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Ugeskrift For Laeger Mar 2018
Topics: Denmark; Humans; Precision Medicine
PubMed: 29559072
DOI: No ID Found -
Ugeskrift For Laeger Jun 2018
Topics: Humans; Precision Medicine; United States; United States Food and Drug Administration
PubMed: 29886885
DOI: No ID Found -
The Yale Journal of Biology and Medicine Sep 2017Comparative Medicine is typically defined as a discipline which relates and leverages the biological similarities and differences among animal species to better... (Review)
Review
Comparative Medicine is typically defined as a discipline which relates and leverages the biological similarities and differences among animal species to better understand the mechanism of human and animal disease. It has also been defined as a field of study concentrating on similarities and differences between human and veterinary medicine and is increasingly associated with animal models of human disease, including the critical role veterinarians, animal resource centers, and Institutional Animal Care and Use Committees play in facilitating and ensuring humane and reproducible laboratory animal care and use. To this end, comparative medicine plays a pivotal role in reduction, refinement, and replacement in animals in biomedical research. On many levels, comparative medicine facilitates the translation of basic science knowledge into clinical applications; applying comparative medicine concepts throughout the translation process is critical for success. In addition to the supportive role of comparative medicine in the research enterprise, its role as a distinct and independent scientific discipline should not be lost. Although comparative medicine's research "niche" is not one particular discipline or disease process, rather, it is the investigative mindset that seeks to reveal common threads that weave different pathophysiologic processes into translatable approaches and outcomes using various models.
Topics: Animals; Animals, Laboratory; Biomedical Research; Humans; Medicine; Translational Research, Biomedical; Veterinarians
PubMed: 28955187
DOI: No ID Found -
Radiologia 2020
Topics: Nuclear Medicine
PubMed: 32475611
DOI: 10.1016/j.rx.2020.04.003 -
Sleep Medicine Clinics Sep 2020Telemedicine is about more than simply using audio-visual technology to care for patients, but rather an opportunity to fundamentally improve patient access, quality,... (Review)
Review
Telemedicine is about more than simply using audio-visual technology to care for patients, but rather an opportunity to fundamentally improve patient access, quality, efficiencies, and experience. Regarding sleep medicine, it has the potential to drive sleep medicine's evolution. By enabling care across geographies and facilitating population-based management, sleep medicine is poised to take advantage of telemedicine capabilities. In this introductory chapter, we highlight issues related to sleep telemedicine, while providing a framework in which to approach this transformational journey thoughtfully. We thereby set the stage for the individual chapters in this edition of Sleep Medicine Clinics.
Topics: Humans; Quality of Health Care; Sleep Wake Disorders; Telemedicine
PubMed: 32762967
DOI: 10.1016/j.jsmc.2020.05.005 -
Lakartidningen May 2018
Topics: Biomedical Research; Evidence-Based Medicine; Humans; Meta-Analysis as Topic; Systematic Reviews as Topic
PubMed: 29809269
DOI: No ID Found -
JAMA Pediatrics Nov 2017
Topics: Attitude of Health Personnel; Attitude to Death; Child; Humans; Medicine; Physician-Patient Relations; Physicians
PubMed: 28873122
DOI: 10.1001/jamapediatrics.2017.2235 -
Journal of Cell Science Jan 2022Current medicine has only taken us so far in reducing disease and tissue damage. Extracellular vesicles (EVs), which are membranous nanostructures produced naturally by... (Review)
Review
Current medicine has only taken us so far in reducing disease and tissue damage. Extracellular vesicles (EVs), which are membranous nanostructures produced naturally by cells, have been hailed as a next-generation medicine. EVs deliver various biomolecules, including proteins, lipids and nucleic acids, which can influence the behaviour of specific target cells. Since EVs not only mirror composition of their parent cells but also modify the recipient cells, they can be used in three key areas of medicine: regenerative medicine, disease detection and drug delivery. In this Review, we discuss the transformational and translational progress witnessed in EV-based medicine to date, focusing on two key elements: the mechanisms by which EVs aid tissue repair (for example, skin and bone tissue regeneration) and the potential of EVs to detect diseases at an early stage with high sensitivity and specificity (for example, detection of glioblastoma). Furthermore, we describe the progress and results of clinical trials of EVs and demonstrate the benefits of EVs when compared with traditional medicine, including cell therapy in regenerative medicine and solid biopsy in disease detection. Finally, we present the challenges, opportunities and regulatory framework confronting the clinical application of EV-based products.
Topics: Extracellular Vesicles; Proteins; Regenerative Medicine; Wound Healing
PubMed: 35019142
DOI: 10.1242/jcs.259166 -
Lakartidningen May 2021Complex diseases represent a number of common disorders such as allergic conditions, cardiovascular, metabolic and chronic inflammatory diseases. These diseases are... (Review)
Review
Complex diseases represent a number of common disorders such as allergic conditions, cardiovascular, metabolic and chronic inflammatory diseases. These diseases are caused by a combination of genetic, environmental and lifestyle factors. This complex etiology creates challenges when it comes to diagnostics, follow-up programs and treatment. Although exact disease mechanisms are yet to be elucidated for most complex diseases, key genetic determinants have been mapped and omics profiling has unraveled involved pathways. Using this wealth of data, precision medicine applications have started to appear also for common, complex diseases. In this article, we review current precision medicine applications from a clinical point of view and outline briefly a roadmap ahead for further clinical implementation of precision medicine in complex diseases.
Topics: Chronic Disease; Humans; Precision Medicine
PubMed: 33977516
DOI: No ID Found -
Emerging Topics in Life Sciences Oct 2021This special issue of Emerging Topics in Life Sciences entitled 'Current Topics in Stem Cells and Regenerative Medicine' brings together expertise from a collaborative...
This special issue of Emerging Topics in Life Sciences entitled 'Current Topics in Stem Cells and Regenerative Medicine' brings together expertise from a collaborative organisation known as the Mercia Stem Cell Alliance (MSCA). The alliance was established initially by Professors Sue Kimber (University of Manchester) and Jon Frampton (University of Birmingham) just over 10 years ago and now has multiple regional centres of excellence across the Midlands and North West of the UK, including Aston University, University of Chester, Keele University, Manchester Metropolitan University, Lancaster University, University of Leicester, University of Liverpool, Liverpool John Moore's University, Loughborough University, University of Nottingham, University of Oxford, University of Sheffield, University of York. Many of these centres have contributed reviews to this issue. The MSCA also partners with industrial and clinical organisations, including the NHS, and is active in bringing stem cells and regenerative medicines to a meaningful translational endpoint (see: http://www.msca.manchester.ac.uk/).
Topics: Humans; Regenerative Medicine; Stem Cells; United Kingdom
PubMed: 34636399
DOI: 10.1042/ETLS20210264