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Lancet (London, England) Sep 2015Psoriasis is an immune-mediated, genetic disease manifesting in the skin or joints or both. A diverse team of clinicians with a range of expertise is often needed to... (Review)
Review
Psoriasis is an immune-mediated, genetic disease manifesting in the skin or joints or both. A diverse team of clinicians with a range of expertise is often needed to treat the disease. Psoriasis provides many challenges including high prevalence, chronicity, disfiguration, disability, and associated comorbidity. Understanding the role of immune function in psoriasis and the interplay between the innate and adaptive immune system has helped to manage this complex disease, which affects patients far beyond the skin. In this Seminar, we highlight the clinical diversity of psoriasis and associated comorbid diseases. We describe recent developments in psoriasis epidemiology, pathogenesis, and genetics to better understand present trends in psoriasis management. Our key objective is to raise awareness of the complexity of this multifaceted disease, the potential of state-of-the-art therapeutic approaches, and the need for early diagnosis and comprehensive management of patients with psoriasis.
Topics: Humans; Psoriasis
PubMed: 26025581
DOI: 10.1016/S0140-6736(14)61909-7 -
South African Family Practice :... Oct 2021Leprosy (Hansen's disease) can affect multiple organs and body structures. Skin signs are typically observed in the early phase of the disease, hence being the first... (Review)
Review
Leprosy (Hansen's disease) can affect multiple organs and body structures. Skin signs are typically observed in the early phase of the disease, hence being the first identifiable signs to propel clinical suspicion. Leprosy predominantly affects the skin and peripheral nerves. The disease has been documented many centuries preceding the biblical era. Over many decades, the classification of Hansen's disease has changed as modern medical science evolved. Patients with leprosy are usually subjected to discrimination, rejection from society and can suffer from social stigma, poor quality of life (QoL), low self-esteem and permanent disfigurements. Studies have shown that leprosy has a significant negative impact on the patients' QoL. Leprosy is often not suspected by practicing clinicians because it is no longer emphasised in the medical curricula. In modern years, attention has gradually shifted from leprosy to tuberculosis (TB) and human immunodeficiency virus (HIV).
Topics: Affect; Bible; Humans; Leprosy; Quality of Life; Social Stigma
PubMed: 34797098
DOI: 10.4102/safp.v63i1.5311 -
Physical Medicine and Rehabilitation... Nov 2022Burn injuries are often devastating and leave the victim suffering from lifelong sequelae. To optimize care, burn care begins at the time of injury at the start of burn... (Review)
Review
Burn injuries are often devastating and leave the victim suffering from lifelong sequelae. To optimize care, burn care begins at the time of injury at the start of burn shock and extends through discharge with interventions in scar care and advancements in mobility. There are many dressings that can be used to treat burn wounds, although no dressing can replace surgical excision. Early excision and wound closure with autografting is the "gold standard" of burn care. Burn wounds often result in scarring that can cause contracture, pain, and disfiguration. The members of the Physical Medicine and Rehab (PM&R) team are integral in improving the quality of life of burn patients during and following recovery. This article functions to provide a brief overview of the burn care to the nonburn specialized audience, discuss select advanced burn interventions, and provide an introduction to the role of PM&R in the life of a burn patient.
Topics: Bandages; Burns; Humans; Pain; Quality of Life
PubMed: 36243477
DOI: 10.1016/j.pmr.2022.07.001