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Dermatologic Clinics Apr 2016Acne vulgaris (AV) is considered a straightforward diagnosis made clinically without specific diagnostic testing. However, certain disorders may simulate AV, such as... (Review)
Review
Acne vulgaris (AV) is considered a straightforward diagnosis made clinically without specific diagnostic testing. However, certain disorders may simulate AV, such as multiple small epidermal cysts or deep milia, multiple osteoma cutis, multiple small adnexal neoplasms, and follicular and/or infections characterized by multiple small papules and/or pustules such as gram-positive folliculitis, gram-negative folliculitis, Malassezia folliculitis, keratosis pilaris, and flat warts. This can lead to an erroneous diagnosis and improper management. Acneiform eruptions, often associated with ingestion of certain drugs and chemicals, can confound the clinician regarding AV diagnosis. We present herein an interesting case that was originally misdiagnosed as AV.
Topics: Acne Vulgaris; Acneiform Eruptions; Dermatomycoses; Diagnosis, Differential; Folliculitis; Humans; Skin
PubMed: 27015783
DOI: 10.1016/j.det.2015.12.002 -
Der Hautarzt; Zeitschrift Fur... Feb 2022There are many different types of skin neoplasms in children and most are benign. Dermatologists should be able to differentiate between the various types of benign skin... (Review)
Review
There are many different types of skin neoplasms in children and most are benign. Dermatologists should be able to differentiate between the various types of benign skin neoplasms and be able to recommend optimal treatment to concerned patients. Surgical removal of benign skin neoplasms is often the only treatment option. The aim of this paper is to provide a general overview of epidermal lesions (e.g., inflammatory linear verrucous epidermal nevus [ILVEN], nevus sebaceous), tumors of the epidermal appendages (e.g. pilomatrixoma), cutaneous neoplasms (e.g. angiofibroma), fibromatoses (e.g., knuckle pads), tumors comprised of fat, muscle, or bone tissue (e.g., osteoma cutis, subungual exostosis), epidermal cysts and pseudocysts, and pathologic fibrosis reactions after dermal injury (keloid). Scientific data are scarce and only in the last decade has it been possible to perform histopathological examinations and genetic studies together with detailed phenotyping to gain new understanding of the pathogenetic mechanisms.
Topics: Child; Epidermal Cyst; Hair Diseases; Humans; Nevus; Nevus, Pigmented; Skin Neoplasms
PubMed: 35029698
DOI: 10.1007/s00105-021-04935-w -
Dermatology Online Journal Dec 2014Osteoma cutis is the aberrant development of bone within the skin. The bone formation may be de novo (primary) or result from an injury to the skin (secondary). Here we...
Osteoma cutis is the aberrant development of bone within the skin. The bone formation may be de novo (primary) or result from an injury to the skin (secondary). Here we present a healthy 53-year-old man with no known abnormalities in calcium or phosphate metabolism with plate-like osteoma cutis of the scalp. Plate- or plaque-like osteoma cutis was initially described as a congenital condition but has now been reported several times in the literature as an idiopathic process that occurs in adults. Treatment options are limited and are only required if the lesion is bothersome to the patient.
Topics: Bone Diseases, Metabolic; Humans; Male; Middle Aged; Ossification, Heterotopic; Skin Diseases, Genetic
PubMed: 25526332
DOI: No ID Found -
Frontiers of Hormone Research 2019Pseudohypoparathyroidism (PHP), pseudo-PHP, acrodysostosis, and progressive osseous heteroplasia are heterogeneous disorders characterized by physical findings,... (Review)
Review
Pseudohypoparathyroidism (PHP), pseudo-PHP, acrodysostosis, and progressive osseous heteroplasia are heterogeneous disorders characterized by physical findings, differently associated in each subtype, including short bones, short stature, a stocky build, ectopic ossifications (features associated with Albright's hereditary osteodystrophy), as well as laboratory abnormalities consistent with hormone resistance, such as hypocalcemia, hyperphosphatemia, and elevated parathyroid hormone (PTH) and thyroid-stimulating hormone levels. All these disorders are caused by impairments in the cAMP-mediated signal transduction pathway and, in particular, in the PTH/PTHrP signaling pathway: the main subtypes of PHP and related disorders are caused by de novo or autosomal dominantly inherited inactivating genetic mutations, and/or epigenetic, sporadic, or genetic-based alterations within or upstream of GNAS, PRKAR1A, PDE4D, and PDE3A. Here we will review the impressive progress that has been made over the past 30 years on the pathophysiology of these diseases and will describe the recently proposed novel nomenclature and classification. The new term "inactivating PTH/PTHrP signaling disorder," iPPSD: (1) defines the common mechanism responsible for all diseases, (2) does not require a confirmed genetic defect, (3) avoids ambiguous terms like "pseudo," and (4) eliminates the clinical or molecular overlap between diseases.
Topics: Bone Diseases, Metabolic; Dysostoses; Humans; Intellectual Disability; Ossification, Heterotopic; Osteochondrodysplasias; Parathyroid Hormone; Parathyroid Hormone-Related Protein; Pseudohypoparathyroidism; Signal Transduction; Skin Diseases, Genetic
PubMed: 30641531
DOI: 10.1159/000491045 -
JAAD Case Reports Apr 2022
PubMed: 35242977
DOI: 10.1016/j.jdcr.2022.01.023 -
European Journal of Dermatology : EJD Nov 2022
Topics: Humans; Bone Diseases, Metabolic; Skin Diseases, Genetic
PubMed: 36856402
DOI: 10.1684/ejd.2022.4386 -
European Journal of Dermatology : EJD Aug 2018Multiple miliary osteoma cutis consists of heterotopic foci of bone tissue in the dermis and subcutaneous tissue. Patients usually present with multiple, asymptomatic... (Review)
Review
Multiple miliary osteoma cutis consists of heterotopic foci of bone tissue in the dermis and subcutaneous tissue. Patients usually present with multiple, asymptomatic facial papules of several millimetres in diameter which cause distress regarding their cosmetic appearance. The condition is described as rare, as only a few cases have been reported since its first description in 1864 by Virchow. We therefore carried out a comprehensive literature search and review, in which 102 published cases were retrieved and analysed. The demographic and clinical aspects, as well as current therapy solutions, of this probably overlooked condition are discussed.
Topics: Bone Density Conservation Agents; Bone Diseases, Metabolic; Dermatologic Surgical Procedures; Diagnosis, Differential; Humans; Ossification, Heterotopic; Retinoids; Skin Diseases, Genetic
PubMed: 30325330
DOI: 10.1684/ejd.2018.3365 -
Journal of Paediatrics and Child Health Jul 2022
Topics: Bone Diseases, Metabolic; Humans; Ossification, Heterotopic; Skin Diseases, Genetic
PubMed: 34706128
DOI: 10.1111/jpc.15814