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Biological Psychology Oct 2020Two independent lines of evidence suggest that drowsiness and mind-wandering share common neurocognitive processes indexed by ocular parameters (e.g., eyeblink frequency...
Two independent lines of evidence suggest that drowsiness and mind-wandering share common neurocognitive processes indexed by ocular parameters (e.g., eyeblink frequency and pupil dynamics). Mind-wandering and drowsiness frequently co-occur, however, such that it remains unclear whether observed oculometric variations are related to mind-wandering, drowsiness, or a mix of both. To address this issue, we assessed fluctuations in mind-wandering and sleepiness during a sustained attention task while ocular parameters were recorded. Results showed that oculometric variations during mind-wandering were fully explained by increased sleepiness. However, mind-wandering and sleepiness had additive deleterious effects on performance that were not fully explained by ocular parameters. These findings suggest that oculometric variations during task performance reflect increased drowsiness rather than processes specifically involved in mind-wandering, and that the neurocognitive processes indexed by oculometric parameters (e.g., regulatory processes of the locus coeruleus norepinephrine system) do not fully explain how mind-wandering and sleepiness cause attentional lapses.
Topics: Attention; Humans; Pupil; Sleepiness; Task Performance and Analysis
PubMed: 32871227
DOI: 10.1016/j.biopsycho.2020.107950 -
Sleep Medicine Clinics Dec 2019Sleepiness remains a major contributor to road crashes. Driver monitoring systems identify early signs of sleepiness and alert drivers, using real-time analysis of... (Review)
Review
Sleepiness remains a major contributor to road crashes. Driver monitoring systems identify early signs of sleepiness and alert drivers, using real-time analysis of eyelid movements, EEG activity, and steering control. Other vehicle adaptations warn drivers of lane departures or collision hazards, with higher vehicle automation actively taking over vehicle control to prevent run off the road incidents and institute emergency braking. Similarly, road adaptations warn drivers (rumble strips) or mitigate crash severity (barriers). Infrastructure to encourage drivers to use countermeasures, such as rest stops for napping, is also important. The effectiveness of adaptations varies for different road users.
Topics: Accidents, Traffic; Automobile Driving; Humans; Sleepiness
PubMed: 31640876
DOI: 10.1016/j.jsmc.2019.08.005 -
International Journal of Environmental... Dec 2021Since seafarers are known to be exposed to numerous job-related stress factors that can cause fatigue, sleepiness, and disturbed sleep behaviour, the aim of this review... (Review)
Review
Since seafarers are known to be exposed to numerous job-related stress factors that can cause fatigue, sleepiness, and disturbed sleep behaviour, the aim of this review was to provide an overview of the subjective and objective measurement methods of these strains. Using a systematic review, 166 studies were identified within the period of January 2010 to December 2020 using the PubMed database. Of the 21 studies selected, 13 used both subjective and objective measurement methods. Six studies used only subjective and two studies only objective methods. For subjective assessment, 12 different questionnaires could be identified as well as activity and sleeping logs. Actigraphy and reaction time tests (RTT) were the most common objective methods. In single cases, electrooculography (EOG), pupillometry and ambulatory polysomnography (PSG) were used. Measurement-related limitations due to vessel-related impacts were less often reported than expected. No restrictions of daily routines on board were described, and only single-measurement disturbances due to ship movements were mentioned. The present literature review reveals that there are various routines to measure fatigue, sleepiness, and sleep behaviour on board. A combination of subjective and objective methods often appears to be beneficial. The frequent use of actigraphy and RTT on board suggests good feasibility and reliable measurements with these methods. The use of ambulatory PSG in maritime-like contexts suggests that this method would also be feasible on board.
Topics: Fatigue; Humans; Ships; Sleep; Sleepiness; Surveys and Questionnaires; Wakefulness
PubMed: 35010383
DOI: 10.3390/ijerph19010120 -
Environment International Jun 2020To investigate whether exposure to dampness and mold at home and at work induce sleep disturbances and daytime sleepiness among adults.
AIM
To investigate whether exposure to dampness and mold at home and at work induce sleep disturbances and daytime sleepiness among adults.
MATERIALS AND METHODS
Associations between onset of sleep disturbances and dampness, mold and mold odor at home and at work were investigated in a cohort of 11,318 adults from the population in Iceland, Norway, Sweden, Denmark and Estonia. The participants answered a questionnaire at baseline and 10 years later, with questions on sleep disturbances, including difficulty initiating sleep (DIS), difficulty maintaining sleep (DMS), early morning awakening (EMA), insomnia symptoms, snoring and excessive daytime sleepiness (EDS). Multiple logistic regression models were applied to estimate associations adjusting for potential confounders including gender, age, smoking habit at baseline, change of smoking habit from baseline to follow up, BMI at baseline, change of BMI from baseline to follow up, education level at follow up, allergic rhinitis at baseline, doctor diagnosed asthma at baseline and chronic bronchitis at baseline.
RESULTS
Baseline floor dampness, visible mold and mold odor at home increased onset of DIS, DMS, EMA, insomnia symptoms and snoring during follow up (OR 1.29-1.87). Any sign of dampness at baseline increased onset of DIS (OR 1.28, 95%CI 1.06-1.55), DMS (OR 1.17, 95%CI 1.02-1.34) and insomnia symptoms (OR 1.18, 95%CI 1.03-1.36). Dampness at home during follow up increased onset of DIS, DMS, EMA, insomnia symptoms and EDS (OR 1.17-1.36). Dampness at work during follow up increased onset of DIS, EMA, insomnia symptoms and EDS (OR 1.16-1.34). Combined dampness at home and at work during follow up increased the risk of onset of DIS, DMS, EMA, insomnia symptoms and EDS (OR 1.29-1.74).
CONCLUSIONS
Dampness and mold at home and at work can increase the development of insomnia symptoms, snoring and EDS among adults.
Topics: Adult; Humans; Norway; Sleep Initiation and Maintenance Disorders; Sleepiness; Snoring; Surveys and Questionnaires; Sweden
PubMed: 32272294
DOI: 10.1016/j.envint.2020.105691 -
Epilepsy & Behavior : E&B Sep 2022Lacosamide (LCM), is a third-generation antiseizure medicine, with limited clinical evidence for use in pediatric populations. We aimed to evaluate evidence for the... (Meta-Analysis)
Meta-Analysis Review
OBJECTIVE
Lacosamide (LCM), is a third-generation antiseizure medicine, with limited clinical evidence for use in pediatric populations. We aimed to evaluate evidence for the efficacy and safety of LCM in pediatric patients with epilepsy.
METHODS
A systematic review was performed using literature published from inception to February 2022 identified in MEDLINE, Embase, Cochrane Library, and four Chinese databases. Efficacy and safety outcome data were collected, and a meta-analysis was performed.
RESULT
Twenty-one studies involving 1230 pediatric patients were included. The median percent reduction in seizure frequency per 28 days from baseline to maintenance was 33.1% (95% confidence interval [CI] 22.7%, 43.5%). After 6 months of treatment, the 50%, 75%, and 100% responder rates were 53.3% (95% CI 40.7%, 65.9%), 28.3% (95% CI 20.8%, 35.8%), and 20.4% (95% CI 12.6%, 28.2%), respectively. After 12 months of treatment, the 50%, 75%, and 100% responder rates were 42.0% (95% CI 29.5%, 54.5%), 19.5% (95% CI 11.1%, 27.8%), and 15.2% (95% CI 6.6%, 23.8%), respectively. The most common adverse events (AEs) were drowsiness (15.0%), dizziness (9.9%), and somnolence (8.3%).
CONCLUSION
Lacosamide is generally effective and well tolerated to use in children with epilepsy. However, further research with high-quality data and long-term follow-up of LCM use in pediatric populations is needed.
Topics: Anticonvulsants; Child; Epilepsies, Partial; Epilepsy; Humans; Lacosamide; Sleepiness; Treatment Outcome
PubMed: 35914435
DOI: 10.1016/j.yebeh.2022.108781 -
Journal of Clinical Sleep Medicine :... Oct 2022Obstructive sleep apnea (OSA) is a common, identifiable, and treatable disorder with serious health, safety, and financial implications-including sleepiness- related...
UNLABELLED
Obstructive sleep apnea (OSA) is a common, identifiable, and treatable disorder with serious health, safety, and financial implications-including sleepiness- related crashes and incidents-in workers who perform safety-sensitive functions in the transportation industry. Up to one-third of crashes of large trucks are attributable to sleepiness, and large truck crashes result in more than 4,000 deaths annually. For each occupant of a truck who is killed, 6 to 7 occupants of other vehicles are killed. Treatment of OSA is cost-effective, lowers crash rates, and improves health and well-being. A large body of scientific evidence and expert consensus supports the identification and treatment of OSA in transportation operators. An Advanced Notice of Proposed Rulemaking regarding the diagnosis and treatment of OSA in commercial truck and rail operators was issued by the Federal Motor Carrier Safety Administration and Federal Railroad Administration, but it was later withdrawn. This reversal of the agencies' position has caused confusion among some, who have questioned whether efforts to identify and treat the disorder are warranted. In response, we urge key stakeholders, including employers, operators, legislators, payers, clinicians, and patients, to engage in a collaborative, patient-centered approach to address the disorder. At a minimum, stakeholders should follow the guidelines issued by a medical review board commissioned by the Federal Motor Carrier Safety Administration in 2016 alone, or in combination with the 2006 criteria, "Sleep Apnea and Commercial Motor Vehicle Operators," a Statement from the Joint Task Force of the American College of Chest Physicians, the American College of Occupational and Environmental Medicine, and the National Sleep Foundation developed by a joint task force. As research in this area continues to evolve, waiting is no longer an option, and the current standard of care demands action to mitigate the burden of serious health and safety risks due to this common, treatable disorder.
CITATION
Das AM, Chang JL, Berneking M, Hartenbaum NP, Rosekind M, Gurubhagavatula I. Obstructive sleep apnea screening, diagnosis, and treatment in the transportation industry. 2022;18(10):2471-2479.
Topics: Accidents, Traffic; Automobile Driving; Humans; Risk Factors; Sleep Apnea, Obstructive; Sleepiness
PubMed: 34546916
DOI: 10.5664/jcsm.9672 -
Psychophysiology Aug 2021We systematically examined the temporal relationships between subjective sleepiness and both physiological drowsiness and performance impairment in a controlled...
We systematically examined the temporal relationships between subjective sleepiness and both physiological drowsiness and performance impairment in a controlled laboratory setting. Eighteen healthy young adults (8 women; M = 21.44 ± 3.24 years) underwent 40 hr of extended wakefulness, completing a bihourly Karolinska Sleepiness Scale (KSS) and 10-min Psychomotor Vigilance Task (PVT). Microsleeps and slow eye movements (SEMs) were scored during the PVT. KSS scores increased 3 hr prior to performance impairment (p < .001) and 4-6 hr prior to physiological sleepiness (p < .001). There were strong within-subject correlations between KSS and PVT lapses (r = 0.75, p < .001) and physiological drowsiness (r > 0.60, p < .001). Between-subjects product-moment correlations were more modest but showed a significant positive increase across time awake, suggesting that subjective sleepiness and objective outcomes were more tightly correlated after sleep loss. Cross-correlations showed significant positive correlations at 0-lag (p < .034); however, a high proportion of participants showed maximal correlations at positive lags, suggesting KSS was associated with future objective impairment. Within individuals, subjective sleepiness was highly correlated with objective impairment, between-subject correlations were more modest, possibly due to interindividual vulnerability to sleep loss. These results suggest that subjective sleepiness represents an inbuilt early warning system for subsequent drowsiness and performance impairment.
Topics: Adolescent; Adult; Arousal; Awareness; Female; Humans; Male; Psychomotor Performance; Sleepiness; Time Factors; Young Adult
PubMed: 34032305
DOI: 10.1111/psyp.13839 -
Sleep Medicine Clinics Dec 2019Sleepiness accounts for approximately 20% of major highway motor vehicle accidents (MVAs) and the most common medical disorder associated with sleepiness is obstructive... (Review)
Review
Sleepiness accounts for approximately 20% of major highway motor vehicle accidents (MVAs) and the most common medical disorder associated with sleepiness is obstructive sleep apnea (OSA). OSA patients are 2 to 3 times more likely to have an MVA than the general population, although continuous positive airway pressure therapy can remove this excess risk. Several jurisdictions have introduced regulations to limit driving in patients with moderate or severe OSA associated with sleepiness until the disorder is effectively treated. Successful implementation of such regulations requires education regarding risk-benefit relationships of relevant stakeholders, including patients, clinicians, and employers in the transportation industry.
Topics: Accidents, Traffic; Automobile Driving; Continuous Positive Airway Pressure; Humans; Sleep Apnea, Obstructive; Sleepiness
PubMed: 31640877
DOI: 10.1016/j.jsmc.2019.08.006 -
Chronobiology International Mar 2022Sleep is an essential component of the daily cycle. Age and puberty-related declines in sleep duration, delays in chronotype, and an increase in social jet lag have been...
Sleep is an essential component of the daily cycle. Age and puberty-related declines in sleep duration, delays in chronotype, and an increase in social jet lag have been consistently reported. This study examined chronotype and gender-based differences in adolescents' sleep quality, depression level, and academic achievements. Eight hundred fifteen school students (372 male and 443 female) aged 14 to 20 years voluntarily participated in this study. Horne and Östberg Morningness-Eveningness Questionnaire (MEQ) was used to measure their chronotype. Sleep duration, sleep quality, and daytime sleepiness were assessed by the Pediatric Daytime Sleepiness Scale (PDSS) and Epworth Sleepiness Scale (ESS). Pittsburghs Sleep Quality Index (PSQI) was used to evaluate sleep habits. Cleveland Adolescent Sleepiness Questionnaire (CASQ) was used to measure the sleep pattern of the students. Zung Self-Rating Depression Scale (SDS) was used to assess the level of depression for the students. Our results show neither type of students dominated the population studied but interestingly, in comparison to evening type, morning type individuals were higher among the population. Chronotype-based sleep quality and academic performances were observed, and higher depression levels, poor sleep quality, poor academic performances were observed in evening type compared to neither type and morning type. In contrast to males, females had a poor sleep pattern (CASQ) and a higher depression level (SDS). Altogether, our study shows the effect of chronotype and gender on sleep quality and depression levels among school students.
Topics: Academic Performance; Adolescent; Child; Circadian Rhythm; Disorders of Excessive Somnolence; Female; Humans; Male; Sleep; Sleep Quality; Sleepiness; Students; Surveys and Questionnaires
PubMed: 34794352
DOI: 10.1080/07420528.2021.2002350 -
Journal of Clinical Sleep Medicine :... Sep 2019Drowsiness leads to 20% of fatal road crashes, while inability to assess drowsiness has hampered drowsiness interventions. This study examined the accuracy of eye-blink... (Randomized Controlled Trial)
Randomized Controlled Trial
STUDY OBJECTIVES
Drowsiness leads to 20% of fatal road crashes, while inability to assess drowsiness has hampered drowsiness interventions. This study examined the accuracy of eye-blink parameters for detecting drowsiness related driving impairment in real time.
METHODS
Twelve participants undertook two sessions of 2-hour track-driving in an instrumented vehicle following a normal night's sleep or 32 to 34 hours of extended wake in a randomized crossover design. Eye-blink parameters and lane excursion events were monitored continuously.
RESULTS
Sleep deprivation increased the rates of out-of-lane driving events and early drive terminations. Episodes of prolonged eyelid closures, blink duration, the ratio of amplitude to velocity of eyelid closure, and John's Drowsiness Score (JDS, a composite score) were also increased following sleep deprivation. A time-on-task (drive duration) effect was evident for out-of-lane events rate and most eye-blink parameters after sleep deprivation. The JDS demonstrated the strongest association with the odds of out-of-lane events in the same minute, whereas measures of blink duration and prolonged eye closure were stronger indicators of risk for out-of-lane events over longer periods of 5 minutes and 15 minutes, respectively. Eye-blink parameters also achieved moderate accuracies (specificities from 70.12% to 84.15% at a sensitivity of 50%) for detecting out-of-lane events in the same minute, with stronger associations over longer timeframes of 5 minutes to 15 minutes.
CONCLUSIONS
Eyelid closure parameters are useful tools for monitoring and predicting drowsiness-related driving impairment (out-of-lane events) that could be utilized for monitoring drowsiness and assessing the efficacy of drowsiness interventions.
CLINICAL TRIAL REGISTRATION
This study is registered with the Australian New Zealand Clinical Trial Registry (ANCTR), http://www.anzctr.org.au/TrialSearch.aspx ACTRN12612000102875.
CITATION
Shekari Soleimanloo S, Wilkinson VE, Cori JM,Westlake J, Stevens B, Downey LA, Shiferaw BA, Rajaratnam SMW, Howard ME. Eye-blink parameters detect on-road track-driving impairment following severe sleep deprivation. J Clin Sleep Med. 2019;15(9):1271-1284.
Topics: Adult; Australia; Automobile Driving; Blinking; Cross-Over Studies; Disorders of Excessive Somnolence; Female; Humans; Male; Reaction Time; Reproducibility of Results; Sleep Deprivation; Sleepiness
PubMed: 31538598
DOI: 10.5664/jcsm.7918