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Seminars in Neurology Feb 2020Environmental circumstances that result in ambiguity or conflict with the patterns of sensory stimulation may adversely affect the vestibular system. The effect of this... (Review)
Review
Environmental circumstances that result in ambiguity or conflict with the patterns of sensory stimulation may adversely affect the vestibular system. The effect of this conflict in sensory information may be dizziness, a sense of imbalance, nausea, and motion sickness sometimes even to seemingly minor daily head movement activities. In some, it is not only exposure to motion but also the observation of objects in motion around them such as in supermarket aisles or other places with visual commotion; this can lead to dizziness, nausea, or a feeling of motion sickness that is referred to as . All people with normal vestibular function can be made to experience motion sickness, although individual susceptibility varies widely and is at least partially heritable. Motorists learn to interpret sensory stimuli in the context of the car stabilized by its suspension and guided by steering. A type of motorist's disorientation occurs in some individuals who develop a heightened awareness of perceptions of motion in the automobile that makes them feel as though they may be rolling over on corners and as though they are veering on open highways or in streaming traffic. This article discusses the putative mechanisms, consequences and approach to managing patients with visual vertigo, motion sickness, and motorist's disorientation syndrome in the context of chronic dizziness and motion sensitivity.
Topics: Automobile Driving; Confusion; Dizziness; Humans; Motion Sickness; Vertigo
PubMed: 32045940
DOI: 10.1055/s-0040-1701653 -
Acta Oto-laryngologica May 2017Elevated Motion Sickness Susceptibility (MSS) in Meniere?s disease (MD) is likely to be a consequence of the onset of MD and not migraine per se.
CONCLUSION
Elevated Motion Sickness Susceptibility (MSS) in Meniere?s disease (MD) is likely to be a consequence of the onset of MD and not migraine per se.
OBJECTIVES
Pathologies of the vestibular system influence MSS. Bilateral vestibular deficits lower MSS, vestibular neuritis or benign paroxysmal positional vertigo have little overall effect, whereas vestibular migraine elevates MSS. However, less is known about MSS in MD, a condition in which many patients experience vestibular loss and migraine symptoms.
METHODS
The authors conducted an online survey that posed diagnostic and disease questions before addressing frequency of headaches, migraines, visual display dizziness (VDD), syncope, social life, and work impact of dizziness (SWID4) and motion sickness susceptibility (MSSQ). The two groups were: diagnosed MD individuals with hearing loss (n = 751) and non-MD individuals in the control group (n = 400).
RESULTS
The MD group showed significantly elevated MSS, more headache and migraine, increased VDD, higher SWID4 scores, and increased syncope. MSS was higher in MD than controls only after the development of MD, but not before, nor in childhood. Although elevated in MD compared with controls, MSS was lower than migraine patients from past data. Multivariate analysis revealed VDD, SWID4, and MSS in adulthood as the strongest predictors of MD, but not headache nor migraine.
Topics: Adult; Case-Control Studies; Female; Humans; Male; Meniere Disease; Middle Aged; Migraine Disorders; Motion Sickness; Surveys and Questionnaires; United Kingdom
PubMed: 27918236
DOI: 10.1080/00016489.2016.1255775 -
International Journal of Pediatric... Jul 2022Easily available clinical tests to evaluate postural control are needed. Furthermore, motion sickness (MS) and postural control are correlated. The aims of this study...
OBJECTIVE
Easily available clinical tests to evaluate postural control are needed. Furthermore, motion sickness (MS) and postural control are correlated. The aims of this study were to compare the internal validity of a set of clinical tests of postural control with the internal validity of static posturography and to evaluate possible associations between postural control and MS.
METHODS
We included healthy subjects from a primary school in Denmark who completed questionnaires about MS and underwent two rounds of clinical tests of postural control and static posturography using a Tetrax Interactive Balance System two weeks apart. For clinical tests of postural control, subjects were observed for up to 30 s standing on both legs, on one leg, on a pillow both with their eyes open and again with their eyes closed.
RESULTS
Twenty-one subjects were included: 71% males with an average age of 13.7 years. Agreement rates ranged from 62% to 95% between test and retest in clinical tests.; lowest for subjects standing on their non dominant leg with their eyes open and highest for subjects performing Romberg's test with their eyes closed along with subjects standing on a pillow with their eyes open. For several of these tests, almost all subjects were able to hold their balance for the full 30 s. Test-retesting using static posturography by Bland Altman plot showed datapoints scattered equally above and below the mean line indicating no systematic bias. Results of clinical tests and static posturography were not associated. MS was reported from 43% of subjects and a trend was observed with high sway scores from subjects suffering from MS. This was statistically insignificant.
CONCLUSIONS
Due to a ceiling effect, subjects achieved the same scores in both rounds of testing in several of the clinical tests, reducing the clinical importance of these tests. Compared to clinical tests, static posturography seemingly remains the superior method when it comes to evaluation of postural control, although not as easily applicable in a daily clinical setting. When comparing MS and postural control a trend was observed, indicating higher sway scores in subjects suffering from MS.
Topics: Adolescent; Denmark; Female; Humans; Male; Motion Sickness; Postural Balance
PubMed: 35580384
DOI: 10.1016/j.ijporl.2022.111139 -
European Journal of Paediatric... Sep 2020Susceptibility to severe motion sickness has not been well described in the pediatric population, particularly in very young children. This study aimed to describe and...
INTRODUCTION
Susceptibility to severe motion sickness has not been well described in the pediatric population, particularly in very young children. This study aimed to describe and evaluate risk factors and treatment responses in a group of children with severe motion sickness, including infants and toddlers.
METHODS
We conducted a retrospective review of patients less than 18 years of age seen in our pediatric vestibular program for evaluation of motion sickness over a 6-year period.
RESULTS
A total of 23 patients with motion sickness were identified. Age of onset ranged from 0 to 15 years old, with a mean age of 6.6 ± 4.2 years. Eleven patients (47.8%) were diagnosed with a migraine variant. Vestibular deficits were identified in four out of 17 patients (23.5%) who underwent formal vestibular testing. Other frequent comorbid conditions included recurrent/chronic otitis media (n = 9; 39.1%) and a history of motor delay (n = 7; 30.4%). A high proportion of patients reported symptom improvement when treated with meclizine, ondansetron, cyproheptadine, or vestibular rehabilitation.
DISCUSSION
Motion sickness can impact children even in infancy. Common comorbid conditions that may contribute to pediatric motion sickness include migraine disorders, vestibular impairment, otitis media, and motor delay. Treatments such as cyproheptadine and vestibular rehabilitation may be helpful but require further study.
Topics: Adolescent; Child; Child, Preschool; Comorbidity; Female; Humans; Infant; Infant, Newborn; Male; Migraine Disorders; Motion Sickness; Otitis Media; Retrospective Studies; Risk Factors; Vestibular Diseases
PubMed: 32682672
DOI: 10.1016/j.ejpn.2020.06.010 -
Proceedings of the National Academy of... Oct 2023Travel can induce motion sickness (MS) in susceptible individuals. MS is an evolutionary conserved mechanism caused by mismatches between motion-related sensory...
Travel can induce motion sickness (MS) in susceptible individuals. MS is an evolutionary conserved mechanism caused by mismatches between motion-related sensory information and past visual and motion memory, triggering a malaise accompanied by hypolocomotion, hypothermia, hypophagia, and nausea. Vestibular nuclei (VN) are critical for the processing of movement input from the inner ear. Motion-induced activation of VN neurons recapitulates MS-related signs. However, the genetic identity of VN neurons mediating MS-related autonomic and aversive responses remains unknown. Here, we identify a central role of cholecystokinin (CCK)-expressing VN neurons in motion-induced malaise. Moreover, we show that CCK VN inputs onto the parabrachial nucleus activate -expressing neurons and are sufficient to establish avoidance to novel food, which is prevented by CCK-A receptor antagonism. These observations provide greater insight into the neurobiological regulation of MS by identifying the neural substrates of MS and providing potential targets for treatment.
Topics: Animals; Mice; Motion Sickness; Movement; Neurons; Vestibular Nuclei; Vestibule, Labyrinth
PubMed: 37847729
DOI: 10.1073/pnas.2304933120 -
Journal of Vestibular Research :... 2022Chronic motion sensitivity (CMS) is a combination of autonomic symptoms provoked by exposure to motion. The correlation between anxiety and CMS is not yet well...
BACKGROUND
Chronic motion sensitivity (CMS) is a combination of autonomic symptoms provoked by exposure to motion. The correlation between anxiety and CMS is not yet well understood.
OBJECTIVES
1) To compare median anxiety levels between young adults with and without CMS. 2) To examine the effect of anxiety on postural stability with immersion virtual reality. 3) To compare anxiety levels between sexes.
METHODS
Participants included 60 adults (20-40 years), with and without CMS. After determining their current and general anxiety levels, postural stability was measured.
RESULTS
There were significant differences in median (minimum, maximum) state- and trait-anxiety scores between participants with and without CMS, but no significant differences in median state- and trait-anxiety scores between males and females with CMS. There was a significant inverse relationship between state- and trait-anxiety scores and postural stability (ρ= -0.28, p = 0.03, and ρ= -0.32, p = 0.01, respectively). The stepwise regression analysis showed the Motion Sickness Susceptibility Questionnaire-Short Form score to be the only variable contributing significantly to postural stability (R2 = 26.2%; t = -4.5, p < 0.001).
CONCLUSIONS
Young adults with CMS are more anxious, although anxiety does not contribute to postural stability in this group. Anxiety levels do not appear to differ between young adult males and females with CMS.
Topics: Anxiety; Anxiety Disorders; Female; Humans; Male; Motion Sickness; Postural Balance; Virtual Reality; Young Adult
PubMed: 34486999
DOI: 10.3233/VES-201625 -
Experimental Brain Research Dec 2022Driving simulators are an increasingly important tool to develop vehicle functionalities and to study driver or passenger responses. A major hindrance to the use and... (Meta-Analysis)
Meta-Analysis Review
Driving simulators are an increasingly important tool to develop vehicle functionalities and to study driver or passenger responses. A major hindrance to the use and validity of such studies is Simulator Sickness (SS). Several studies have suggested a positive relation between improvements in simulator fidelity and the likelihood of sickness. We hypothesized that this relation only holds true for static (fixed-base) simulators, and that increased fidelity in fact reduces simulator sickness in dynamic (moving-base) simulators. We performed a meta-analysis investigating the relation between sickness and fidelity in static and dynamic systems. A literature search yielded a total of 41 simulator studies that varied aspects of mechanical and/or visual fidelity and assessed SS for the same driving conditions and the same or equivalent participant groups. Evaluation of a model synthesizing the findings of these studies indicates that SS decreases with visual fidelity, and suggests that this effect may be negated for static simulators. The results of the modeling efforts thereby provide some support for the hypothesis that increased fidelity can reduce SS in dynamic simulators. Based on the evaluation of the literature we also note particular shortcomings and gaps in available research. Finally, we make recommendations for specific experiments that may fill these gaps and allow definitive conclusions on the role of simulator fidelity in SS.
Topics: Humans; Motion Sickness; Computer Simulation; Automobile Driving
PubMed: 36260094
DOI: 10.1007/s00221-022-06485-6 -
Deutsches Arzteblatt International Mar 2019
Topics: Humans; Motion Sickness; Neurophysiology
PubMed: 30995957
DOI: 10.3238/arztebl.2019.0175b -
Scientific Reports Jan 2022Competitive Offshore Ocean Sailing is a highly demanding activity in which subjects are exposed to psychophysical stressors for a long time. To better define the... (Observational Study)
Observational Study
Competitive Offshore Ocean Sailing is a highly demanding activity in which subjects are exposed to psychophysical stressors for a long time. To better define the physiological adaptations, we investigated the stress response of subjects exposed to 3-days long ocean navigation with disruption of circadian rhythms. 6 male subjects were involved in the study and provided urine and saliva samples before setting sail, during a single day of inshore sailing, during 3-days long ocean navigation, and at the arrival, to measure oxidative stress, cortisol, nitric oxide metabolites (NOx) and metabolic response. Motion Sickness questionnaires were also administered during the navigation. The crew suffered a mean weight loss of 1.58 kg. After the long navigation, a significant increase in ROS production and decrease in total antioxidant capacity and uric acid levels were observed. Lipid peroxidation, NO metabolites, ketones, creatinine, and neopterin levels were also increased. Furthermore, a significant increase in cortisol levels was measured. Finally, we found a correlation between motion sickness questionnaires with the increase of NOx, and no correlation with cortisol levels. Physical and psychological stress response derived from offshore sailing resulted in increased oxidative stress, nitric oxide metabolites, and cortisol levels, unbalanced redox status, transient renal function impairment, and ketosis. A direct correlation between motion sickness symptoms evaluated through questionnaires and NOx levels was also found.
Topics: Adult; Circadian Rhythm; Humans; Lipid Peroxidation; Male; Middle Aged; Motion Sickness; Nitric Oxide; Oxidative Stress; Surveys and Questionnaires; Water Sports
PubMed: 35064225
DOI: 10.1038/s41598-022-05219-6 -
Frontiers in Neural Circuits 2023Space Motion Sickness (SMS) is a syndrome that affects around 70% of astronauts and includes symptoms of nausea, dizziness, fatigue, vertigo, headaches, vomiting, and...
INTRODUCTION
Space Motion Sickness (SMS) is a syndrome that affects around 70% of astronauts and includes symptoms of nausea, dizziness, fatigue, vertigo, headaches, vomiting, and cold sweating. Consequences range from discomfort to severe sensorimotor and cognitive incapacitation, which might cause potential problems for mission-critical tasks and astronauts and cosmonauts' well-being. Both pharmacological and non-pharmacological countermeasures have been proposed to mitigate SMS. However, their effectiveness has not been systematically evaluated. Here we present the first systematic review of published peer-reviewed research on the effectiveness of pharmacological and non-pharmacological countermeasures to SMS.
METHODS
We performed a double-blind title and abstract screening using the online Rayyan collaboration tool for systematic reviews, followed by a full-text screening. Eventually, only 23 peer-reviewed studies underwent data extraction.
RESULTS
Both pharmacological and non-pharmacological countermeasures can help mitigate SMS symptoms.
DISCUSSION
No definitive recommendation can be given regarding the superiority of any particular countermeasure approach. Importantly, there is considerable heterogeneity in the published research methods, lack of a standardized assessment approach, and small sample sizes. To allow for consistent comparisons between SMS countermeasures in the future, standardized testing protocols for spaceflight and ground-based analogs are needed. We believe that the data should be made openly available, given the uniqueness of the environment in which it is collected.
SYSTEMATIC REVIEW REGISTRATION
https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021244131.
Topics: Humans; Randomized Controlled Trials as Topic; Space Flight; Space Motion Sickness; Vestibule, Labyrinth; Weightlessness
PubMed: 37396400
DOI: 10.3389/fncir.2023.1150233