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Digestive Endoscopy : Official Journal... May 2022
Topics: Diverticulum; Diverticulum, Esophageal; Esophageal Diseases; Humans; Pharynx; Zenker Diverticulum
PubMed: 34486771
DOI: 10.1111/den.14109 -
Journal of Gastrointestinal and Liver... Sep 2019Gut microbiota composition and functionality are involved in the pathophysiology of several intestinal and extraintestinal diseases, and are increasingly considered a... (Review)
Review
Gut microbiota composition and functionality are involved in the pathophysiology of several intestinal and extraintestinal diseases, and are increasingly considered a modulator of local and systemic inflammation. However, the involvement of gut microbiota in diverticulosis and in diverticular disease is still poorly investigated. In this review, we critically analyze the existing evidence on the fecal and mucosa-associated microbiota composition and functionality across different stages of diverticular disease. We also explore the influence of risk factors for diverticulosis on gut microbiota composition, and speculate on the possible relevance of these associations for the pathogenesis of diverticula. We overview the current treatments of diverticular disease targeting the intestinal microbiome, highlighting the current areas of uncertainty and the need for future studies. Although no conclusive remarks on the relationship between microbiota and diverticular disease can be made, preliminary data suggest that abdominal symptoms are associated with reduced representation of taxa with a possible anti-inflammatory effect, such as Clostridium cluster IV, and overgrowth of Enterobacteriaceae, Bifidobacteria and Akkermansia. The role of the microbiota in the early stages of the disease is still very uncertain. Future studies should help to disentangle the role of the microbiome in the pathogenesis of diverticular disease and its progression towards more severe forms.
Topics: Animals; Bacteria; Diverticulitis; Diverticulum; Dysbiosis; Feces; Gastrointestinal Microbiome; Host-Pathogen Interactions; Humans; Intestinal Mucosa; Risk Factors
PubMed: 31517330
DOI: 10.15403/jgld-277 -
Medicina 2020
Topics: Diverticulum; Humans
PubMed: 32841144
DOI: No ID Found -
Therapeutische Umschau. Revue... Apr 2022Update Esophageal Diverticula Esophageal diverticula are rare diseases typically associated pathophysiologically with esophageal dysmotility. The most common location...
Update Esophageal Diverticula Esophageal diverticula are rare diseases typically associated pathophysiologically with esophageal dysmotility. The most common location (about 80%) is pharyngo-oesophageal. The therapy must be adapted to the location, the size, the symptoms and also the individual perioperative risk of the patient. In this context, following Herbella et al. [1] summarize that a) asymptomatic diverticula do not require therapy; b) small (< 1cm) diverticula do not usually need to be resected; c) medium-sized (1-3cm) and large (> 4cm) diverticula should be treated either by resection, pex, invagination or (for Zenker's diverticulum) by transoral diverticulo-esophagostomy, and d) a simultaneous myotomy should always be performed. Due to the rarity of esophageal diverticula and due to the wide range of therapeutic options, the expertise required for an individual therapy concept is often not available even in larger clinics, which is why we recommend treatment in a reference center. In our opinion, the counseling and treatment of patients with esophageal diverticula by an experienced interdisciplinary team using all the options of today's established endoscopic and surgical procedures is the prerequisite for a low-complication management of this unusual clinical picture.
Topics: Diverticulum; Diverticulum, Esophageal; Humans; Zenker Diverticulum
PubMed: 35440198
DOI: 10.1024/0040-5930/a001340 -
Gastroenterologia Y Hepatologia Feb 2019
Topics: Diverticulum; Duodenal Diseases; Humans; Jaundice, Obstructive; Magnetic Resonance Imaging; Male; Middle Aged; Syndrome
PubMed: 30122345
DOI: 10.1016/j.gastrohep.2018.07.009 -
Journal of Gastrointestinal Surgery :... Jan 2023
Topics: Humans; Diverticulum, Stomach; Gastric Mucosa; Meckel Diverticulum; Diverticulum
PubMed: 36127556
DOI: 10.1007/s11605-022-05464-0 -
Clinical Gastroenterology and... Dec 2018
Topics: Diverticulosis, Colonic; Diverticulum, Colon; Gastrointestinal Diseases; Humans; Inflammation
PubMed: 30454934
DOI: 10.1016/j.cgh.2018.07.023 -
International Journal of Colorectal... Sep 2023There is a hypothesis of an association between diverticulosis and metabolic syndrome (MS) or its components, but data on this topic are inconsistent, and a systematic... (Review)
Review
BACKGROUND
There is a hypothesis of an association between diverticulosis and metabolic syndrome (MS) or its components, but data on this topic are inconsistent, and a systematic review has not been performed. We conducted a systematic review to investigate the possible association between cardiometabolic risk factors and diverticulosis.
METHODS
A systematic literature search was conducted via PubMed, Cochrane Library, and Web of Science in December 2022 to collect the necessary data. Studies that examined the association between MS or individual metabolic factors and asymptomatic diverticulosis were included in the review.
RESULTS
Of the potentially relevant articles identified via PubMed (477), Cochrane Library (224), and Web of Science (296), 29 articles met the inclusion criteria and were used for this work. These studies were assessed for study quality using GRADE. Overall, 6 studies were rated as "very low," 19 studies as "low," and 4 studies as "moderate." The data suggest an association between arterial hypertension, obesity, and fatty liver disease in younger patients and diverticulosis. Patient age appears to play an important role in diverticular formation. Data on diabetes mellitus is inconclusive and may require further investigation depending on the location of the diverticula.
CONCLUSION
Based on the synthesized data, there is an association between arterial hypertension, obesity, and fatty liver disease in younger patients. The formation of diverticula seems to be influenced by age and genetic factors. The study suggests a connection with cardiometabolic risk factors. To gain a better understanding of the role of metabolic risk factors in asymptomatic diverticulosis, targeted studies are necessary based on these findings.
Topics: Humans; Diverticulum; Hypertension; Obesity; Risk Factors; Liver Diseases
PubMed: 37725283
DOI: 10.1007/s00384-023-04532-4 -
RoFo : Fortschritte Auf Dem Gebiete Der... Sep 2020
Topics: Abdomen, Acute; Aged; Anastomosis, Surgical; Diagnosis, Differential; Diverticulitis; Diverticulum; Humans; Ileus; Intestinal Perforation; Intestine, Small; Jejunal Diseases; Jejunum; Laparotomy; Male; Peritonitis; Tomography, X-Ray Computed
PubMed: 32674196
DOI: 10.1055/a-1157-9506 -
Clinical Gastroenterology and... Dec 2023
Topics: Humans; Hemorrhoids; Artifacts; Diverticulum; Gastrointestinal Hemorrhage
PubMed: 37031714
DOI: 10.1016/j.cgh.2023.03.038