-
International Journal of STD & AIDS Mar 2015Mycobacterium haemophilum is an environmental organism that rarely causes infections in humans. We report a patient with acquired immunodeficiency syndrome who had...
Mycobacterium haemophilum is an environmental organism that rarely causes infections in humans. We report a patient with acquired immunodeficiency syndrome who had central nervous system infection due to M. haemophilum. The diagnosis required brain tissue procurement and molecular identification method while the treatment outcome was unfavourable.
Topics: AIDS-Related Opportunistic Infections; Acquired Immunodeficiency Syndrome; Adult; Anti-Bacterial Agents; Biopsy; Central Nervous System Infections; Fatal Outcome; Female; Humans; Molecular Sequence Data; Mycobacterium Infections, Nontuberculous; Mycobacterium haemophilum; RNA, Bacterial; RNA, Ribosomal, 16S; Thailand
PubMed: 24841195
DOI: 10.1177/0956462414535750 -
BMJ Case Reports Nov 2019is a rare pathogen, predominately present in the immunocompromised population. It is especially studied in HIV and haematological malignancy patients. Given its unique...
is a rare pathogen, predominately present in the immunocompromised population. It is especially studied in HIV and haematological malignancy patients. Given its unique living conditions, it is often difficult to establish its diagnosis, but it is often suspected by its classic association with ulcerating skin findings. Our case is unique in that our patient is immunocompromised by his rheumatoid arthritis treatment, and presented without any skin lesions, but was found to have this rare pathogen causing a constellation of unusual symptoms.
Topics: Adalimumab; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Diagnosis, Differential; Humans; Immunocompromised Host; Lymph Nodes; Male; Mediastinal Diseases; Mycobacterium Infections; Mycobacterium haemophilum
PubMed: 31753822
DOI: 10.1136/bcr-2019-230871 -
Journal of Clinical Microbiology Jan 2018
Topics: Aged; Anti-Bacterial Agents; Exanthema; Fatal Outcome; Female; Humans; Kidney Transplantation; Mycobacterium Infections; Mycobacterium haemophilum; Thailand; Transplant Recipients
PubMed: 29279349
DOI: 10.1128/JCM.00561-17 -
Journal of Clinical Neuroscience :... Jun 2015We report a rare case of Mycobacterium haemophilum presenting as an intraventricular granulomatous mass with loculated hydrocephalus and seizures in a patient with human...
Intraventricular granulomatous mass associated with Mycobacterium haemophilum: A rare central nervous system manifestation in a patient with human immunodeficiency virus infection.
We report a rare case of Mycobacterium haemophilum presenting as an intraventricular granulomatous mass with loculated hydrocephalus and seizures in a patient with human immunodeficiency virus. M. haemophilum, a slow-growing mycobacteria, causes localized and disseminated disease among immunocompromised hosts. Central nervous system infection with M. haemophilum is extremely rare. Preoperative laboratory testing of our patient for tuberculosis, toxoplasmosis, sarcoidosis and histoplasmosis were negative. Surgical resection of the mass revealed a caseating granuloma that stained positive for acid-fast bacillus suggesting possible tuberculoma. Despite negative testing for tuberculosis, a polymerase chain reaction analysis was ultimately performed from the resected mass which revealed M. haemophilum. To our knowledge, this is the first case of M. haemophilum presenting as an intraventricular mass. We review the clinical manifestations of this pathogen and discuss the medical and surgical management.
Topics: Brain Diseases; Central Nervous System Infections; Cerebral Ventricles; Granuloma; HIV Infections; Humans; Immunocompromised Host; Male; Mycobacterium Infections; Mycobacterium haemophilum
PubMed: 25818941
DOI: 10.1016/j.jocn.2014.11.036 -
Dermatology Reports May 2015Non-tuberculous mycobacteria (NTM) are a group of environmental pathogens, which cause a broad spectrum of disease. The incidence of NTM infection is increasing,...
Non-tuberculous mycobacteria (NTM) are a group of environmental pathogens, which cause a broad spectrum of disease. The incidence of NTM infection is increasing, especially in immunocompromized patients. The past three decades also saw a rapid increase in the incidence of NTM infection involving otherwise healthy subjects. We report a case of cutaneous NTM infection in a 79-year-old Chinese woman, who was receiving methotrexate for psoriasis. Mycobacterial culture grew Mycobacterium abscessus, and the lesions cleared with a combination of oral clarithromycin, ciprofloxacin and doxycycline. Interestingly, she then developed a second episode of cutaneous NTM infection with Mycobacterium haemophilum over the same body region, five years after stoppage of methotrexate. Both episodes were separated in time and involved different species, indicating that they were independent from each other. We further discuss the risk factors for cutaneous NTM infection, treatment, and highlight the need for diagnostic vigilance.
PubMed: 26236445
DOI: 10.4081/dr.2015.5712 -
Cutis Sep 2019
Topics: Anti-Bacterial Agents; Humans; Immunocompromised Host; Leukemia, Myeloid, Acute; Male; Middle Aged; Mycobacterium Infections; Mycobacterium haemophilum; Skin Diseases, Bacterial; Stem Cell Transplantation
PubMed: 31675403
DOI: No ID Found -
The Journal of Dermatology Sep 2019
Topics: Adult; Biopsy; Diagnosis, Differential; Female; Graft Rejection; Humans; Immunocompromised Host; Immunosuppression Therapy; Kidney Transplantation; Mycobacterium Infections; Mycobacterium haemophilum; Skin; Skin Diseases, Bacterial; Sweet Syndrome
PubMed: 30938462
DOI: 10.1111/1346-8138.14864 -
Nederlands Tijdschrift Voor Geneeskunde 2017The differential diagnosis in a child with a swelling in the neck is broad. Chronic lymphadenopathy in children quite often leads to extensive blood tests. Cervicofacial...
BACKGROUND
The differential diagnosis in a child with a swelling in the neck is broad. Chronic lymphadenopathy in children quite often leads to extensive blood tests. Cervicofacial non-tuberculous mycobacterial (NTM) lymphadenitis is, however, not revealed by blood tests. It is a rare condition, which is mostly seen in young children.
CASE DESCRIPTION
A 4-year-old girl had a 9-week history of a swelling in her neck; the skin covering the swelling had been red and flaking for the past week. Extensive blood tests did not provide a firm diagnosis and ultrasound revealed 3 heterogeneous abscessing lymph glands with fistulas to the subcutaneous layer, leading to a probable diagnosis of cervicofacial NTM lymphadenitis. The infected lymph node package was excised, and microbiological culture was positive for Mycobacterium haemophilum.
CONCLUSION
NTM infections in young children are persistent infections that should be treated surgically at an early stage for the best cosmetic and functional result.
Topics: Child, Preschool; Female; Humans; Lymphadenitis; Mycobacterium Infections; Mycobacterium Infections, Nontuberculous; Mycobacterium haemophilum; Neck; Nontuberculous Mycobacteria
PubMed: 29076443
DOI: No ID Found -
Transplant Infectious Disease : An... Feb 2017Nontuberculous mycobacterial infections can often occur in individuals with adequate immune function. Such infections typically have cutaneous involvement and are caused...
Nontuberculous mycobacterial infections can often occur in individuals with adequate immune function. Such infections typically have cutaneous involvement and are caused by rapidly growing mycobacterium. Other nontuberculous mycobacteria species, like Mycobacterium haemophilum, almost always present as opportunistic infections occurring in severely immunocompromised hosts. Here, we present a complicated and protracted course of diagnosing M. haemophilum lower extremity cutaneous infection in a matched-unrelated donor stem cell transplant recipient.
Topics: Anti-Bacterial Agents; Biopsy; Cellulitis; Ciprofloxacin; Clarithromycin; Female; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Immunocompromised Host; Immunosuppression Therapy; Immunosuppressive Agents; Leukemia, Myeloid, Acute; Lower Extremity; Middle Aged; Mycobacterium Infections, Nontuberculous; Mycobacterium haemophilum; Opportunistic Infections; Rifabutin; Tacrolimus; Unrelated Donors
PubMed: 27775824
DOI: 10.1111/tid.12627 -
Journal of Infection in Developing... Mar 2015We report the first case of an immunocompromised adult patient presenting with cervicofacial lymphadenitis due to Mycobacterium haemophilum, confirmed using hsp65 gene...
We report the first case of an immunocompromised adult patient presenting with cervicofacial lymphadenitis due to Mycobacterium haemophilum, confirmed using hsp65 gene sequencing and line-probe assays. In resource-limited settings, especially in developing countries, appropriate culture methods and rapid molecular diagnostic tools such as hsp65 gene sequencing for identification of this organism may not be readily available. This may cause M. haemophilum infections to go unrecognised or lead to delays in diagnosis. Lack of heightened awareness about the potential for this mycobacterial species to cause infections may also contribute to possible underestimation of M. haemophilum cases in the developing world.
Topics: Adult; Bacterial Proteins; Chaperonin 60; DNA, Bacterial; Face; Female; Humans; Immunocompromised Host; Lymphadenitis; Molecular Diagnostic Techniques; Mycobacterium Infections; Mycobacterium haemophilum; Neck
PubMed: 25771471
DOI: 10.3855/jidc.5208