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Anatolian Journal of Cardiology Feb 2023
Topics: Humans; Heart Neoplasms; Myxoma
PubMed: 36747450
DOI: 10.14744/AnatolJCardiol.2022.2599 -
Journal of Bronchology & Interventional... Oct 2018A 31-year-old woman presented with progressive breathlessness since 1 year. Flexible bronchoscopy revealed a vascular tumor completely occluding the right main bronchus....
A 31-year-old woman presented with progressive breathlessness since 1 year. Flexible bronchoscopy revealed a vascular tumor completely occluding the right main bronchus. A diagnosis of primary endobronchial myxoma was made. Tumor debulking was performed using rigid bronchoscopy. This enabled right lower lobectomy. A literature search yielded 12 cases of primary pulmonary myxoma, and only 2 previous reports of endobronchial myxoma. Most tumors were incidentally detected and were cured surgically. Endobronchial myxomas are rare and are usually asymptomatic. Treatment involves surgical excision. Rigid bronchoscopy serves as a bridge to surgery and can reduce the extent of surgery.
Topics: Adult; Airway Obstruction; Bronchi; Bronchial Neoplasms; Bronchoscopy; Female; Humans; Lung Diseases, Obstructive; Myxoma; Tomography, X-Ray Computed; Treatment Outcome; Vascular Neoplasms
PubMed: 30048419
DOI: 10.1097/LBR.0000000000000503 -
Anatolian Journal of Cardiology Aug 2023
Topics: Humans; Heart Neoplasms; Myxoma
PubMed: 37466027
DOI: 10.14744/AnatolJCardiol.2023.3240 -
European Journal of Ophthalmology Sep 2023The purpose of this study was to report the clinicopathological features and management of the first case of bilateral synchronous conjunctival myxoma. (Review)
Review
PURPOSE
The purpose of this study was to report the clinicopathological features and management of the first case of bilateral synchronous conjunctival myxoma.
METHODS
This study was a case report and literature review.
RESULTS
A 66-year-old Chinese male with past ocular history of uncomplicated bilateral phacoemulsification and intraocular lens (IOLs) 3 years ago prior to presentation presented with bilateral red and swollen conjunctiva for over a year. On examination his corrected distance visual acuity (CDVA) was 25/20 in the right eye 20/20 in the left eye. Slit lamp examination revealed swollen temporal conjunctiva bilaterally which appeared as painless, well-circumscribed, salmon-pink, fleshy patches. The lesion in the right eye was subsequently excised, followed by excision of the lesion in the left eye at 3-week interval. Microscopically, histopathological examination of both excised specimens revealed hypocellular conjunctival mucosa covered by non-dysplastic epithelium, with presence of myxoid degeneration in the subepithelial stroma and immunostaining findings consistent with conjunctival myxoma. At his latest follow-up at 24 months, there were no recurrences of the conjunctival masses and the CDVA was the same as preoperatively.
Topics: Male; Humans; Aged; Conjunctival Neoplasms; Conjunctiva; Myxoma; Slit Lamp Microscopy; Visual Acuity
PubMed: 36083167
DOI: 10.1177/11206721221124665 -
Journal of Cardiac Surgery Jul 2015Carney complex is a rare, autosomal dominant genetic disorder that consists of multiple myxomatous lesions and endocrine abnormalities, including skin lesions, cardiac... (Review)
Review
Carney complex is a rare, autosomal dominant genetic disorder that consists of multiple myxomatous lesions and endocrine abnormalities, including skin lesions, cardiac myxomas, primary pigmented nodular adrenocortical disease, and acromegaly. This review discusses the medical and surgical treatment of patients with Carney complex.
Topics: Adult; Age Factors; Cardiac Surgical Procedures; Carney Complex; Cause of Death; Chromosomes, Human, Pair 17; Chromosomes, Human, Pair 2; Cyclic AMP-Dependent Protein Kinase RIalpha Subunit; Echocardiography; Female; Genetic Counseling; Genetic Testing; Heart Neoplasms; Humans; Male; Mutation; Myxoma; Risk; Young Adult
PubMed: 25996461
DOI: 10.1111/jocs.12575 -
The Journal of Heart Valve Disease Nov 2017Cardiac myxomas are the most common primary tumors of the heart. Although these tumors have been reported in all cardiac chambers, myxomas arising from heart valves are... (Review)
Review
Cardiac myxomas are the most common primary tumors of the heart. Although these tumors have been reported in all cardiac chambers, myxomas arising from heart valves are extremely rare. Here, the details are described of a patient with mitral valve myxoma, and a review is provided of 99 cases reported in the literature. Mitral valve myxomas most often occur in middle-aged patients, with a slight female predominance. Most of the tumors arise in an isolated fashion on the atrial side of the anterior mitral valve leaflet. Embolic events were the most frequent manifestation, followed by obstructive symptoms. Unlike atrial wall myxomas, these tumors have a lower incidence of constitutional manifestations. Tumor resection with valve preservation is the usual method of surgical treatment in isolated tumors, while most patients with multiple valve myxomas underwent valve replacement. Mitral valve myxomas should be considered in the differential diagnosis of mitral valve tumors, with an awareness of a relatively high risk of embolic events. This location should not raise suspicion for a heritable myxoma syndrome. Prompt surgical resection is warranted to reduce complications.
Topics: Aged; Embolism; Female; Heart Neoplasms; Humans; Mitral Valve; Mitral Valve Stenosis; Myxoma; Syncope
PubMed: 30207120
DOI: No ID Found -
Dento Maxillo Facial Radiology Feb 2018Therapeutic assessment of odontogenic myxoma (OM) is poorly standardized. Unidimensional size criteria have shown to be unreliable in therapeutic decision-making. We... (Review)
Review
OBJECTIVES
Therapeutic assessment of odontogenic myxoma (OM) is poorly standardized. Unidimensional size criteria have shown to be unreliable in therapeutic decision-making. We evaluate the size distribution of OM and scan for associated clinicoradiological signs of aggressiveness. Additionally, we evaluate three-dimensional size delineation of OM aiming to improve future therapeutic assessment of this destructive neoplasm.
METHODS
Primarily, we reviewed the database "PubMed" for data concerning the size of OMs as radiologically determined. Afterwards, the impact of age, sex, locularity and location on the size was investigated by χ² test, Student's t-test and regression analysis. Furthermore, we statistically evaluated the impact of size on the occurrence of clinicoradiological signs of aggressiveness. Secondly, we approximated the volume of five unpublished cases of OM by semi-automatic image segmentation of cone-beam CT images.
RESULTS
Multilocular OMs were significantly larger than unilocular ones (p < 0.002). Age (0.042) and multilocularity (<0.002) significantly impacted size. Size was significantly associated with cortical perforation (0.032) and multilocularity (<0.002), further regression analysis revealed tooth resorption (0.019), cortical perforation (0.005) and multilocularity (<0.002) as significant predictors of size. Employing the volume as a mean of comparison, we found that the biggest OM (38.42 ml; multilocular) was 124 times larger than the smallest (0.31 ml; unilocular). However, using the maximum diameter (cm) as a surrogate for size, the biggest lesion (6.3) was only 5.25 times larger than the smallest (1.2).
CONCLUSIONS
Locularity and volumetric size characterization might help in therapeutic decision-making and could help to improve our understanding of OM.
Topics: Cone-Beam Computed Tomography; Humans; Imaging, Three-Dimensional; Myxoma; Odontogenic Tumors; Tumor Burden
PubMed: 29082773
DOI: 10.1259/dmfr.20170262 -
Advances in Experimental Medicine and... 2020Cardiac tumors are found in less than 1% of adult and pediatric autopsies. More than three-fourths of primary cardiac neoplasms are benign, with myxomas and rhabdomyomas... (Review)
Review
Cardiac tumors are found in less than 1% of adult and pediatric autopsies. More than three-fourths of primary cardiac neoplasms are benign, with myxomas and rhabdomyomas being the most common cardiac tumors seen in adults and children, respectively. Primary malignant cardiac tumors are extremely rare, whereas metastatic lesions can be seen in approximately 8% of patients dying from cancer. Attempting to understand why the heart is so resistant to carcinogenesis and which fail-safe mechanisms malfunction when cardiac tumors do develop is particularly challenging considering the rarity of these tumors and the fact that when relevant clinical studies are published, they rarely focus on molecular pathogenesis. Apart from cancer cells, solid tumors are comprised of a concoction of noncancerous cells, and extracellular matrix constituents, which along with pH and oxygen levels jointly constitute the so-called tumor microenvironment (TME). In the present chapter, we explore mechanisms through which TME may influence cardiac carcinogenesis.
Topics: Carcinogenesis; Heart Neoplasms; Humans; Myxoma; Rhabdomyoma; Tumor Microenvironment
PubMed: 32030675
DOI: 10.1007/978-3-030-36214-0_4 -
Journal of Cardiovascular Computed... 2017Although the primary role of Cardiac Computed Tomography (CCT) is assessment of the coronary arteries, the technique also allows detailed examination of cardiac...
BACKGROUND
Although the primary role of Cardiac Computed Tomography (CCT) is assessment of the coronary arteries, the technique also allows detailed examination of cardiac structures and other cardiac pathologies including cardiac myxoma. However, limited data exists regarding the CCT characteristics of cardiac myxoma.
OBJECTIVE
To describe the radiological characteristics of a series of cardiac myxomas in CCT.
METHODS
We retrospectively identified all patients at our tertiary urban referral centre with cardiac myxoma on CCT over a seven-year period between July 2008 and July 2015. We describe the CCT characteristics of eight cases. Seven of them had histologically documented myxoma after surgical removal, while one patient had a lesion suggestive of myxoma on echocardiography and CCT.
RESULTS
Eight patients were diagnosed with cardiac myxoma, comprising five females and three males. Seven of eight myxomas were located in the left atrium and one in the right atrium. Seven myxomas were polypoid in shape and one myxoma was villous. The average size was 22 × 26 mm. Calcification was present in half of the myxomas and average attenuation was 74 ± 46 Hounsfield Units.
CONCLUSION
CCT has an important role in assessment of cardiac structures. This series highlights the radiological characteristics of cardiac myxoma.
Topics: Aged; Aged, 80 and over; Calcinosis; Echocardiography; Female; Heart Atria; Heart Neoplasms; Humans; Male; Middle Aged; Myxoma; Predictive Value of Tests; Retrospective Studies; Tertiary Care Centers; Tomography, X-Ray Computed; Tumor Burden; Victoria
PubMed: 28202247
DOI: 10.1016/j.jcct.2017.02.002 -
The Pan African Medical Journal 2020Left ventricular (LV) myxomas are rare. We present a case of a LV myxoma arising from the interventricular septum in a 70-year-old asymptomatique man. General...
Left ventricular (LV) myxomas are rare. We present a case of a LV myxoma arising from the interventricular septum in a 70-year-old asymptomatique man. General examination of the patient did not reveal any abnormality. Transthoracic echocardiography revealed a round pedunculated mass (size, 20mm x 13mm) at the interventricular septum with a broad pedicle. The mass was successfully removed and was pathologically confirmed to be a myxoma.
Topics: Aged; Echocardiography; Heart Neoplasms; Heart Ventricles; Humans; Male; Myxoma
PubMed: 33224424
DOI: 10.11604/pamj.2020.36.358.24793