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The Journal of Dermatological Treatment Nov 2022Microwaves are used in medicine for diagnostics, and treatment of cancer. Recently, novel microwave devices (Swift, Emblation Ltd, UK and miraDry, Miramar Labs Inc., CA)... (Review)
Review
BACKGROUND
Microwaves are used in medicine for diagnostics, and treatment of cancer. Recently, novel microwave devices (Swift, Emblation Ltd, UK and miraDry, Miramar Labs Inc., CA) have been cleared by the FDA and Health Canada for various dermatological conditions.
OBJECTIVE AND METHODS
To review the dermatological use of microwave-based treatments (plantar warts, corns, actinic keratosis, dermatophytosis, axillary hyperhidrosis, osmidrosis, and hidradenitis suppurativa). Clinical trials, case reports, or studies for each condition are summarized.
RESULTS AND CONCLUSION
Microwaves are a promising alternative therapy for cutaneous warts, actinic keratosis, axillary hyperhidrosis, and osmidrosis, with favorable safety profiles. However, patients with hidradenitis suppurativa have had negative clinical outcomes. Limited treatment of corns showed good pain reduction but did not resolve hyperkeratosis. A preliminary study indicated that microwave treatment inhibits the growth of . We present the first case of toenail onychomycosis successfully treated with microwaves. Despite the advancements in the use of microwaves, the mechanism of action in non-ablative treatment is not well understood; further research is needed. More high-quality randomized clinical trials with larger groups and long follow-up periods are also required to evaluate the clinical benefits and possible adverse effects of microwaves in treating dermatological conditions.
Topics: Humans; Microwaves; Hidradenitis Suppurativa; Keratosis, Actinic; Callosities; Dermatology; Hyperhidrosis; Warts; Sweat Gland Diseases; Technology; Treatment Outcome
PubMed: 35699665
DOI: 10.1080/09546634.2022.2089333 -
Gan To Kagaku Ryoho. Cancer &... Jul 2015There are 2 types of regional therapy for hepatocellular carcinoma(HCC). One is transarterial therapy based on the dual supply of hepatic blood flow and characteristics... (Review)
Review
There are 2 types of regional therapy for hepatocellular carcinoma(HCC). One is transarterial therapy based on the dual supply of hepatic blood flow and characteristics of hypervascular tumors, and the other is local puncture or ablation therapy using a needle or an electric pole. The latter type of therapy is based on the macroscopic form of HCC, which is localized and nodular. With regard to transarterial therapies, hepatic arterial infusion(HA), ligation of hepatic arteries(dearterialization), and transarterial chemoembolization(TACE)have been developed and improved. At present, TACE with Lipiodol(Lip-TACE) is a first-line therapy for locally advanced HCC. Moreover, with regard to local puncture or ablation therapies, percutaneous ethanol injection(PEI)and microwave coagulation therapy(MCT)-both of which originated in Japan-as well as radiofrequency ablation(RFA)have been developed and improved. At present, the first-line local ablation therapy for relatively earlystage HCC(3 cm or less in diameter and 3 or less tumors)is RFA. A RCT is underway to compare the long-term prognosis of patients with HCC between hepatic resection and RFA.
Topics: Carcinoma, Hepatocellular; Catheter Ablation; Chemoembolization, Therapeutic; Hepatic Artery; Humans; Liver Neoplasms; Microwaves
PubMed: 26197736
DOI: No ID Found -
American Journal of Clinical Dermatology Apr 2020Hidradenitis suppurativa is a chronic inflammatory skin disease characterized by inflammatory nodules, abscesses, and sinus tracts in intertriginous areas that has a... (Review)
Review
Hidradenitis suppurativa is a chronic inflammatory skin disease characterized by inflammatory nodules, abscesses, and sinus tracts in intertriginous areas that has a significant impact on patient quality of life. Treatments range from topical, intralesional, systemic, and surgical. Furthermore, laser and light-based treatment options have become increasingly popular because of the limitations of adverse effects associated with systemic therapy and decreased down-time associated with laser and light therapy. These modalities are thought to work through a variety of mechanisms including decreasing inflammation, destroying hair follicles, targeting sebaceous glands, killing bacteria, and debulking lesions through ablation. This review explores these laser and light-based treatment modalities for the treatment of hidradenitis suppurativa.
Topics: Hidradenitis Suppurativa; Humans; Intense Pulsed Light Therapy; Laser Therapy; Microwaves; Photochemotherapy; Radiofrequency Therapy
PubMed: 31845121
DOI: 10.1007/s40257-019-00491-1 -
The Journal of Dermatological Treatment May 2022Axillary hyperhidrosis and bromhidrosis have serious social, emotional, and professional consequences. There are several treatments of axillary hyperhidrosis. We present...
INTRODUCTION
Axillary hyperhidrosis and bromhidrosis have serious social, emotional, and professional consequences. There are several treatments of axillary hyperhidrosis. We present a case series evaluating the efficacy and safety of microwave device for axillary hyperhidrosis and bromhidrosis.
MATERIALS AND METHODS
Seven patients were included in our case series. Four patients had both hyperhidrosis and bromhidrosis. Three patients had only hyperhidrosis. To evaluate the degree of hyperhidrosis and degree bromhidrosis a self-reported Hyperhidrosis Disease Severity Scale (HDSS) score and 4-point malodor grade were assessed. All patients underwent 1 or 2 microwave treatments. Patients underwent a survey on treatment outcomes and adverse effect conducted through telephone 12 months after their last procedure.
RESULTS
Six of seven patients had a 2-point drop in HDSS score. The four patients with bromhidrosis had a 2-point drop on the self-reported malodor measurement 12 months post treatment. Minor adverse effects related to the therapy occurred.
CONCLUSION
This novel microwave-based treatment was effective for the treatment of axillary hyperhidrosis and bromhidrosis. Patient satisfaction with the procedure is high, and adverse events are typically transient and well tolerated.
Topics: Axilla; Body Odor; Humans; Hyperhidrosis; Microwaves; Treatment Outcome
PubMed: 33622150
DOI: 10.1080/09546634.2020.1856317 -
International Urology and Nephrology Sep 2023Thermal ablation, including microwave ablation (MWA) and radiofrequency ablation (RFA), has been recommended for the treatment of primary hyperparathyroidism (PHPT) and... (Meta-Analysis)
Meta-Analysis Review
OBJECTIVE
Thermal ablation, including microwave ablation (MWA) and radiofrequency ablation (RFA), has been recommended for the treatment of primary hyperparathyroidism (PHPT) and refractory secondary hyperparathyroidism (SHPT). This meta-analysis was conducted to evaluate the efficacy and safety of MWA and RFA in patients with PHPT and refractory SHPT.
METHODS
Databases including PubMed, EMbase, the Cochrane Library, CNKI (China National Knowledge Infrastructure), and Wanfang were searched from inception to December 5, 2022. Eligible studies comparing MWA and RFA for PHPT and refractory SHPT were included. Data were analyzed using Review Manager software, version 5.3.
RESULTS
Five studies were included in the meta-analysis. Two were retrospective cohort studies, and three were RCTs. Overall, 294 patients were included in the MWA group, and 194 patients were included in the RFA group. Compared with RFA for refractory SHPT, MWA had a shorter operation time for a single lesion (P < 0.01) and a higher complete ablation rate for a single lesion ≥ 15 mm (P < 0.01) but did not show a difference in the complete ablation rate for a single lesion < 15 mm (P > 0.05). There were no significant differences between MWA and RFA for refractory SHPT concerning parathyroid hormone (P > 0.05), calcium (P > 0.05), and phosphorus levels (P > 0.05) within 12 months after ablation, except that calcium (P < 0.01) and phosphorus levels (P = 0.02) in the RFA group were lower than those in the MWA group at one month after ablation. There was no significant difference between MWA and RFA concerning the cure rate of PHPT (P > 0.05). There were no significant differences between MWA and RFA for PHPT and refractory SHPT concerning the complications of hoarseness (P > 0.05) and hypocalcaemia (P > 0.05).
CONCLUSION
MWA had a shorter operation time for single lesions and a higher complete ablation rate for large lesions in patients with refractory SHPT. However, there was no significant difference in efficacy and safety between MWA and RFA in cases of both PHPT and refractory SHPT. Both MWA and RFA are effective treatment methods for PHPT and refractory SHPT.
Topics: Humans; Calcium; Ablation Techniques; Retrospective Studies; Microwaves; Radiofrequency Ablation; Hyperparathyroidism, Secondary; Treatment Outcome; Phosphorus; Catheter Ablation
PubMed: 36892812
DOI: 10.1007/s11255-023-03543-y -
BioMed Research International 2018Uterine fibroids are the most common benign pelvic tumor of the female genital tract and tend to increase with age; they cause menorrhagia, dysmenorrhea, pelvic pressure... (Review)
Review
Uterine fibroids are the most common benign pelvic tumor of the female genital tract and tend to increase with age; they cause menorrhagia, dysmenorrhea, pelvic pressure symptoms, back pain, and subfertility. Currently, the management is based mainly on medical or surgical approaches. The nonsurgical and minimally invasive therapies are emerging approaches that to the state of the art include uterine artery embolization (UAE), image-guided thermal ablation techniques like magnetic resonance-guided focused ultrasound surgery (MRgFUS) or radiofrequency ablation (RF), and percutaneous microwave ablation (PMWA). The purpose of the present review is to describe feasibility results and safety of PMWA according to largest studies available in current literature. Moreover technical aspects of the procedure were analyzed providing important data on large scale about potential efficacy of PMWA in clinical setting. However larger studies with international registries and randomized, prospective trials are still needed to better demonstrate the expanding benefits of PMWA in the management of uterine fibroids.
Topics: Female; Humans; Leiomyoma; Magnetic Resonance Imaging; Microwaves; Pelvic Neoplasms; Pelvis; Radiofrequency Therapy; Radiotherapy, Image-Guided; Treatment Outcome; Uterine Artery Embolization
PubMed: 29511672
DOI: 10.1155/2018/2360107 -
Cellular & Molecular Immunology Sep 2021Surgery is essential for controlling the symptoms and complications of stage IV breast cancer. However, locoregional treatment of primary tumors often results in distant...
Surgery is essential for controlling the symptoms and complications of stage IV breast cancer. However, locoregional treatment of primary tumors often results in distant progression, including lung metastasis, the most common type of visceral metastasis. As a minimally invasive thermal therapy, microwave ablation (MWA) has been attempted in the treatment of breast cancer, but the innate immune response after MWA has not yet been reported. Using two murine models of stage IV breast cancer, we found that MWA of primary breast cancer inhibited the progression of lung metastasis and improved survival. NK cells were activated after MWA of the primary tumor and exhibited enhanced cytotoxic functions, and the cytotoxic pathways of NK cells were activated. Depletion experiments showed that NK cells but not CD4+ or CD8+ T cells played a pivotal role in prolonging survival. Then, we found that compared with surgery or control treatment, MWA of the primary tumor induced completely different NK-cell-related cytokine profiles. Macrophages were activated after MWA of the primary tumor and produced IL-15 that activated NK cells to inhibit the progression of metastasis. In addition, MWA of human breast cancer stimulated an autologous NK-cell response. These results demonstrate that MWA of the primary tumor in metastatic breast cancer inhibits metastatic progression via the macrophage/IL-15/NK-cell axis. MWA of the primary tumor may be a promising treatment strategy for de novo stage IV breast cancer, although further substantiation is essential for clinical testing.
Topics: Animals; Breast Neoplasms; CD8-Positive T-Lymphocytes; Female; Humans; Killer Cells, Natural; Mice; Microwaves; Radiofrequency Ablation; Treatment Outcome
PubMed: 32385362
DOI: 10.1038/s41423-020-0449-0 -
Endocrine Nov 2018To evaluate the effectiveness and safety of microwave ablation (MWA), including cooled MWA (cMWA) and uncooled MWA (uMWA), for the treatment of benign thyroid nodules... (Meta-Analysis)
Meta-Analysis Review
PURPOSE
To evaluate the effectiveness and safety of microwave ablation (MWA), including cooled MWA (cMWA) and uncooled MWA (uMWA), for the treatment of benign thyroid nodules (BTNs).
METHODS
The databases of MEDLINE, EMBASE and Cochrane library were searched up to 3 Jun, 2018. In this meta-analysis, data of volume reduction rates (VRRs) at the 3-, 6- and 12-month follow-up, and complications are obtained to evaluate the effectiveness and safety of cMWA and uMWA for the treatment of BTNs.
RESULTS
Nine studies involving 1461 patients with 1845 BTNs were included. The pooled VRR at the 3-month follow-up after MWA therapy reached 54.3% (95% CI: 45.3-63.3%, I = 97.6%), 73.5% (95% CI: 66.7-80.3%, I = 94.9%) at the 6-month follow-up, and 88.6% (95% CI: 84.9-92.4%, I = 92.7%) at the 12-month follow-up. The pooled proportions of overall, major and minor complications were 52.4% (95% CI: 29.8-74.9%; I = 99.5%), 4.8% (95% CI: 2.7-7.0%; I = 55.9%) and 48.3% (95% CI: 31.2-65.4%; I = 99.7%). Both cMWA and uMWA achieved similar pooled VRR at the 3-month follow-up (58.4 vs 45.3%, P = 0.07) and pooled proportion of major complications (4.9 vs 5.0%, P = 0.49), while uMWA had higher pooled proportions of overall and minor complications than cMWA (97.8 vs 29.7%, P < 0.01; 97.8 vs 21.0%, P < 0.01), with more patients suffering pain and skin burn after uMWA (100 vs 5.5%, P < 0.01; 47.2 vs 0.2%, P < 0.01).
CONCLUSION
MWA is an effective treatment modality for BTNs. When considering the patient's comfort, cMWA would be a more preferable procedure with less complications.
Topics: Combined Modality Therapy; Humans; Hypothermia, Induced; Microwaves; Radiofrequency Ablation; Thyroid Nodule; Treatment Outcome
PubMed: 30073455
DOI: 10.1007/s12020-018-1693-2 -
Expert Review of Anticancer Therapy Sep 2014In the last 5 years, the current management of stage I non-small-cell lung cancer has been challenged due to novel surgical approaches and advances in radiation... (Review)
Review
In the last 5 years, the current management of stage I non-small-cell lung cancer has been challenged due to novel surgical approaches and advances in radiation technology. The outcome after a sublobar resection is promising, especially for tumors less than 2 cm. Other treatment opportunities are available for high risk patients with comorbidity and impaired pulmonary function. Stereotactic ablative body radiotherapy is a good alternative treatment to surgery, especially in elderly and comorbid patients. However, randomized evidence comparing sublobar resection and stereotactic radiotherapy is presently lacking. The most recent development in radiotherapy is hadron therapy with a presumed reduced toxicity because of its peculiar physical and biological effects. Promising thermal and microwave ablative techniques are in development and have specific niche indications.
Topics: Ablation Techniques; Aged; Animals; Carcinoma, Non-Small-Cell Lung; Humans; Lung Neoplasms; Microwaves; Neoplasm Staging; Radiosurgery; Risk Factors
PubMed: 24930519
DOI: 10.1586/14737140.2014.929500 -
Anticancer Research Feb 2017Hepatocellular carcinoma (HCC) represents the fifth most common malignancy and the third cancer-related cause of death worldwide. The aim of this review was to clarify... (Review)
Review
BACKGROUND
Hepatocellular carcinoma (HCC) represents the fifth most common malignancy and the third cancer-related cause of death worldwide. The aim of this review was to clarify the role of local treatments for HCC, analyzing the indications and defining future perspectives.
MATERIALS AND METHODS
A systematic literature search was performed independently by two of the authors according to the PRISMA statement guidelines. The search was limited to studies reported in English between January 2005 and June 2016.
RESULTS
The literature search yielded 238 articles; after duplicates were removed, 179 titles and abstracts were reviewed. Most relevant data and articles about radiofrequency ablation, transarterial chemoembolization, percutaneous ethanol injection, microwave ablation and radioembolization are reported and discussed.
CONCLUSION
Data in the literature are confusing and difficult to compare due to the lack of prospective studies. Multidisciplinary and tailored approaches for each patient are key features, considering both guideline indications and patient-specific characteristics, and enhance hospital-specific best practice.
Topics: Carcinoma, Hepatocellular; Catheter Ablation; Chemoembolization, Therapeutic; Ethanol; Humans; Liver Neoplasms; Microwaves
PubMed: 28179284
DOI: 10.21873/anticanres.11331