-
IDCases 2020is a slow growing acid-fast bacillus (AFB) in the nontuberculous mycobacteria (NTM) group. typically causes cervicofacial lymphadenitis in children, cutaneous...
is a slow growing acid-fast bacillus (AFB) in the nontuberculous mycobacteria (NTM) group. typically causes cervicofacial lymphadenitis in children, cutaneous diseases, septic arthritis and osteomyelitis. However, it rarely causes isolated spinal cord disease. We report the first case, to our knowledge, of isolated intramedullary spinal lesions secondary to . This case involved a patient with newly diagnosed human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS). He developed significant immune reconstitution inflammatory syndrome (IRIS) during his treatment. should be on the differential for isolated intramedullary spinal lesions, particularly in immunocompromised patients. Given our patient's severe IRIS, patients with HIV and infection should be closely monitored for IRIS and treated aggressively. In high risk circumstances such as spinal disease in patients with HIV, clinicians should consider pre-emptive treatment for IRIS.
PubMed: 32226763
DOI: 10.1016/j.idcr.2019.e00674 -
International Journal of Dermatology Sep 2021
Topics: Humans; Mycobacterium Infections; Mycobacterium haemophilum; Polymerase Chain Reaction; RNA, Ribosomal, 16S
PubMed: 33751550
DOI: 10.1111/ijd.15514 -
Journal of Clinical Rheumatology :... Jan 2021
Topics: Humans; Liver Transplantation; Mycobacterium haemophilum; Tenosynovitis
PubMed: 31880608
DOI: 10.1097/RHU.0000000000001232 -
Frontiers in Medicine 2023is a slow-growing, aerobic mycobacterium that acts as a pathogen in immunocompromised adult patients and immunocompetent children. There are only a few rare cases in...
is a slow-growing, aerobic mycobacterium that acts as a pathogen in immunocompromised adult patients and immunocompetent children. There are only a few rare cases in the literature describing this species as a cause of subcutaneous infections. Here, we describe a subcutaneous infection caused by in an immunocompetent female after lipolysis injections at an unqualified beauty salon, suggesting that this bacteria can also be a potential causative agent of adverse events in medical aesthetics. In addition, caused lesions not only at the injection sites and adjacent areas but also invaded distant sections through the subcutaneous sinus tracts. Thus, early diagnosis and appropriate treatment are vital to prevent further deterioration and improve prognosis.
PubMed: 36756175
DOI: 10.3389/fmed.2023.1098047 -
Journal of Clinical Microbiology Feb 2019
Topics: Diagnosis, Differential; Humans; Molecular Diagnostic Techniques; Multiplex Polymerase Chain Reaction; Mycobacterium Infections; Mycobacterium haemophilum; Mycobacterium leprae; Sensitivity and Specificity
PubMed: 30463891
DOI: 10.1128/JCM.01760-18 -
Annals of Neurology Mar 2024
Topics: Humans; Mycobacterium haemophilum; Myelitis
PubMed: 37953637
DOI: 10.1002/ana.26828 -
Journal of Korean Medical Science Dec 2019Nontuberculous mycobacteria (NTM) lymphadenitis is an under-recognized entity, and data of the true burden in children are limited. Without a high index of suspicion,...
BACKGROUND
Nontuberculous mycobacteria (NTM) lymphadenitis is an under-recognized entity, and data of the true burden in children are limited. Without a high index of suspicion, diagnosis may be delayed and microbiological detection is challenging. Here, we report a cluster of NTM lymphadenitis experienced in Korean children.
METHODS
Subjects under 19 years of age diagnosed with NTM lymphadenitis during November 2016-April 2017 and April 2018 were included. Electronic medical records were reviewed for clinical, laboratory and pathological findings. Information regarding underlying health conditions and environmental exposure factors was obtained through interview and questionnaires.
RESULTS
A total of ten subjects were diagnosed during 18 months. All subjects were 8-15 years of age, previously healthy, male and had unilateral, nontender, cervicofacial lymphadenitis for more than 3 weeks with no significant systemic symptoms and no response to empirical antibiotics. Lymph nodes involved were submandibular (n = 8), preauricular (n = 6) and submental (n = 1). Five patients had two infected nodes and violaceous discoloration was seen in seven subjects. Biopsy specimens revealed chronic granulomatous inflammation and acid-fast bacteria culture identified in two cases and NTM polymerase chain reaction was positive in two cases. Survey revealed various common exposure sources.
CONCLUSION
NTM lymphadenitis is rare but increasing in detection and it may occur in children and adolescents. Diagnosis requires high index of suspicion and communication between clinicians and the laboratory is essential for identification of NTM.
Topics: Adolescent; Anti-Bacterial Agents; Child; Humans; Lymphadenitis; Male; Mycobacterium Infections, Nontuberculous; Mycobacterium haemophilum; Nontuberculous Mycobacteria; RNA, Bacterial
PubMed: 31779059
DOI: 10.3346/jkms.2019.34.e302 -
Zebrafish Feb 2019In 2017, the zebrafish unit at University of Glasgow experienced a detrimental outbreak of pathogenic bacterium, Mycobacterium haemophilum. The presence of other...
In 2017, the zebrafish unit at University of Glasgow experienced a detrimental outbreak of pathogenic bacterium, Mycobacterium haemophilum. The presence of other bacterial species was also confirmed by bacteriology growth in the same unit. The affected individuals composed of a wild-origin parental population sourced from India and their F1 offspring generation. Bacteria were diagnostically confirmed to be present systemically in fish and within the water and biofilm of the recirculating zebrafish system. In the absence of a publicly accessible step-by-step disinfectant protocol for these difficult-to-eliminate pathogens, we devised a successful procedure to eradicate mycobacteria and Aeromonas species after colony removal using Cleanline Chlorine tablets (active ingredient Sodium dichloroisocyanurate) and Virkon Aquatic. Postdisinfection diagnostics did not detect pathogens in the system or in the new fish inhabiting the system that were tested. Newly established fish colonies have not shown similar clinical signs or disease-induced mortality in the 1-year period following system disinfection and repopulation. We present a historical background of the bacterial outbreak and a disinfection method which can be replicated in other zebrafish facilities-at small or large scales-for reliable mycobacterium removal. This procedure can be implemented as a disinfection protocol before the introduction of a new fish population to a previously contaminated system.
Topics: Animals; Disease Eradication; Disease Outbreaks; Disinfectants; Disinfection; Fish Diseases; Mycobacterium Infections; Mycobacterium haemophilum; Zebrafish
PubMed: 30358522
DOI: 10.1089/zeb.2018.1628 -
International Journal of Dermatology Aug 2021
Topics: Aged; Dermatitis; Forearm; Humans; Mycobacterium Infections; Mycobacterium haemophilum; Skin Diseases, Bacterial
PubMed: 33650117
DOI: 10.1111/ijd.15484 -
Pediatric Dermatology 2016Nontuberculous mycobacteria rarely cause facial skin lesions in immunocompetent children.
BACKGROUND
Nontuberculous mycobacteria rarely cause facial skin lesions in immunocompetent children.
AIM
I describe the clinical features and treatment of nontuberculous mycobacteria facial lesions.
MATERIALS AND METHODS
The diagnosis of a facial nontuberculous mycobacteria infection was established using polymerase chain reaction.
RESULTS
Of 286 children with confirmed nontuberculous mycobacteria infection, 14 (4.9%; median age 50 mos, range 9-156 mos; 5 [36%] male, 9 [64%] female) had nontuberculous mycobacteria facial skin lesions. Six (43%) had lesions on the cheek and five (36%) in the medial eye corner. Polymerase chain reaction results confirmed the presence of Mycobacterium haemophilum in eight patients (57%) and Mycobacterium avium in six patients (43%). The facial lesions were treated using a combination of clarithromycin and rifabutin for 12 weeks, with a median healing time of 4 months.
CONCLUSION
Nontuberculous mycobacteria facial lesions are rare in immunocompetent children. The diagnosis requires a high index of suspicion. Nonsurgical treatment is preferable, because surgical excision of the cutaneous lesions might lead to undesirable visible facial scars.
Topics: Adolescent; Child; Child, Preschool; Clarithromycin; Drug Combinations; Facial Dermatoses; Female; Humans; Infant; Male; Mycobacterium Infections, Nontuberculous; Mycobacterium avium; Mycobacterium haemophilum; Polymerase Chain Reaction; Rifabutin
PubMed: 26823205
DOI: 10.1111/pde.12755