on the verbal system in children with poorer arithmetic skills. To summarize, our results show persistent visual N1 sensitivity to digits that is already present early on in pre-school and remains stable until fifth grade. This pattern of digit sensitivity development clearly differs from the relatively sharp rise and fall of the visual N1 sensitivity to words or letters between kindergarten and middle of elementary school and suggests unique developmental trajectories for visual processing of written characters that are relevant to numeracy and literacy.
PubMed: 35959243
DOI: 10.3389/fnhum.2022.887413 -
Cortex; a Journal Devoted To the Study... Feb 2024The processing of numerals as visual objects is supported by an "Inferior Temporal Numeral Area" (ITNA) in the bilateral inferior temporal gyri (ITG). Extant findings...
The processing of numerals as visual objects is supported by an "Inferior Temporal Numeral Area" (ITNA) in the bilateral inferior temporal gyri (ITG). Extant findings suggest some degree of hemispheric asymmetry in how the bilateral ITNAs process numerals. Pollack and Price (2019) reported such a hemispheric asymmetry by which a region in the left ITG was sensitive to digits during a visual search for a digit among letters, and a homologous region in the right ITG that showed greater digit sensitivity in individuals with higher calculation skills. However, the ITG regions were localized with separate analyses without directly contrasting their digit sensitivities and relation to calculation skills. So, the extent of and reasons for these functional asymmetries remain unclear. Here we probe whether the functional and representational properties of the ITNAs are asymmetric by applying both univariate and multivariate region-of-interest analyses to Pollack and Price's (2019) data. Contrary to the implications of the original findings, digit sensitivity did not differ between ITNAs, and digit sensitivity in both left and right ITNAs was associated with calculation skills. Representational similarity analyses revealed that the overall representational geometries of digits in the ITNAs were also correlated, albeit weakly, but the representational contents of the ITNAs were largely inconclusive. Nonetheless, we found a right lateralization in engagement in alphanumeric categorization, and that the right ITNA showed greater discriminability between digits and letters. Greater right lateralization of digit sensitivity and digit discriminability in the left ITNA were also related to higher calculation skills. Our findings thus suggest that the ITNAs may not be functionally identical and should be directly contrasted in future work. Our study also highlights the importance of within-individual comparisons for understanding hemispheric asymmetries, and analyses of individual differences and multivariate features to uncover effects that would otherwise be obscured by averages.
Topics: Humans; Magnetic Resonance Imaging; Functional Laterality; Temporal Lobe; Multivariate Analysis; Individuality; Brain Mapping
PubMed: 37992508
DOI: 10.1016/j.cortex.2023.08.018 -
Zoological Studies 2020Morphology has a direct influence on animal fitness. Studies addressing the identification of patterns and variations across several guilds are fundamental in...
Morphology has a direct influence on animal fitness. Studies addressing the identification of patterns and variations across several guilds are fundamental in ecomorphological research. Wings are the core of ecological morphology in bats; nevertheless, individual bones and structures that support the wing, including metacarpals, phalanges and the length of digits, have rarely been the subject of comprehensive research when studying wing morphology. Here, I analyzed morphological variations of wing structures across 11 bat guilds and how individual bone structures are correlated to diet, foraging mode and habitat use. I obtained wing measurements from 1512 voucher specimens of 97 species. All the specimens analyzed came from the Mammalian Collection at the Museo Javeriano de Historia Natural of Pontificia Universidad Javeriana (MPUJ-MAMM) (Bogotá, Colombia). Positive correlations between size and the length of the third and fifth digit were detected. Bat guilds that capture their preys using aerial strategy in uncluttered habitats had longer third digits but short fifth digits compared to guilds that rely on gleaning strategy and forage in highly cluttered space. Although terminal phalanges were shown to be important structures for guild classification, metacarpals were strongly related to aerial foragers from uncluttered habitats because of their potential role in flight performance and ecological adaptations. Results show that habitat use, as well as foraging mode, are reflected in wing structures. Different wing traits to those evaluated in this study should be considered to better understand the ecological interactions, foraging strategy, wing adaptations, and flight performance in Neotropical bats.
PubMed: 34140977
DOI: 10.6620/ZS.2020.59-60 -
Developmental Biology Jan 2019Mice are intrinsically capable of regenerating the tips of their digits after amputation. Mouse digit tip regeneration is reported to be a peripheral nerve-dependent...
Mice are intrinsically capable of regenerating the tips of their digits after amputation. Mouse digit tip regeneration is reported to be a peripheral nerve-dependent event. However, it is presently unknown what types of nerves and Schwann cells innervate the digit tip, and to what extent these cells regenerate in association with the regenerative response. Given the necessity of peripheral nerves for mammalian regeneration, we investigated the neuroanatomy of the unamputated, regenerating, and regenerated mouse digit tip. Using immunohistochemistry for β-III-tubulin (β3T) or neurofilament H (NFH), substance P (SP), tyrosine hydroxylase (TH), myelin protein zero (P0), and glial fibrillary acidic protein (GFAP), we identified peripheral nerve axons (sensory and sympathetic), and myelinating- and non-myelinating-Schwann cells. Our findings show that the digit tip is innervated by two digital nerves that each bifurcate into a bone marrow (BM) and connective tissue (CT) branch. The BM branches are composed of sympathetic axons that are ensheathed by non-myelinating-Schwann cells whereas the CT branches are composed of sensory and sympathetic axons and are ensheathed by myelinating- and non-myelinating-Schwann cells. The regenerated digit neuroanatomy differs from unamputated digit in several key ways. First, there is 7.5 fold decrease in CT branch axons in the regenerated digit compared to the unampuated digit. Second, there is a 5.6 fold decrease in myelinating-Schwann cells in the regenerated digit compared to the unamputated digit that is consistent with the decrease in CT branch axons. Importantly, we also find that the central portion of the regenerating digit blastema is aneural, with axons and Schwann cells restricted to peripheral and distal blastema regions. Finally, we show that even with impaired innervation, digits maintain the ability to regenerate after re-amputation. Taken together, these data indicate that nerve regeneration is impaired in the context of mouse digit tip regeneration.
Topics: Amputation, Surgical; Animals; Axons; Female; Glial Fibrillary Acidic Protein; Immunohistochemistry; Mice; Nerve Regeneration; Neurofilament Proteins; Peripheral Nerves; Regeneration; Schwann Cells; Toes; Tubulin
PubMed: 30458171
DOI: 10.1016/j.ydbio.2018.11.010 -
Dementia & Neuropsychologia 2019The digit span test is widely used to assess attention and working memory. It is a portable, relatively culture-free and frequently used test. However, the cultural...
UNLABELLED
The digit span test is widely used to assess attention and working memory. It is a portable, relatively culture-free and frequently used test. However, the cultural validity of this test, particularly in the Indian older population, is not well established.
OBJECTIVE
This study explores the usefulness of the digit span test for Indian older adults with different levels of education.
METHODS
Two hundred and fifty-eight community-dwelling healthy normal older adults formed the sample of this study. All study participants were screened using a semi-structured interview schedule, the modified MINI Screen, the Indian version of the Mini-Mental State Examination, a measure of activities of daily living and the digit span test administered verbally.
RESULTS
The results indicated that participants with higher educational level performed significantly better than low-educated participants on the digit span test. Participants with low education often struggled with the digit span test and resorted to guessing the digits.
CONCLUSION
Our study clearly demonstrates that the digit span test can be useful for educated participants. However, its usefulness and ecological validity is questionable for those with low education and low literacy, warranting future research.
PubMed: 31073387
DOI: 10.1590/1980-57642018dn13-010013 -
Cognitive Science Oct 2023Reading numbers aloud involves visual processes that analyze the digit string and verbal processes that produce the number words. Cognitive models of number reading...
Reading numbers aloud involves visual processes that analyze the digit string and verbal processes that produce the number words. Cognitive models of number reading assume that information flows from the visual input to the verbal production processes-a feed-forward processing mode in which the verbal production depends on the visual input but not vice versa. Here, I show that information flows also in the opposite direction, from verbal production to the visual input processes. Participants read aloud briefly presented multi-digit strings in Hebrew, in which the order of words is congruent with the order of digits (21 = twenty-and-one), and in Arabic, in which the ones word precedes the tens word (one-and-twenty). The error-by-digit-position curve was affected by language: relative to Hebrew, in Arabic the error rate was slightly lower for the unit digit and slightly higher for the decade digit, indicating that in Arabic the unit digit was processed earlier and the decade digit later, in accord with the Arabic word order. This language-dependent processing order originated in the visual level and was not a verbal confound, because it persisted even when I controlled for the serial position of the decade/unit word in the verbal number by using numbers with 0 (two hundred three/two hundred thirty). I conclude that the visual analyzer's digit scanning order, decade-first or unit-first, is not fixed but affected by the language in which the number is produced-a top-down, verbal-to-visual information flow.
Topics: Humans; Reading; Language
PubMed: 37864833
DOI: 10.1111/cogs.13368 -
Developmental Cell Jun 2017Critical steps in forming the vertebrate limb include the positioning of digits and the positioning of joints within each digit. Recent studies have proposed that the...
Critical steps in forming the vertebrate limb include the positioning of digits and the positioning of joints within each digit. Recent studies have proposed that the iterative series of digits is established by a Turing-like mechanism generating stripes of chondrogenic domains. However, re-examination of available data suggest that digits are actually patterned as evenly spaced spots, not stripes, which then elongate into rod-shaped digit rays by incorporating new cells at their tips. Moreover, extension of the digit rays and the patterning of the joints occur simultaneously at the distal tip, implying that an integrated model is required to fully understand these processes.
Topics: Animals; Body Patterning; Extremities; Joints; Organogenesis; Vertebrates
PubMed: 28586643
DOI: 10.1016/j.devcel.2017.04.021 -
Journal of Audiology & Otology Apr 2023The digits-in-noise (DIN) test was developed as a simple and time-efficient hearing-in-noise test worldwide. The Korean version of the DIN (K-DIN) test was previously...
BACKGROUND AND OBJECTIVES
The digits-in-noise (DIN) test was developed as a simple and time-efficient hearing-in-noise test worldwide. The Korean version of the DIN (K-DIN) test was previously validated for both normal-hearing and hearing-impaired listeners. This study aimed to explore the factors influencing the outcomes of the K-DIN test further by analyzing the threshold (representing detection ability) and slope (representing test difficulty) parameters for the psychometric curve fit. Subjects and.
METHODS
In total, 35 young adults with normal hearing participated in the K-DIN test under the following four experimental conditions: 1) background noise (digit-shaped vs. pink noise); 2) gender of the speaker (male vs. female); 3) ear side (right vs. left); and 4) digit presentation levels (55, 65, 75, and 85 dB). The digits were presented using the method of constant stimuli procedure. Participant responses to the stimulus trials were used to fit a psychometric function, and the threshold and slope parameters were estimated according to pre-determined criteria. The accuracy of fit performance was determined using the root-mean-square error calculation.
RESULTS
The listener's digit detection ability (threshold) was slightly better with pink noise than with digit-shaped noise, with similar test difficulties (slopes) across the digits. Gender and the tested ear side influenced neither the detection ability nor the task difficulty. Additionally, lower presentation levels (55 and 65 dB) elicited better thresholds than the higher presentation levels (75 and 85 dB); however, the test difficulty varied slightly across the presentation levels.
CONCLUSIONS
The K-DIN test can be influenced by stimulus factors. Continued research is warranted to understand the accuracy and reliability of the test better, especially for its use as a promising clinical measure.
PubMed: 36950808
DOI: 10.7874/jao.2022.00472 -
Journal of Neurophysiology Nov 2017Dexterous manipulation relies on the ability to modulate grasp forces to variable digit position. However, the sensorimotor mechanisms underlying such critical ability...
Dexterous manipulation relies on the ability to modulate grasp forces to variable digit position. However, the sensorimotor mechanisms underlying such critical ability are not well understood. The present study addressed whether digit force-to-position modulation relies entirely on feedback of digit placement and force, or on the integration of such feedback with motor commands responsible for digit positioning. In two experiments, we asked 25 subjects to estimate the index fingertip position relative to the thumb (perception test) or to grasp and lift an object with an asymmetrical mass distribution while preventing object roll (action test). Both tests were performed after subjects' digits were placed actively or passively at different distances (active and passive condition, respectively) and without visual feedback. Because motor commands for digit positioning would be integrated with position and force feedback in the active condition, we hypothesized this condition to be characterized by greater accuracy of digit position estimation and digit force-to-position modulation. Surprisingly, discrimination of digit position and force-to-position modulation was statistically indistinguishable in the active and passive conditions. We conclude that voluntary commands for digit positioning are not essential for accurate estimation of finger position or modulation of digit forces to variable digit position. Thus digit force-to-position modulation can be implemented by integrating sensory feedback of digit position and voluntary commands of digit force production following contact. This study was designed to understand the sensorimotor mechanisms underlying digit force-to-position modulation required for manipulation. Surprisingly, estimation of relative digit position and force-to-position modulation was accurate regardless of whether the digits were passively or actively positioned. Therefore, accurate estimation of digit position does not require an efference copy of active digit positioning, and the hypothesized advantage of active over passive movement on estimation of end-point position appears to be task and effector dependent.
Topics: Adult; Feedback, Physiological; Female; Fingers; Humans; Male; Pinch Strength; Psychomotor Performance; Sensorimotor Cortex
PubMed: 28835523
DOI: 10.1152/jn.00211.2017 -
Frontiers in Human Neuroscience 2018Previous functional magnetic resonance imaging (fMRI) studies have demonstrated digit somatotopy in primary somatosensory cortex (SI), and even shown that at high...
Previous functional magnetic resonance imaging (fMRI) studies have demonstrated digit somatotopy in primary somatosensory cortex (SI), and even shown that at high spatial resolution it is possible to resolve within-digit somatotopy. However, fMRI studies have failed to resolve the spatial organisation of digit representations in secondary somatosensory cortex (SII). One of the major limitations of high spatial resolution fMRI studies of the somatosensory system has been the long acquisition time needed to acquire slices spanning both SI and SII. Here, we exploit the increased blood oxygenation level dependent contrast of ultra-high-field (7 Tesla) fMRI and the use of multiband imaging to study the topographic organisation in SI and SII with high spatial resolution at the individual subject level. A total of = 6 subjects underwent vibrotactile stimulation of their face, hand digits and foot (body imaging) and their individual hand digits (digit mapping) for each left and right sides of the body. In addition, = 2 subjects participated only in the body imaging experiment on both their left and right sides. We show an orderly representation of the face, hand digits and foot in contralateral primary cortex in each individual subject. In SII, there is clear separation of the body areas of the face, hand and foot but the spatial organisation varies across individual subjects. However, separate representation of the individual digits of the hand in SII could not be resolved, even at the spatial resolution of 1.5 mm due to largely overlapping representations.
PubMed: 29950980
DOI: 10.3389/fnhum.2018.00235