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Head and Neck Pathology Sep 2017Sinonasal (Schneiderian) papillomas are benign neoplasms that arise in the sinonasal tract. Since their initial descriptions, sinonasal papillomas have triggered debate... (Review)
Review
Sinonasal (Schneiderian) papillomas are benign neoplasms that arise in the sinonasal tract. Since their initial descriptions, sinonasal papillomas have triggered debate regarding their classification, etiology, rate or predictors of malignant transformation, and other issues. While significant strides have been made in recent years, there are still aspects of sinonasal papillomas that remain unclear even now. This review will serve to update the practicing pathologist on the current understanding of sinonasal papillomas.
Topics: Humans; Nasal Mucosa; Papilloma; Paranasal Sinus Neoplasms
PubMed: 28321771
DOI: 10.1007/s12105-017-0799-9 -
Bulletin Du Cancer Jun 2018To report a series of 5 patients with urothelial bladder cancer (UBC) three of them with a history of exposure to amines and only two with gross hematuria. (Review)
Review
OBJECTIVE
To report a series of 5 patients with urothelial bladder cancer (UBC) three of them with a history of exposure to amines and only two with gross hematuria.
MATERIALS AND METHODS
After obtaining ethical and legal authorization, we performed a restrospective monocentric study. We collected information of patients with UBC over a period of 10 years. We recorded: age, sex, reason for presentation, familial history and risk factors, preoperative assessment, surgical details, histological type and grade, follow-up.
RESULTS
2 children came to our attention for hematuria and 3 for incidental bladder mass finding, at a median age of 11.8 years. We performed microscopically complete transurethral resection of the tumor (TURB). Median tumor size was 1.8cm. No further therapy was required. All cancers belonged to NMIBC (Non-muscle-invasive Bladder Cancer) considering the 2004 WHO classification: 2 urothelial papillomas, 2 papillary tumors with low grade malignancy (PUN-LPM) and 1 papillary urothelial carcinoma of low histological grade (LG-PUC Ta, N0, M0). There was not any complications and no relapse occurred during follow-up (median 30 months).
CONCLUSIONS
In this study, UBCs presenting at a young age were low-grade and have not recurred in follow-up. This confirms the results of other series reported in Literature. Therefore there might be the space to perform a follow-up dedicated to children.
Topics: Adolescent; Amines; Carcinoma, Papillary; Child; Female; Hematuria; Humans; Incidental Findings; Male; Papilloma; Retrospective Studies; Risk Factors; Tumor Burden; Urinary Bladder Neoplasms
PubMed: 29724585
DOI: 10.1016/j.bulcan.2018.03.002 -
Pediatric Dermatology Jan 2021Papillomatosis cutis lymphostatica is an uncommon condition usually associated with lymphedema. "Ski-jump" nails are upward sloping concave nails that can be an...
Papillomatosis cutis lymphostatica is an uncommon condition usually associated with lymphedema. "Ski-jump" nails are upward sloping concave nails that can be an important diagnostic sign which may be overlooked in the setting of lymphedema. A diagnosis of papillomatosis cutis lymphostatica should be suspected in patients presenting with persistent, bland papilliform plaques, supported by the additional presence of "ski-jump" nails.
Topics: Humans; Lymphedema; Nails; Nails, Malformed; Papilloma; Skin
PubMed: 33210394
DOI: 10.1111/pde.14457 -
Ophthalmic Plastic and Reconstructive...Conjunctival papillomas are common tumors that exhibit an exophytic growth pattern, comprised of multiple filiform fronds of squamous epithelium that contain...
Conjunctival papillomas are common tumors that exhibit an exophytic growth pattern, comprised of multiple filiform fronds of squamous epithelium that contain fibrovascular cores. The inverted (endophytic) variety of papilloma, often termed "Schneiderian," rarely occurs on the conjunctiva, with only 15 cases reported to date. Endophytic and exophytic papillomas are well described arising in the sinonasal Schneiderian epithelium where a low rate of malignant transformation may occur in the endophytic type; malignant transformation in exophytic sinonasal papillomas is exceedingly rare. The authors describe 2 cases of exophytic conjunctival papillomas with the morphology of a sinonasal or Schneiderian-type papilloma. Both were pink, sessile acquired growths in women in the sixth decade of life involving the inferior conjunctival fornix or nasal limbus. Nonkeratinizing squamous epithelium along with numerous goblet cells, intraepithelial mucinous cysts, and microabscesses were present. Immunohistochemistry showed reactivity for cytokeratin 7 and wild-type staining for p16 and p53, paralleling the findings in common conjunctival papillomas; both were also driven by low-risk human papillomavirus.
Topics: Cell Transformation, Neoplastic; Conjunctiva; Female; Humans; Immunohistochemistry; Nose Neoplasms; Papilloma
PubMed: 34284422
DOI: 10.1097/IOP.0000000000001983 -
Ophthalmology Feb 2023
Topics: Humans; Conjunctiva; Papilloma; Conjunctival Neoplasms
PubMed: 35803837
DOI: 10.1016/j.ophtha.2022.05.023 -
Mayo Clinic Proceedings Jun 2023
Topics: Humans; Larynx; Laryngeal Neoplasms; Bronchial Neoplasms; Papilloma
PubMed: 37270273
DOI: 10.1016/j.mayocp.2023.02.011 -
European Journal of Dermatology : EJD Feb 2018
Topics: Diagnosis, Differential; Female; Humans; Middle Aged; Nail Diseases; Papilloma; Thumb
PubMed: 29521635
DOI: 10.1684/ejd.2018.3241 -
Pediatric Dermatology Sep 2021Confluent and reticulated papillomatosis is a skin condition with unclear etiology and limited understanding of risk factors, comorbidities, and treatment strategies in...
BACKGROUND/OBJECTIVES
Confluent and reticulated papillomatosis is a skin condition with unclear etiology and limited understanding of risk factors, comorbidities, and treatment strategies in the pediatric population. This study aims to describe the varied presentations and outcomes of confluent and reticulated papillomatosis and report associated comorbidities in pediatric patients.
METHODS
In this retrospective single-institution case-control study, pediatric patients with a diagnosis of confluent and reticulated papillomatosis seen between 2012 and 2020 were matched approximately 1:5 with an acne vulgaris cohort based on diagnosis, setting, and time period when seen. The primary measures were the clinical features, demographics, comorbidities, treatment, and outcomes of patients with confluent and reticulated papillomatosis. Univariate and multivariable analyses were conducted to describe the association of confluent and reticulated papillomatosis with several potential risk factors and comorbidities.
RESULTS
Patients with confluent and reticulated papillomatosis typically presented in adolescence with a median age of 14 years and female predominance. In a multivariable analysis, patients with confluent and reticulated papillomatosis were significantly more likely to identify as Black, be overweight or obese, and have concurrent acanthosis nigricans compared to control patients. Most of the confluent and reticulated papillomatosis patients were treated with oral minocycline or doxycycline. Although all patients who received antibiotics responded to treatment, approximately half presented with recurrence, typically within 1-2 years of first treatment.
CONCLUSIONS
Confluent and reticulated papillomatosis is a disorder that presents in adolescence and appears to be more frequent in patients who are Black, obese, or overweight, and also have acanthosis nigricans. Clinicians should assess patients with confluent and reticulated papillomatosis for comorbidities, particularly those associated with insulin resistance, which may help reduce long-term disease burden.
Topics: Adolescent; Case-Control Studies; Child; Female; Humans; Neoplasm Recurrence, Local; Papilloma; Retrospective Studies; Skin Neoplasms
PubMed: 34561886
DOI: 10.1111/pde.14806 -
The Laryngoscope Jul 2024To characterize the distribution of immune cell subsets within laryngeal papillomas and to study the function of potentially immunosuppressive neutrophilic and...
OBJECTIVES
To characterize the distribution of immune cell subsets within laryngeal papillomas and to study the function of potentially immunosuppressive neutrophilic and regulatory T cells (Tregs).
METHODS
Fresh clinical papilloma specimens were collected at the time of surgery and studied with multiparameter flow cytometry. Papilloma infiltrating neutrophilic cells and Tregs were sorted and studied functionally with ex vivo T cell suppression assays.
RESULTS
Flow cytometric analysis of fresh laryngeal papillomas samples from 18 adult patients with recurrent respiratory papillomatosis revealed patterns in immune constituency between patients. Clearly divergent phenotypes based primarily on the degree of neutrophilic and T cell infiltration were identified. Relative neutrophilic cell enrichment and T cell depletion were observed in 50% of samples and neutrophilic cell depletion and T cell enrichment were observed in the others. Greater papilloma neutrophilic cell enrichment was positively associated with the number of clinically indicated interventions required in the 12 months prior to sample collection, linking papilloma neutrophil inflammation to disease severity. Functional assays revealed the ability of both papilloma infiltrating neutrophilic and Tregs to suppress T cell function at roughly equal magnitudes, but substantially increased infiltration of neutrophilic cells compared to Tregs across samples.
CONCLUSION
Neutrophilic cells are an important contributor to immunosuppression within the respiratory papilloma microenvironment. Given these data and the association between greater neutrophilic cell infiltration and lack of clinical response to therapeutic vaccination, additional study of strategies aimed at limiting neutrophilic cell infiltration or function within papillomas is warranted.
LEVEL OF EVIDENCE
4 Laryngoscope, 134:3238-3244, 2024.
Topics: Humans; Neutrophils; T-Lymphocytes, Regulatory; Flow Cytometry; Male; Adult; Phenotype; Papilloma; Female; Middle Aged; Papillomavirus Infections; Respiratory Tract Infections; Laryngeal Neoplasms; Tumor Microenvironment; Aged
PubMed: 38436434
DOI: 10.1002/lary.31375 -
The Breast Journal Sep 2020
Topics: Adenoma; Breast Neoplasms; Female; Humans; Nipples; Papilloma
PubMed: 32469099
DOI: 10.1111/tbj.13905