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Frontiers in Cellular and Infection... 2023
Topics: Pathology, Molecular; Fungi; Basidiomycota; Oomycetes
PubMed: 37886668
DOI: 10.3389/fcimb.2023.1305306 -
Expert Reviews in Molecular Medicine May 2016
Topics: Editorial Policies; Humans; Molecular Medicine; Peer Review, Research
PubMed: 27160347
DOI: 10.1017/erm.2016.10 -
Journal Der Deutschen Dermatologischen... Mar 2022
Topics: Dermatology; Humans; Pathology, Molecular
PubMed: 35304963
DOI: 10.1111/ddg.14760 -
Advanced Drug Delivery Reviews Oct 2023Ocular surface neovascularization and its resulting pathological changes significantly alter corneal refraction and obstruct the light path to the retina, and hence is a... (Review)
Review
Ocular surface neovascularization and its resulting pathological changes significantly alter corneal refraction and obstruct the light path to the retina, and hence is a major cause of vision loss. Various factors such as infection, irritation, trauma, dry eye, and ocular surface surgery trigger neovascularization via angiogenesis and lymphangiogenesis dependent on VEGF-related and alternative mechanisms. Recent advances in antiangiogenic drugs, nanotechnology, gene therapy, surgical equipment and techniques, animal models, and drug delivery strategies have provided a range of novel therapeutic options for the treatment of ocular surface neovascularization. In this review article, we comprehensively discuss the etiology and mechanisms of corneal neovascularization and other types of ocular surface neovascularization, as well as emerging animal models and drug delivery strategies that facilitate its management.
Topics: Animals; Molecular Medicine; Neovascularization, Pathologic; Corneal Neovascularization; Retina; Angiogenesis Inhibitors
PubMed: 37689278
DOI: 10.1016/j.addr.2023.115084 -
Trends in Molecular Medicine May 2021
Topics: Autobiographies as Topic; Humans; Molecular Medicine
PubMed: 33840623
DOI: 10.1016/j.molmed.2021.03.002 -
Trends in Molecular Medicine Mar 2021
Topics: Humans; Molecular Medicine
PubMed: 33568327
DOI: 10.1016/j.molmed.2021.01.002 -
Current Allergy and Asthma Reports Jun 2018The aim of this article is to discuss how allergen-specific immunotherapy (AIT) can be improved through molecular approaches. We provide a summary of next-generation... (Review)
Review
PURPOSE OF REVIEW
The aim of this article is to discuss how allergen-specific immunotherapy (AIT) can be improved through molecular approaches. We provide a summary of next-generation molecular AIT approaches and of their clinical evaluation. Furthermore, we discuss the potential of next generation molecular AIT forms for the treatment of severe manifestations of allergy and mention possible future molecular strategies for the secondary and primary prevention of allergy.
RECENT FINDINGS
AIT has important advantages over symptomatic forms of allergy treatment but its further development is limited by the quality of the therapeutic antigen preparations which are derived from natural allergen sources. The field of allergy diagnosis is currently undergoing a dramatic improvement through the use of molecular testing with defined, mainly recombinant allergens which allows high-resolution diagnosis. Several studies demonstrate that molecular testing in early childhood can predict the development of symptomatic allergy later on in life. Clinical studies indicate that molecular AIT approaches have the potential to improve therapy of allergic diseases and may be used as allergen-specific forms of secondary and eventually primary prevention for allergy.
Topics: Allergens; Child; Desensitization, Immunologic; Humans; Hypersensitivity; Molecular Medicine; Primary Prevention
PubMed: 29886521
DOI: 10.1007/s11882-018-0790-x -
Ticks and Tick-borne Diseases Mar 2022Molecular biology has revolutionized all aspects of biological research including diagnostics, taxonomy, and systematics. Even so, the critique that molecular methods... (Review)
Review
Molecular biology has revolutionized all aspects of biological research including diagnostics, taxonomy, and systematics. Even so, the critique that molecular methods cannot truly confirm the presence of parasites, or identify new species remains prevalent and arguably relevant. The current review considers the ability of molecular diagnostic methods to detect parasites and the relevance of molecular sequences to identify species and attempt to answer the question of whether molecular data ever lie. It shows that well-validated molecular assays should be able to accurately confirm the presence of parasites in a host or vector species, while well-selected sequences should conclusively identify existing or new species. It addresses pitfalls in the use of molecular techniques and how these can be avoided. It also considers the self-correcting nature of science and the caveat that a scientist should use all tools at their disposal to uncover the mysteries of nature.
Topics: Animals; Parasites; Pathology, Molecular
PubMed: 35078135
DOI: 10.1016/j.ttbdis.2022.101907 -
Cytopathology : Official Journal of the... Feb 2018Training in molecular cytopathology testing is essential in developing and maintaining skills in modern molecular technologies as they are introduced to a universal... (Review)
Review
Training in molecular cytopathology testing is essential in developing and maintaining skills in modern molecular technologies as they are introduced to a universal health care system such as extant in the UK and elsewhere. We review the system in place in Northern Ireland (NI) for molecular testing of solid tumours, as an example to train staff of all grades, including pathologists, clinical scientists, biomedical scientists and equivalent technical grades. We describe training of pathologists as part of the NI Deanery medical curriculum, the NI training programme for scientists and laboratory rotation for Biomedical Scientists. Collectively, the aims of our training are two-fold: to provide a means by which individuals may extend their experience and skills; and to provide and maintain a skilled workforce for service delivery. Through training and competency, we introduce new technologies and tests in response to personalised medicine therapies with a competent workforce. We advocate modifying programmes to suit individual needs for skill development, with formalised courses in pre-analytical, analytical and postanalytical demands of modern molecular pathology. This is of particular relevance for cytopathology in small samples such those from formalin-fixed paraffin-embedded cell blocks. We finally introduce how university courses can augment training and develop a skilled workforce to benefit the delivery of services to our patients.
Topics: Curriculum; Cytodiagnosis; Health Personnel; Humans; Ireland; Pathology, Molecular; Precision Medicine
PubMed: 29148178
DOI: 10.1111/cyt.12495 -
American Journal of Clinical Pathology Jul 2020At a discussion on molecular/cytogenetic education for hematopathology fellows at the 2018 Society for Hematopathology Program Directors Meeting, consensus was that...
OBJECTIVES
At a discussion on molecular/cytogenetic education for hematopathology fellows at the 2018 Society for Hematopathology Program Directors Meeting, consensus was that fellows should understand basic principles and indications for and limitations of molecular/cytogenetic testing used in routine practice. Fellows should also be adept at integrating results of such testing for rendering a final diagnosis. To aid these consensus goals, representatives from the Society for Hematopathology and the Association for Molecular Pathology formed a working group to devise a molecular/cytogenetic curriculum for hematopathology fellow education.
CURRICULUM SUMMARY
The curriculum includes a primer on cytogenetics and molecular techniques. The bulk of the curriculum reviews the molecular pathology of individual malignant hematologic disorders, with applicable molecular/cytogenetic testing for each and following the 2017 World Health Organization classification of hematologic neoplasms. Benign hematologic disorders and bone marrow failure syndromes are also discussed briefly. Extensive tables are used to summarize genetics of individual disorders and appropriate methodologies.
CONCLUSIONS
This curriculum provides an overview of the current understanding of the molecular biology of hematologic disorders and appropriate ancillary testing for their evaluation. The curriculum may be used by program directors for training hematopathology fellows or by practicing hematopathologists.
Topics: Curriculum; Education, Medical, Graduate; Fellowships and Scholarships; Hematology; Humans; Pathology, Clinical; Pathology, Molecular
PubMed: 32444878
DOI: 10.1093/ajcp/aqaa038