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Surgical Pathology Clinics Mar 2021Papillary lesions of the salivary duct systems are uncommon. They encompass a heterogeneous group of benign, intermediate, and potentially aggressive neoplasms. With a... (Review)
Review
Papillary lesions of the salivary duct systems are uncommon. They encompass a heterogeneous group of benign, intermediate, and potentially aggressive neoplasms. With a few exceptions, historical descriptive terms such as papillary adenocarcinoma, papillary cystadenocarcinoma, and papillary adenoma are being replaced by defined entities, at same time acknowledging the papillary features as a histologic pattern. The evolving genetic landscape of these lesions increasingly permits their reproducible categorization. This article discusses those papillary proliferations encountered in the salivary glands with a focus on intraductal papillary mucinous neoplasms and cystadenomas. Intraductal carcinomas and sialadenoma papilliferum are addressed in separate articles in this issue.
Topics: Adenocarcinoma, Papillary; Cell Proliferation; Diagnosis, Differential; Humans; Mutation; Prognosis; Proto-Oncogene Proteins c-akt; Salivary Gland Neoplasms
PubMed: 33526223
DOI: 10.1016/j.path.2020.09.007 -
Ear, Nose, & Throat Journal Dec 2017
Topics: Adenocarcinoma, Papillary; Humans; Nasopharyngeal Neoplasms
PubMed: 29236265
DOI: 10.1177/014556131709601203 -
The American Journal of Surgical... Oct 2023Recurrent oncogenic drivers have been identified in a variety of sweat gland tumors. Recently, integration of human papillomavirus type 42 (HPV42) has been reported in...
Recurrent oncogenic drivers have been identified in a variety of sweat gland tumors. Recently, integration of human papillomavirus type 42 (HPV42) has been reported in digital papillary adenocarcinoma (DPA). The main objectives of the present study were (i) to provide an overview of the prevalence of previously identified oncogenic drivers in acral sweat gland tumors and (ii) to genetically characterize tumors in which no recurrent genetic alteration has been identified yet. Cases of acral sweat gland tumors were identified from the database of the French network CARADERM. After histologic review, the presence of previously identified genetic alterations was investigated in the entire cohort (n=79) using a combination of immunohistochemistry and targeted DNA and RNA sequencing. Tumor entities with no recurrent genetic alterations were submitted to whole-transcriptome sequencing. CRTC1::MAML2 fusion was identified in cases of hidradenoma and hidradenocarcinoma (n=9/12 and n=9/12). A p.V600E mutation of BRAF was observed in all cases of tubular adenoma (n=4). YAP1:MAML2 and YAP1::NUTM1 fusions were observed in poroid tumors (n=15/25). ETV6::NTRK3 and TRPS1::PLAG1 fusion transcripts were identified in secretory carcinoma (n=1/1) and cutaneous mixed tumors (n=3/4), respectively. The HPV42 genome was detected in most cases of DPA (n=10/11) and in 1 adnexal adenocarcinoma not otherwise specified. Finally, whole-transcriptome analysis revealed BRD3::NUTM1 or NSD3::NUTM1 fusions in 2 cases of NUT adnexal carcinoma and NCOA4::RET and CCDC6::RET fusion transcripts in 2 cystadenoma/hidrocystoma-like tumors. Our study confirms distinctive cytogenetic abnormalities in a wide number of acral adnexal neoplasms and supports the use of molecular analysis as a valuable aid in the diagnosis of these rare and often difficult to diagnose group of neoplasms.
Topics: Humans; Sweat Gland Neoplasms; Skin Neoplasms; Carcinoma; Acrospiroma; Transcription Factors; Adenocarcinoma, Papillary; Repressor Proteins
PubMed: 37505808
DOI: 10.1097/PAS.0000000000002098 -
American Journal of Clinical Pathology Oct 2019Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TLLGNPPA) is a relatively rare nasopharyngeal tumor. We performed morphological characterization,... (Review)
Review
OBJECTIVES
Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TLLGNPPA) is a relatively rare nasopharyngeal tumor. We performed morphological characterization, immunohistochemical profiling, and investigated gene mutations. We also provide clinical follow-up data and brief review of the literature.
METHODS
Immunohistochemistry was used to evaluate the expression of TTF-1, CK19, CK7, EMA, TG, Pax-8, CK5/6, S100, and Ki-67. Additionally, in situ hybridization was utilized to identify the presence of EBV. We investigated mutations in hot-spot exons of KRAS/NRAS/BRAF to rule out common mutations seen in thyroid tumors.
RESULTS
Histopathologic examination of four cases identified tumors that were mainly occupied by papillary architectures. One case had a predominantly glandular structure. The tumors expressed TTF-1 and CK19, while TG and Pax-8 were negative. S100 was moderately expressed focally in three cases.
CONCLUSIONS
While TLLGNPPA displays a morphological resemblance to papillary thyroid carcinoma (PTC), it is vital to differentiate nasopharyngeal metastasis from PTC for appropriate treatment.
Topics: Adenocarcinoma, Papillary; Adult; Biomarkers, Tumor; DNA-Binding Proteins; Diagnosis, Differential; Female; Humans; Immunohistochemistry; Male; Mutation; Nasopharyngeal Neoplasms; S100 Proteins; Thyroid Cancer, Papillary; Tomography, X-Ray Computed; Transcription Factors
PubMed: 31287861
DOI: 10.1093/ajcp/aqz082 -
Journal of the College of Physicians... Nov 2019Low-grade nasopharyngeal papillary adenocarcinoma is a rare tumor, and only a limited number of cases are reported in the literature. The case reported in this study had...
Low-grade nasopharyngeal papillary adenocarcinoma is a rare tumor, and only a limited number of cases are reported in the literature. The case reported in this study had long-term nasal catarrh with a runny nose and was admitted to the hospital. Computed tomography (CT) examination revealed polypoid mass in the nasopharynx. Pathological examination revealed typical papillary growth pattern of glandular epithelial cells. Immunohistochemical (IHC) staining showed the tumor cells to be diffusely positive for cytokeratin 7 (CK7), vimentin, and thyroid transcription factor 1 (TTF-1). The Ki-67 proliferation index was approximately 1%. In situ hybridization for latent Ebstein-virus (EBV) injection was negative. The patient did not exhibit recurrence or metastasis of the tumor.
Topics: Adenocarcinoma, Papillary; Aged; Biomarkers, Tumor; Biopsy; Diagnosis, Differential; Female; Humans; Nasopharyngeal Neoplasms; Neoplasm Grading; Tomography, X-Ray Computed
PubMed: 31659975
DOI: 10.29271/jcpsp.2019.11.1114 -
Human Pathology Apr 2023Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TLLGNPPA) is a rare nasopharyngeal carcinoma. To date, less than 60 cases of TLLGNPPA have been reported,...
Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TLLGNPPA) is a rare nasopharyngeal carcinoma. To date, less than 60 cases of TLLGNPPA have been reported, and its clinical features and pathogenesis remain unclear. In this paper, four cases of TLLGNPPA were reported to clarify the clinicopathological and molecular features of this disease. Histopathological examination revealed that all tumors had papillary glandular arrangement, with a fibrovascular axis in the tumor stroma and focal nuclear groove. All tumors expressed pan-CK, CK7, and CK19, while TG and Pax-8 were negative, and the Ki-67 index was approximately 1-3%. The expression of TTF-1 was diffusely positive in two cases and focally positive in two cases. EBER was not expressed in four cases. Molecular testing was possible in three cases. No common driver event was noted, but unique, mutually exclusive molecular variants were found in each of the three tumors (FGFR4, PDK1, AXIN2, FOXL2, and PIK3C3), one also with copy number variants in MCL1 and STMN1. All four patients underwent surgical resection of the tumor and had no metastasis or recurrence from 7 to 60 months post-resection. Given the assertion that these tumors do not recur or metastasize in addition to their heterogeneous gene mutation spectrum, we propose that TLLGNPPA is a neoplasm with low malignant potential and should no longer to be referred to as an adenocarcinoma.
Topics: Humans; Thyroid Gland; Adenocarcinoma, Papillary; Nasopharyngeal Neoplasms; Immunohistochemistry; Nasopharyngeal Carcinoma
PubMed: 36549599
DOI: 10.1016/j.humpath.2022.12.009 -
Pathologica Mar 2019
Topics: Adenocarcinoma; Female; Humans; Thyroid Cancer, Papillary; beta Catenin
PubMed: 31217615
DOI: 10.32074/1591-951X-66-18 -
Annales de Pathologie Mar 2024
Topics: Humans; Thyroid Neoplasms; Carcinoma, Papillary, Follicular; Neoplasms, Glandular and Epithelial; Adenocarcinoma, Follicular
PubMed: 38388329
DOI: 10.1016/j.annpat.2024.01.016 -
Pathology Oct 2017The molecular alterations and pathological features of gastric papillary adenocarcinoma (GPA) remain unknown. We examined GPA samples and compared their molecular and...
The molecular alterations and pathological features of gastric papillary adenocarcinoma (GPA) remain unknown. We examined GPA samples and compared their molecular and pathological characteristics with those of gastric tubular adenocarcinoma (GTA). Additionally, we identified pathological and molecular features of GPA that vary with microsatellite stability. In the present study, samples from 63 GPA patients and 47 GTA patients were examined using a combination of polymerase chain reaction (PCR)-microsatellite assays and PCR-pyrosequencing in order to detect microsatellite instability (microsatellite instability, MSI; microsatellite stable, MSS), methylation status (low methylation, intermediate methylation and high methylation level), and chromosomal AI in multiple cancer-related loci. Additionally, the expression levels of TP53 and Her2 were evaluated using immunohistochemistry. GTA and GPA are statistically different in their frequency of pathological features, including mucinous, poorly differentiated and invasive micropapillary components. Clear genetic patterns differentiating GPA and GTA could not be identified with a hierarchical cluster analysis, but microsatellite stability was linked with TP53 and Her2 overexpression. Methylation status in GPA was also associated with the development of high microsatellite instability. However, no pathological differences were associated with microsatellite stability. We suggest that although molecular alterations in a subset of GPAs are closely associated with microsatellite stability, they play a minor role in GPA carcinogenesis.
Topics: Adenocarcinoma; Adenocarcinoma, Papillary; Adult; Aged; Aged, 80 and over; Allelic Imbalance; Cluster Analysis; DNA Methylation; Female; Humans; Immunohistochemistry; Male; Microsatellite Instability; Middle Aged; Phenotype; Receptor, ErbB-2; Stomach Neoplasms; Tumor Suppressor Protein p53
PubMed: 28830689
DOI: 10.1016/j.pathol.2017.07.004 -
Seminars in Pediatric Surgery Jun 2020An increasing number of children are diagnosed with differentiated thyroid cancer. With an excellent prognosis for the majority of pediatric patients, the goal of... (Review)
Review
An increasing number of children are diagnosed with differentiated thyroid cancer. With an excellent prognosis for the majority of pediatric patients, the goal of therapy is to optimize outcome while reducing complications. Increased knowledge of the somatic, oncogenic driver mutations provides opportunities to improve the accuracy of diagnosis, to stratify surgery, and to treat patients with morbidly invasive or refractory disease. Treatment complications can be reduced by referral to regional, high-volume pediatric thyroid centers.
Topics: Adenocarcinoma, Follicular; Adolescent; Child; Combined Modality Therapy; Genetic Predisposition to Disease; Humans; Iodine Radioisotopes; Radiopharmaceuticals; Thyroid Cancer, Papillary; Thyroid Neoplasms; Thyroidectomy
PubMed: 32571505
DOI: 10.1016/j.sempedsurg.2020.150920