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Human Factors Aug 2023I examine John Senders' work and discuss his influence on the study of error causation,error mitigation, and sociotechnical system safety. (Review)
Review
OBJECTIVE
I examine John Senders' work and discuss his influence on the study of error causation,error mitigation, and sociotechnical system safety.
BACKGROUND
John Senders' passing calls for an evaluation of the impact of his work.
METHOD
I review literature and accident investigation findings to discuss themes in Senders' work and potential associations between that work and error causation and system safety.
RESULTS
Senders consistently emphasized empirical rigor and theoretical exploration in his research, with the desire to apply that work to enhance human performance. He has contributed to changing the way error has been viewed, and to developing and implementing programs and techniques to mitigate error. While a causal relationship between Senders' work and safety cannot be established, an association can be drawn between his research and efforts to mitigate error.
CONCLUSION
Because of Senders' work, we have a better understanding of error causation and enhanced ways of mitigating system errors. However, new sources of error, involving advanced systems and operators' knowledge and understanding of their functionalities can, if not addressed, degrade system safety.
APPLICATION
Modifications to advanced automation and operator training are suggested, and research to improve operator expertise in interacting with automated systems proposed.
Topics: Humans; Causality; Work Performance
PubMed: 33788594
DOI: 10.1177/00187208211001982 -
Current Topics in Medicinal Chemistry 2015In last decades, diet and dietary components have been regarded as important strategies to prevent the development or mitigate numerous chronic diseases, including... (Review)
Review
In last decades, diet and dietary components have been regarded as important strategies to prevent the development or mitigate numerous chronic diseases, including inflammation, cardiovascular pathologies, cancer, etc. One of the most common dietary components of Asian population is soy. A plethora of research shows the promising effect of soy soy-based foodstuffs and genistein, which is one of the predominant isoflavone compounds, in the prevention and mitigation of stroke. Growing evidence shows that genistein, which is a selective estrogen receptor modulator, mitigates ischemic stroke-induced damages through the modification of oxidative stress and molecular pathways. The promising pharmacological role of genistein is attributed to its ability to suppress nuclear factor (NF)-kappa B and Akt signaling pathway, direct antioxidant action, and targeting estrogen and androgen-mediated molecular pathways which help to mitigate stroke damages and prolong cell survival. In this work, we systematically review the current reports on the therapeutic role of genistein against ischemic stroke and its molecular mechanism of actions.
Topics: Animals; Brain Ischemia; Genistein; Humans; Molecular Structure; Protein Kinase Inhibitors; Stroke; Structure-Activity Relationship
PubMed: 25915610
DOI: 10.2174/1568026615666150427122709 -
Frontiers in Public Health 2021The purpose of this study was to provide a scoping review on how to address and mitigate burnout in the profession of clinical oncology. Also, it examines how... (Review)
Review
The purpose of this study was to provide a scoping review on how to address and mitigate burnout in the profession of clinical oncology. Also, it examines how artificial intelligence (AI) can mitigate burnout in oncology. We searched Ovid Medline, PubMed, Scopus, and Web of Science, for articles that examine how to address burnout in oncology. A total of 17 studies were found to examine how burnout in oncology can be mitigated. These interventions were either targeted at individuals (oncologists) or organizations where the oncologists work. The organizational interventions include educational (psychosocial and mindfulness-based course), art therapies and entertainment, team-based training, group meetings, motivational package and reward, effective leadership and policy change, and staff support. The individual interventions include equipping the oncologists with adequate training that include-communication skills, well-being and stress management, burnout education, financial independence, relaxation, self-efficacy, resilience, hobby adoption, and work-life balance for the oncologists. Similarly, AI is thought to be poised to offer the potential to mitigate burnout in oncology by enhancing the productivity and performance of the oncologists, reduce the workload and provide job satisfaction, and foster teamwork between the caregivers of patients with cancer. Burnout is common among oncologists and can be elicited from different types of situations encountered in the process of caring for patients with cancer. Therefore, for these interventions to achieve the touted benefits, combinatorial strategies that combine other interventions may be viable for mitigating burnout in oncology. With the potential of AI to mitigate burnout, it is important for healthcare providers to facilitate its use in daily clinical practices. These combinatorial interventions can ensure job satisfaction, a supportive working environment, job retention for oncologists, and improved patient care. These interventions could be integrated systematically into routine cancer care for a positive impact on quality care, patient satisfaction, the overall success of the oncological ward, and the health organizations at large.
Topics: Artificial Intelligence; Burnout, Professional; Humans; Job Satisfaction; Medical Oncology; Oncologists
PubMed: 34660505
DOI: 10.3389/fpubh.2021.677915 -
Journal of the American Podiatric... 2023All clinicians are ethically obliged to prescribe responsibly and cautiously to diminish the potential for opioid diversion and to help minimize the growth of the... (Review)
Review
All clinicians are ethically obliged to prescribe responsibly and cautiously to diminish the potential for opioid diversion and to help minimize the growth of the current opioid abuse epidemic. Podiatric physicians should establish procedures to better control and limit opioid prescription and develop analgesic regimens to treat pain. The main purpose and goal of this review is to present data congruent with clinical, medical, and legal reports for allowing an appreciation of the possibility of the risk assumed when ordering and prescribing opioids within the podiatric medical profession. First, the concept and process of risk management, illustrated using a root cause analysis approach, is introduced, and application of these principles specifically to opioid prescribing is presented. Then, several examples found in both the medical and legal literature documenting the reasons for opioid prescription risk are presented. Finally, mitigating strategies for safe opioid prescribing are offered so that mitigation of opioid harm can be possible and realized by the lower-extremity specialist. Risk management strategies and tools to mitigate opioid harm, lessen opioid adverse effects, and reduce opioid deaths are presented narratively and graphically.
Topics: Humans; Analgesics, Opioid; Practice Patterns, Physicians'; Drug-Related Side Effects and Adverse Reactions; Lower Extremity; Risk Management
PubMed: 37934585
DOI: 10.7547/21-166 -
Frontiers in Pharmacology 2021We previously reported several vignettes on types and classes of drugs able to mitigate acute and, in at least one case, late radiation syndromes in mice. Most of these...
We previously reported several vignettes on types and classes of drugs able to mitigate acute and, in at least one case, late radiation syndromes in mice. Most of these had emerged from high throughput screening (HTS) of bioactive and chemical drug libraries using ionizing radiation-induced lymphocytic apoptosis as a readout. Here we report the full analysis of the HTS screen of libraries with 85,000 small molecule chemicals that identified 220 "hits." Most of these hits could be allocated by maximal common substructure analysis to one of 11 clusters each containing at least three active compounds. Further screening validated 23 compounds as being most active; 15 of these were cherry-picked based on drug availability and tested for their ability to mitigate acute hematopoietic radiation syndrome (H-ARS) in mice. Of these, five bore a 4-nitrophenylsulfonamide motif while 4 had a quinoline scaffold. All but two of the 15 significantly ( < 0.05) mitigated H-ARS in mice. We had previously reported that the lead 4-(nitrophenylsulfonyl)-4-phenylpiperazine compound (NPSP512), was active in mitigating multiple acute and late radiation syndromes in mice of more than one sex and strain. Unfortunately, the formulation of this drug had to be changed for regulatory reasons and we report here on the synthesis and testing of active analogs of NPSP512 (QS1 and 52A1) that have increased solubility in water and bioavailability while retaining mitigator activity against H-ARS ( < 0.0001) and other radiation syndromes. The lead quinoline 057 was also active in multiple murine models of radiation damage. Taken together, HTS of a total of 150,000 bioactive or chemical substances, combined with maximal common substructure analysis has resulted in the discovery of diverse groups of compounds that can mitigate H-ARS and at least some of which can mitigate multiple radiation syndromes when given starting 24 h after exposure. We discuss what is known about how these agents might work, and the importance of formulation and bioavailability.
PubMed: 34084139
DOI: 10.3389/fphar.2021.666776 -
Current Opinion in Obstetrics &... Aug 2021The purpose of this review is to increase awareness among reproductive health professionals and trainees about the impact of environmental toxicants and climate change... (Review)
Review
PURPOSE OF REVIEW
The purpose of this review is to increase awareness among reproductive health professionals and trainees about the impact of environmental toxicants and climate change on women's health and mitigation strategies at the individual, professional and governmental levels.
RECENT FINDINGS
Global health indicators reveal a meteoric rise of noncommunicable diseases over the past 50 years, which threaten reproductive health directly and indirectly. Evolutionary genetic mutations as contributors are unlikely in this timeframe, and environmental causes have been invoked. Notably, the past 75 years have witnessed marked increases in industrial chemical production, and global warming has rendered a 'climate crisis' with extreme temperatures and compromised food, water, and air quality. There is now strong experimental and epidemiologic evidence for endocrine disrupting chemicals and particulate matter and chemical components of air pollution in the pathophysiology of human reproductive disorders during development and across the lifespan, especially among vulnerable populations.
SUMMARY
Environmental impacts on fertility, pregnancy outcomes, childhood neurodevelopment, and reproductive tract development are significant, not widely appreciated, and may be preventable. In light of the evidence, education and advocating economical mitigations of toxic environmental chemicals and alternative energy strategies are imperatives to assure quality reproductive health for this and future generations.
Topics: Child; Environment; Environmental Exposure; Female; Humans; Particulate Matter; Pregnancy; Pregnancy Outcome; Reproductive Health
PubMed: 34039883
DOI: 10.1097/GCO.0000000000000722 -
Frontiers in Public Health 2022To mitigate morbidity, mortality, and impacts of heat-related illnesses (HRIs) on health, it was vital to implement a comprehensive framework for HRI prevention and... (Review)
Review
INTRODUCTION
To mitigate morbidity, mortality, and impacts of heat-related illnesses (HRIs) on health, it was vital to implement a comprehensive framework for HRI prevention and control. A recognized tool from the field of trauma prevention known as the Haddon matrix was applied. The matrix states that any event is affected by three factors: host, agent, and environment. In addition, another recognized tool known as the combined model was used in this study. The combined model is a three-dimensional model that includes the idea for the three axes of Haddon's matrix with the methodology of the community risk reduction (CRR) model.
AIM OF THE STUDY
To identify the environmental and individual risk factors of HRIs based on the Haddon matrix and the recommended prevention strategies by the CRR tool by using the combined model.
METHODOLOGY
An extensive literature review was conducted to assess all the risk factors associated with HRI, as well as preventive measures. Then the Haddon matrix was used to structure, separating human factors from technical and environmental details and timing. After that, the combined model was used to set all responses and mitigation measures for each element obtained from the Haddon matrix tool.
CONCLUSION
Projected increases in heat stress over the globe require the formulation and implementation of evidence-based HRI mitigation and preventive measures. In this study, we implemented the combined model that was utilized as a systematic strategy for the more theoretical framework of Haddon's matrix. Using the Haddon matrix to determine the HRI risk factors and the combined model to mitigate its impact was practical and helpful in planning, preparedness, and mitigating the HRIs during Hajj, provided a broad approach equivalent to the Swiss cheese model, and would facilitate an informed decision.
Topics: Humans; Mass Gatherings; Morbidity; Risk Factors
PubMed: 36062122
DOI: 10.3389/fpubh.2022.957576 -
Journal of Pharmaceutical Sciences Apr 2022Immunogenicity to biologics is often observed following dosing in human subjects during clinical trials. Both product and host specific factors may be implicated in... (Review)
Review
Immunogenicity to biologics is often observed following dosing in human subjects during clinical trials. Both product and host specific factors may be implicated in contributing to a potential immune response. However, even if such risk factors are identified and eliminated as part of the rational quality by design approaches, the outcome in clinic can be uncertain and challenging to predict. Several tools have been employed to identify these risk factors and consequent mitigation approaches implemented prior to dosing in humans. However, the complexity of the immune system with an interplay of network of immune cells involved in driving a long- term immune response as well as patient characteristics, can make it challenging to predict the outcome in clinic. This perspective will provide an insight into recent advances in the risk assessment approaches that are utilized during preclinical stage of development of a biologic. The outputs from such tools can help to rank order and select the most optimal candidate with the least likelihood of an immune response and can further drive the development of a clinical bioanalytical and immunogenicity monitoring strategy. Such a strategy can be proactively shared with the regulators along with the proposal to streamline clinical immunogenicity and personalizing the outcome based on pharmacogenomics and other patient-related factors. This paper provides a roadmap on performing risk assessments through a systematic identification of risks and their mitigations wherever possible. Recommendations on incorporating the key components of such risk assessments as part of the new regulatory submissions are also provided. Shorter abstract Immunogenicity to biologics is common during clinical trials. Both product and host specific factors have been implicated. Several risk assessment tools can be used to identify and mitigate the risk factors responsible for immunogenicity. An insight into recent advances in the risk assessment approaches will be presented. The outputs can define a risk score and guide the clinical bioanalytical and immunogenicity monitoring strategy. A roadmap on performing risk assessments through a systematic identification of risks and their mitigations wherever possible is provided. Best practices for a risk assessment strategy and recommendations on the content for IND and the Integrated summary of Immunogenicity are also provided.
Topics: Biological Products; Humans; Risk Assessment; Risk Factors
PubMed: 35122828
DOI: 10.1016/j.xphs.2022.01.032 -
The Science of the Total Environment Apr 2023The impact of aviation on climate change is reflected in increasing emissions of CO2 and other pollutants from fuel burning emitted at high altitudes, representing 2.9 %...
The impact of aviation on climate change is reflected in increasing emissions of CO2 and other pollutants from fuel burning emitted at high altitudes, representing 2.9 % of total Greenhouse gases (GHG) emissions in 2019. However, mitigations options for decarbonization of aviation are difficult to implement given operational safety, technology maturity, energy density and other constraints. One alternative for mitigation is the use of certified sustainable aviation fuel (SAF) with lower carbon intensity than conventional jet fuel (CJF). This research presents an inventory of Argentine civil aviation emissions for its domestic and international flights, and analyzes the possibility of supplying SAF as a mitigation strategy given its abundant biomass production. Argentine aviation activity is presented as a monthly 4D (latitude, longitude, altitude and time) spatial inventory for the interval 2001-2021, based on origin and destination city pairs, aircraft types and airlines. Fuel consumption and pollutant emissions were calculated for landing-and-take-off and cruise phases. Monthly domestic ranged from 67 to 179 kt CO (2001-2019). Annual peak values occurred in 2019 consuming 560 kt CJF and direct emitting of 1.77 Mt CO. While Revenue-Passenger-Kilometer (RPK) grew almost 4 times (4.18 × 10 in 2001 to 16.42 × 10 in 2019), the number of flights changed only 1.5 times (from 98,000 in 2002 to 152,000 in 2019). The main efficiency indexes varied from 97 t CJF/RPK, 308 gCO/RPK to 34 t CJF/RPK, 107 gCO/RPK between 2001 and 2019, respectively, showing an average annual improvement of 3.5 % due to partial fleet renewal, especially from 2015 onwards. Emissions of other pollutants for 2019 reached total values of CO 14.14 kt; NOx 6.77 kt; PM tot 55.12 kt. For the period 2001-2019, international aviation consumed between 1 Mt - 1.5 Mt CJF, directly emitting between 3.30 and 4.80 Mt of CO; RPKs went from 6.234 × 10 to 20.524 × 10; the efficiency indices ranged from 529 to 240 gCO/RPK. The most important changes occurred with an optimization of routes and number of flights and the replacement of the four-engines (B747, A380) by more efficient twin-engines (B777, A330) aircraft. Argentina is not required to any offsetting regulatory program due to its small aviation market (approx. 0.22 % global market in 2019), nor has to date certified SAF production pathways, nevertheless it has potential for SAF availability based on actual biofuels production (ethanol, biodiesel and soybean oil) and biomass feedstock's existences. In this sense this studies proposes that 2019 domestic fuel consumption could be supplied using 79 % exportable amounts of sugarcane ethanol (257 ± 53 kt) (by Ethanol to Jet ETJ) and 34 % of exportable soybean oil (1079 ± 160 kt) (by hydroprocessed esters and fatty acids- HEFA) pathways. For this scenario average GHG emissions reached 1.321 ± 0.115 Mt CO2eq; which would imply a 62 % of the current emission value using CJF (2.17Mt CO2eq), or savings of about 838 kt CO2eq (38 %). At the 2019 level of harvest and biofuel production, up to 1.4 Mt of SAF could be produced from sugarcane ethanol/ETJ and soybean oil/HEFA mitigating up to 1.8 MtCO2eq. A 35 kt CO annual sectoral national mitigation strategy could be reached by using 14 kt of SAF.
PubMed: 36669658
DOI: 10.1016/j.scitotenv.2023.161675 -
Frontiers in Pharmacology 2021There is a need for countermeasures to mitigate lethal acute radiation syndrome (ARS) and delayed effects of acute radiation exposure (DEARE). In WAG/RijCmcr rats, ARS...
There is a need for countermeasures to mitigate lethal acute radiation syndrome (ARS) and delayed effects of acute radiation exposure (DEARE). In WAG/RijCmcr rats, ARS occurs by 30-days following total body irradiation (TBI), and manifests as potentially lethal gastrointestinal (GI) and hematopoietic (H-ARS) toxicities after >12.5 and >7 Gy, respectively. DEARE, which includes potentially lethal lung and kidney injuries, is observed after partial body irradiation >12.5 Gy, with one hind limb shielded (leg-out PBI). The goal of this study is to enhance survival from ARS and DEARE by polypharmacy, since no monotherapy has demonstrated efficacy to mitigate both sets of injuries. For mitigation of ARS following 7.5 Gy TBI, a combination of three hematopoietic growth factors (polyethylene glycol (PEG) human granulocyte colony-stimulating factor (hG-CSF), PEG murine granulocyte-macrophage-CSF (mGM-CSF), and PEG human Interleukin (hIL)-11), which have shown survival efficacy in murine models of H-ARS were tested. This triple combination (TC) enhanced survival by 30-days from ∼25% to >60%. The TC was then combined with proven medical countermeasures for GI-ARS and DEARE, namely enrofloxacin, saline and the angiotensin converting enzyme inhibitor, lisinopril. This combination of ARS and DEARE mitigators improved survival from GI-ARS, H-ARS, and DEARE after 7.5 Gy TBI or 13 Gy PBI. Circulating blood cell recovery as well as lung and kidney function were also improved by TC + lisinopril. Taken together these results demonstrate an efficacious polypharmacy to mitigate radiation-induced ARS and DEARE in rats.
PubMed: 34079456
DOI: 10.3389/fphar.2021.634477