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Chinese Medical Journal Sep 2021
Topics: Castleman Disease; Fluorodeoxyglucose F18; Humans; Myopericytoma; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Radiopharmaceuticals
PubMed: 34561326
DOI: 10.1097/CM9.0000000000001626 -
Journal of Microscopy and Ultrastructure 2024Although myopericytoma and glomangiopericytoma are considered the subtypes of the group myopericytomas (MPC), they differ morphologically. Both of the tumors arise from...
Although myopericytoma and glomangiopericytoma are considered the subtypes of the group myopericytomas (MPC), they differ morphologically. Both of the tumors arise from pericytic cells. Scalp MPC are infrequent, but extranasal glomangiopericytomas are extremely rare. Herein, we report a case of a 36-year-old female presenting with slowly growing scalp swelling. Histopathology showed a dermal tumor with features of myopericytoma as well as glomangiopericytoma within the same lesion. Immunohistochemistry and reticulin staining confirmed pericytic origin but could not differentiate between the two tumors. This case report adds to the rarity and morphologic heterogeneity of the group MPC.
PubMed: 38633573
DOI: 10.4103/jmau.jmau_7_21 -
Thoracic Cancer Sep 2022Myopericytoma is a rare tumor generally arising from skin and soft tissues of extremities, trunk, head, and neck regions, rarely from visceral sites. An intrathoracic...
Myopericytoma is a rare tumor generally arising from skin and soft tissues of extremities, trunk, head, and neck regions, rarely from visceral sites. An intrathoracic visceral localization may carry a broad differential diagnosis including primary lung, pleura and chest wall lesions, or metastatic lesions. To date, any radiological features have been recognized and diagnosis of myopericytoma with intrathoracic localization remains still challenging. Here, we describe the case of a subpleural lesion incidentally diagnosed in an older adult affected by gastric cancer. Radiological features did not allow a differential diagnosis between a benign lesion, a primary tumor, or a metastasis. After resection, the histological examination showed histopathological features congruent with the diagnosis of myopericytoma. This unusual presentation reflects the need to share clinical, radiological, and histopathological data about this uncommon but frequently misdiagnosed disease.
Topics: Aged; Diagnosis, Differential; Humans; Myopericytoma; Thoracic Wall
PubMed: 35894765
DOI: 10.1111/1759-7714.14535 -
The American Journal of Surgical... Feb 2024Storiform collagenoma is a rare mesenchymal skin tumor that is composed of thickened collagen bundles arranged in a characteristic storiform pattern with a relatively...
Storiform collagenoma is a rare mesenchymal skin tumor that is composed of thickened collagen bundles arranged in a characteristic storiform pattern with a relatively hypocellular CD34-positive spindle cell component. Storiform collagenoma is most often sporadic, but multiple lesions can occur in Cowden syndrome, which is characterized by germline alterations in PTEN (phosphatase and tensin homolog) on chromosome 10. Here, we investigated the molecular pathogenesis of storiform collagenoma using a targeted next-generation DNA sequencing platform, including 5 sporadic cases and one case associated with Cowden syndrome. Recurrent PTEN alterations were identified in all cases, with biallelic PTEN inactivation observed in the case associated with Cowden syndrome and one sporadic case. Unexpectedly, we also identified recurrent activating mutations in the platelet-derived growth factor receptor beta ( PDGFRB ) gene. This included a missense substitution in the D5 Ig-like domain of PDGFRB in the Cowden syndrome-associated case. In addition, we report missense alterations in the juxtamembrane domain of PDGFRB in 4 of 5 (80%) sporadic cases, including mutations that have been previously described in sporadic myofibroma and myopericytoma. Therefore, we confirm the neoplastic nature of storiform collagenoma, we expand the spectrum of reported PDGFRB alterations in mesenchymal tumors and we suggest a possible collaborative role for PTEN and PDGFRB in the pathogenesis of storiform collagenoma.
Topics: Humans; Hamartoma Syndrome, Multiple; Receptor, Platelet-Derived Growth Factor beta; Fibroma; Skin Neoplasms; PTEN Phosphohydrolase; Mutation
PubMed: 37899509
DOI: 10.1097/PAS.0000000000002146 -
Child's Nervous System : ChNS :... Mar 2022Myopericytomas are benign soft tissue tumors which are rarely found as intracranial masses. (Review)
Review
BACKGROUND
Myopericytomas are benign soft tissue tumors which are rarely found as intracranial masses.
METHODS
A review of SCOPUS and PubMed databases for case reports and case series was done for patients with intracranial myopericytomas. Data on demographics, clinical features, imaging, surgical management employed, and outcomes were collected.
RESULTS
We found a total of 9 cases in the literature and we describe an additional case from our own experience. The mean age at presentation was 50.1 years (32-64 years), with a female predominance. Most tumors were in the posterior fossa and were multifocal in AIDS patients. The most common clinical manifestations were visual disturbances, headaches, and vomiting. An association with EBV was reported in two cases and was also found in our own case. Gross total excision and even subtotal excision were definitive therapies with no recurrences reported with a mean follow-up of 22.7 months. Our case is the first EBV-associated intracranial myopericytoma in a child.
CONCLUSION
Intracranial myopericytomas are rare; some have an association with EBV and immunodeficient states. Surgery is the only necessary treatment and outcomes are generally favorable for these benign neoplasms.
Topics: Brain Neoplasms; Child; Epstein-Barr Virus Infections; Female; Herpesvirus 4, Human; Humans; Male; Myopericytoma; Soft Tissue Neoplasms
PubMed: 34104988
DOI: 10.1007/s00381-021-05220-w -
British Journal of Neurosurgery Feb 2015Myopericytoma is a soft tissue tumour believed to be derived from perivascular myoid cells. They are typically found in subcutaneous tissues in the extremities....
Myopericytoma is a soft tissue tumour believed to be derived from perivascular myoid cells. They are typically found in subcutaneous tissues in the extremities. Intracranial myopericytomas are exceptionally rare. Here we report a man with an asymptomatic posterior fossa myopericytoma with evidence of dural infiltration.
PubMed: 25177778
DOI: 10.3109/02688697.2014.952270 -
The Journal of Craniofacial Surgery Jun 2017Myopericytoma is a slow-growing, benign soft tissue neoplasm that arises from perivascular smooth muscle cells. This tumor is a rare entity itself, but it is only...
Myopericytoma is a slow-growing, benign soft tissue neoplasm that arises from perivascular smooth muscle cells. This tumor is a rare entity itself, but it is only scarcely mentioned in the literature occurring secondary to trauma. The authors report a 21-year-old male patient who presented with a pulsatile mass in the medial canthal area where he had experienced previous trauma from a car accident 1-year prior. The mass was excised and histopathology revealed myopericytoma. This clinical report adds to the limited body of evidence supporting trauma as an etiology for this rare tumor.
Topics: Facial Injuries; Facial Neoplasms; Hemangiopericytoma; Humans; Male; Soft Tissue Neoplasms; Young Adult
PubMed: 28549043
DOI: 10.1097/SCS.0000000000003573 -
IJU Case Reports May 2023Myopericytomas usually occur in the extremities of older individuals; however, they also rarely occur in the penis. We report a case of myopericytoma in the corpus...
INTRODUCTION
Myopericytomas usually occur in the extremities of older individuals; however, they also rarely occur in the penis. We report a case of myopericytoma in the corpus cavernosum of the penis and review the relevant literature.
CASE PRESENTATION
A 76-year-old man presented with a slow-growing painless nodule on the left side of the penis. On physical examination, a non-tender, 7-mm mass was palpable. This tumor showed inhomogeneous low signal intensity on T2-weighted magnetic resonance imaging. The mass was excised and a myopericytoma diagnosed by pathological examination of the operative specimen.
CONCLUSION
We here report a rare case of myopericytoma in the corpus cavernosum of the penis. To the best of our knowledge, this is the second reported case of a myopericytoma in the penis and the first in the corpus cavernosum of the penis. Clinicians should keep this rare possibility in mind when investigating a mass in the penis.
PubMed: 37144080
DOI: 10.1002/iju5.12583 -
The British Journal of Oral &... Nov 2019We describe the case of a 46-year-old man who presented with a four-month history of a reddish, otherwise asymptomatic, nodular lesion that involved the mucosal side of...
We describe the case of a 46-year-old man who presented with a four-month history of a reddish, otherwise asymptomatic, nodular lesion that involved the mucosal side of the upper lip. The lesion consisted of myoid glomus-like cells arranged around branching and thin-walled haemangiopericytoma-like vascular structures, and was classified as glomangiopericytoma. No recurrences occurred during an eight-month follow-up. To the best of our knowledge, this tumour has never previously been described in the mucosa of the lip.
Topics: Diagnosis, Differential; Glomus Tumor; Hemangiopericytoma; Humans; Lip Neoplasms; Male; Middle Aged; Myopericytoma; Neoplasm Recurrence, Local
PubMed: 31285072
DOI: 10.1016/j.bjoms.2019.06.022 -
The Korean Journal of Thoracic and... Jun 2018Myopericytoma is a benign tumor that occurs in soft tissues. Myopericytoma in the lungs is very rare. We report the case of a 63-year-old woman presenting with cavitary...
Myopericytoma is a benign tumor that occurs in soft tissues. Myopericytoma in the lungs is very rare. We report the case of a 63-year-old woman presenting with cavitary masses in the left lung and multiple tiny nodules in both lungs. She underwent surgery, and a histological examination revealed primary pulmonary myopericytoma.
PubMed: 29854670
DOI: 10.5090/kjtcs.2018.51.3.220